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Cyclonellin, a new cyclic octapeptide from the marine sponge Axinella carteri

  1. Author:
    Milanowski, D. J.
    Rashid, M. A.
    Gustafson, K. R.
    O'Keefe, B. R.
    Nawrocki, J. P.
    Pannell, L. K.
    Boyd, M. R.
  2. Author Address

    Gustafson, KR, Canc Res Ctr, Mol Targets Dev Program, NCI, Bldg 1052,Room 121, Frederick, MD 21702 USA Canc Res Ctr, Mol Targets Dev Program, NCI, Frederick, MD 21702 USA. SAIC, Intramural Res Support Program, Frederick, MD 21702 USA. NIDDKD, Bioorgan Chem Lab, Bethesda, MD 20892 USA. Univ S Alabama, Coll Med, USA Canc Res Inst, Mobile, AL 36688 USA.
    1. Year: 2004
  1. Journal: Journal of Natural Products
    1. 67
    2. 3
    3. Pages: 441-444
  2. Type of Article: Article
  1. Abstract:

    Cyclonellin (1), a new cyclic octapeptide, was isolated from an aqueous extract of the marine sponge Axinella carteri. Its structure was elucidated by interpretation of NMR spectral data of the intact compound and N-terminal Edman sequencing of linear peptide fragments obtained by partial hydrolysis of 1. The absolute configurations of the constituent amino acids were determined by acid hydrolysis, derivitization with FDAA, and LC-MS analyses

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