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Molecular mechanisms of simian immunodeficiency virus SIVagm RNA encapsidation

  1. Author:
    Fu, W.
    Prasad, V.
    Chen, J. B.
    Nikolaitchik, O.
    Hu, W. S.

  2. Author Address

    Natl Canc Inst, HIV Drug Resistance Program, Ft Detrick, MD 21702 USA.;Hu, WS, Natl Canc Inst, HIV Drug Resistance Program, Ft Detrick, MD 21702 USA.;whu@ncifcrf.gov
    1. Year: 2007
    2. Date: Jun
  2. Journal: Virology
    1. 363
    2. 1
    3. Pages: 210-219
  4. Type of Article: Article
  5. ISSN: 0042-6822
  1. Abstract:

    Primate lentiviruses are composed of several distinct lineages, including human immunodeficiency virus type 1 (HIV-1), HIV-2, and simian immunodeficiency virus SIVagm. HIV-1 and HIV-2 have significant differences in the mechanisms of viral RNA encapsidation. Therefore, the RNA packaging mechanisms of SIVagm cannot be predicted from the studies of HIV-1 and HIV-2. We examined the roles of the nucleocapsid (NC) zinc finger motifs on RNA packaging by mutating the conserved zinc finger (CCHC) motifs, and whether SIVagin has a preference to package RNA in cis by comparing the RNA packaging efficiencies of gag mutants in the presence of a wild-type vector. Our results indicate that the SIVagm NC domain plays an important role in Gag-RNA recognition; furthermore SIVagm. is distinct from the other currently known primate lentiviruses as destroying either zinc finger motif in the NC causes very drastic RNA packaging defects. Additionally, trans-packaging is a major mechanism for SIVagm RNA encapsidation. Published by Elsevier Inc.

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External Sources

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  2. DOI: 10.1016/j.virol.2007.01.030
  3. View record in Web of Science®
  4. WOS: 000246936000021

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