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A panel of families identified for genetic linkage analysis of hereditary papillary renal carcinoma

  1. Author:
    Schmidt, L.
    Glenn, G.
    Choyke, P.
    Bergerheim, U.
    Lips, C. J. M.
    Linehan, W. M.
    Zbar, B.
    1. Year of Conference: 1997
  2. Conference Name: Annual Meeting of the American Association for Cancer Research
    1. 38
    2. Pages: A3072
  4. Type of Work: Meeting Abstract
  1. Abstract:

    Hereditary papillary renal carcinoma (HPRC) is a form of inherited kidney cancer characterized by a predisposition to develop multiple, bilateral renal tumors with a papillary histology. Papillary renal tumors show a characteristic trisomy of chromosomes 7 and 17, and loss of Y in males. Unlike clear cell renal carcinoma, neither genetic linkage to chromosome 3p nor loss of heterozygosity on chromosome 3 has been observed in HPRC. In order to identify the location of the disease gene for this rare form of kidney cancer, we have collected five families for linkage analysis, each with at least two affected members who have papillary renal carcinoma. The panel consisted of 77 family members, 27 of whom were affected and for whom DNA was available. Genotyping data, analyzed with the LINKAGE program, version 5.1, will be presented.

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