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A natural products chemist looks at the bystander effect!

  1. Author:
    Newman, D. J.

  2. Author Address

    NCI, Nat Prod Branch, Dev Therapeut Program, Frederick, MD 21702 USA Newman, DJ, NCI, Nat Prod Branch, Dev Therapeut Program, POB B, Frederick, MD 21702 USA
    1. Year: 2006
    2. Date: MAY 11
  2. Journal: Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis
    1. 597
    2. 1-2
    3. Pages: 39-42
  4. Type of Article: Article
  1. Abstract:

    The bystander effect is a process whereby the medium in which cells are irradiated at very low levels is presumed to contain a "low molecular weight" entity that will induce cell death and/or genetic changes in fresh mammalian cells when they are incubated in the medium. Following discussions at a recent meeting in McMaster University, suggestions are made in this paper as to the possibility for the "entity" to be nitric oxide and recommendations are given as to methods that will permit a systematic (bio)chemical search to be performed in order to identify the "activator" and prove/disprove the hypothesis. Published by Elsevier B.V

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.mrfmmm.2005.04.026
  3. View record in Web of Science®
  4. WOS: 000237710800006

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