Skip NavigationSkip to Content
Return Return to Search Results

Study on the potential anti-cancer activity of phosphonium and ammonium-based ionic liquids

  1. Author:
    Kumar, V.
    Malhotra, S. V.

  2. Author Address

    Kumar, Vineet, Malhotra, Sanjay V.] NCI, Lab Synthet Chem, SAIC Frederick Inc, Frederick, MD 21702 USA.
    1. Year: 2009
  2. Journal: Bioorganic & Medicinal Chemistry Letters
    1. 19
    2. 16
    3. Pages: 4643-4646
  4. Type of Article: Article
  1. Abstract:

    The anti-cancer activity and cytotoxicity of phosphonium and ammonium-based ionic liquids (ILs) have been determined for the first time via NCI's in vitro 60 human tumor cell lines. The preliminary SAR showed that the chain length of alkyl substitution on the cations plays crucial role towards anti-tumor activity and cytotoxicity of these ionic liquids. In general, phosphonium-based ILs were found to be more active and less cytotoxic as compared to ammonium ILs. Cell line data and hollow fiber study has demonstrated the potential of ILs to be developed as therapeutic agent. (C) 2009 Elsevier Ltd. All rights reserved.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1016/j.bmcl.2009.06.086
  3. PMID: 19615902

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel