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A Sulfilimine Bond Identified in Collagen IV

  1. Author:
    Vanacore, R.
    Ham, A.
    Voehler, M.
    Sanders, C. R.
    Conrads, T. P.
    Veenstra, T. D.
    Sharpless, K. B.
    Dawson, P. E.
    Hudson, B. G.

  2. Author Address

    Vanacore, Roberto, Hudson, Billy G.] Vanderbilt Univ, Dept Med, Div Nephrol, Nashville, TN 37232 USA. [Vanacore, Roberto, Hudson, Billy G.] Vanderbilt Univ, Ctr Matrix Biol, Nashville, TN 37232 USA. [Ham, Amy-Joan L.; Sanders, Charles R.; Hudson, Billy G.] Vanderbilt Univ, Dept Biochem, Nashville, TN 37232 USA. [Voehler, Markus] Vanderbilt Univ, Dept Chem, Nashville, TN 37232 USA. [Hudson, Billy G.] Vanderbilt Univ, Dept Pathol, Nashville, TN 37232 USA. [Conrads, Thomas P.; Veenstra, Timothy D.] NCI, Lab Prote & Analyt Technol, Adv Technol Program, SAIC Frederick Inc, Frederick, MD 21702 USA. [Sharpless, K. Barry, Dawson, Philip E.] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA. [Sharpless, K. Barry, Dawson, Philip E.] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA. [Dawson, Philip E.] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA.
    1. Year: 2009
  2. Journal: Science
    1. 325
    2. 5945
    3. Pages: 1230-1234
  4. Type of Article: Article
  1. Abstract:

    Collagen IV networks are ancient proteins of basement membranes that underlie epithelia in metazoa from sponge to human. The networks provide structural integrity to tissues and serve as ligands for integrin cell-surface receptors. They are assembled by oligomerization of triple-helical protomers and are covalently crosslinked, a key reinforcement that stabilizes networks. We used Fourier-transform ion cyclotron resonance mass spectrometry and nuclear magnetic resonance spectroscopy to show that a sulfilimine bond (-S=N-) crosslinks hydroxylysine-211 and methionine-93 of adjoining protomers, a bond not previously found in biomolecules. This bond, the nitrogen analog of a sulfoxide, appears to have arisen at the divergence of sponge and cnidaria, an adaptation of the extracellular matrix in response to mechanical stress in metazoan evolution.

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  2. DOI: 10.1126/science.1176811
  3. PMID: 19729652

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