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Serum proteomic profiles suggest celecoxib-modulated targets and response predictors

  1. Author:
    Zhen, X. A.
    Luke, B. T.
    Izmirlian, G.
    Umar, A.
    Lynch, P. M.
    Phillips, R. K. S.
    Patterson, S.
    Conrads, T. P.
    Veenstra, T. D.
    Greenwald, P.
    Hawk, E. T.
    Ali, L. U.

  2. Author Address

    Ali, LU, NCI, Div Canc Prevent, Bethesda, MD 20893 USA NCI, Div Canc Prevent, Bethesda, MD 20893 USA. NCI, Lab Proteom & Analyt Technol, SAIC Frederick Inc, Frederick, MD 21701 USA. NCI, Adv Biomed Comp Ctr, SAIC Frederick Inc, Frederick, MD 21701 USA. Univ Texas, MD Anderson Canc Ctr, Houston, TX 77030 USA. St Marks Hosp, Imperial Canc Res Fund, London EC1V 2PS, England.
    1. Year: 2004
  2. Journal: Cancer Research
    1. 64
    2. 8
    3. Pages: 2904-2909
  4. Type of Article: Article
  1. Abstract:

    Cyclooxygenase-2 is a valid target for cancer prevention and treatment. This has been shown in preclinical and clinical cancer prevention studies by using a cyclooxygenase-2 inhibitor, celecoxib. When used in a randomized cancer prevention clinical trial on patients with the inherited autosomal dominant condition, familial adenomatous polyposis, celecoxib proved efficacious. However, a remarkable heterogeneity in patients' responses to the chemopreventive effects of celecoxib was observed. Proteomic profiling of sera from these patients identified several markers, the expression of which was specifically modulated after treatment with celecoxib. A decision tree algorithm identified classifiers for response to celecoxib with relatively high sensitivity but moderate to low specificity. In particular, a spectral feature at m/z 16,961.4 was identified as a strong discriminator between response and nonresponse to celecoxib at the highest dose

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