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An armed-disarmed approach for blocking aglycon transfer of thioglycosides

  1. Author:
    Li, Z. T.
    Gildersleeve, J. C.
  2. Author Address

    NCI, Canc Res Ctr, Lab Med Chem, Frederick, MD 21702 USA.;Gildersleeve, JC, NCI, Canc Res Ctr, Lab Med Chem, Frederick, MD 21702 USA.;gildersleevej@ncificrf.gov
    1. Year: 2007
    2. Date: Jan
  1. Journal: Tetrahedron Letters
    1. 48
    2. 4
    3. Pages: 559-562
  2. Type of Article: Article
  3. ISSN: 0040-4039
  1. Abstract:

    Th ioglycosides are used frequently as glycosyl donors and as mimetics of O-glycosides. While being very useful, thioglycosides are prone to a detrimental side reaction referred to as aglycon transfer. In this letter, it is shown that aglycon transfer can be blocked by matching thioglycoside-containing acceptors with more armed glycosyl donors. Published by Elsevier Ltd.

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External Sources

  1. DOI: 10.1016/j.tetlet.2006.11.126
  2. WOS: 000243704000010

Library Notes

  1. No notes added.
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