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Malignant Transformation of Mammalian Cells Initiated By Constitutive Expression of the Polo-Like Kinase

  1. Author:
    Smith, M. R.
    Wilson, M. L.
    Hamanaka, R.
    Chase, D.
    Kung, H. F.
    Longo, D. L.
    Ferris, D. K.

  2. Author Address

    Smith MR NCI FREDERICK CANC RES & DEV CTR INTRAMURAL RES SUPPORT PROGRAM SAIC FREDERICK FREDERICK, MD 21702 USA UNIV CALIF SAN DIEGO GRAD PROGRAM BIOMED SCI SAN DIEGO, CA 92093 USA OITA MED UNIV DEPT BIOCHEM OITA 8791706 JAPAN NCI FREDERICK CANC RES & DEV CTR NIA FREDERICK, MD 21702 USA NCI FREDERICK CANC RES & DEV CTR LAB BIOCHEM PHYSIOL DIV BASIC SCI FREDERICK, MD 21702 USA NIA NIH BALTIMORE, MD 21224 USA
    1. Year: 1997
  2. Journal: Biochemical and Biophysical Research Communications
    1. 234
    2. 2
    3. Pages: 397-405
  4. Type of Article: Article
  1. Abstract:

    Polo-like kinase (Plk) is the mammalian homologue of the Drosophila polo and Saccharomyces cerevisiae CDC5 genes, which are thought to be involved in regulating chromosomal segregation. Previously, we showed that transient ectopic expression of Plk could induce DNA synthesis in quiescent NIH 3T3 cells, suggesting that Plk might also have a function during G(1) or S phase, Here we report that microinjection of Plk mRNA is sufficient to drive quiescent cells into mitosis and that constitutive expression of Plk in NIH 3T3 cells causes oncogenic focus formation. These transformed cells grow in soft agar and form tumors in nude mice. Because Plk expression has been shown to be high in various human tumors, we suggest that Plk may contribute to the promotion and/or progression of human cancers. (C) 1997 Academic Press. [References: 39]

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