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A dual role of Cdk2 in DNA damage response

  1. Author:
    Satyanarayana, A.
    Kaldis, P.

  2. Author Address

    [Satyanarayana, Ande] NCI, Mouse Canc Genet Program, Ctr Canc Res, Frederick, MD 21702 USA. [Kaldis, Philipp] Proteos, IMCB, Singapore 138673, Singapore.;Satyanarayana, A, NCI, Mouse Canc Genet Program, Ctr Canc Res, Bldg 560-22-69,1050 Boyles St, Frederick, MD 21702 USA.;satya@ncifcrf.gov kaldis@imcb.a-star.edu.sg
    1. Year: 2009
    2. Date: May
  2. Journal: Cell Division
    1. 4
    2. Pages: 4
  4. Type of Article: Article
  5. Article Number: 9
  6. ISSN: 1747-1028
  1. Abstract:

    Once it was believed that Cdk2 was the master regulator of S phase entry. Gene knockout mouse studies of cell cycle regulators revealed that Cdk2 is dispensable for S phase initiation and progression whereby Cdk1 can compensate for the loss of Cdk2. Nevertheless, recent evidence indicates that Cdk2 is involved in cell cycle independent functions such as DNA damage repair. Whether these properties are unique to Cdk2 or also being compensated by other Cdks in the absence of Cdk2 is under extensive investigation. Here we review the emerging new role of Cdk2 in DNA damage repair and also discuss how the loss of Cdk2 impacts the G(1)/S phase DNA damage checkpoint.

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External Sources

  1. View Full Text
  2. DOI: 10.1186/1747-1028-4-9
  3. View record in Web of Science®
  4. WOS: 000283780700001

Library Notes

  1. Fiscal Year: FY2008-2009
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