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Natural product scaffolds as leads-to drugs

  1. Author:
    Newman, D. J.
    Cragg, G. M.

  2. Author Address

    [Newman, David J.; Cragg, Gordon M.] NCI, Nat Prod Branch, Dev Therapeut Program, Frederick, MD 21702 USA.;Newman, DJ, NCI, Nat Prod Branch, Dev Therapeut Program, Frederick, MD 21702 USA.;dn22a@nih.gov
    1. Year: 2009
    2. Date: Nov
  2. Journal: Future Medicinal Chemistry
    1. 1
    2. 8
    3. Pages: 1415-1427
  4. Type of Article: Review
  5. ISSN: 1756-8919
  1. Abstract:

    Numerous 'scaffolds' that have been identified in natural product structures have led to very significant numbers of approved drugs and drug candidates for a multiplicity of diseases over the years. In this mini-review, we discuss the base scaffolds (chemical skeletons) that we feel have produced very significant numbers of agents as drugs or drug leads and, in a number of cases, compounds that can be used as chemical synthons or that present activities in biological areas that were not obvious from their earlier history.

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External Sources

  1. View Full Text
  2. DOI: 10.4155/fmc.09.113
  3. View record in Web of Science®
  4. WOS: 000276094100012

Library Notes

  1. Fiscal Year: FY2009-2010
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