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Topically Applied Recombinant Chemokine Analogues Fully Protect Macaques from Vaginal Simian-Human Immunodeficiency Virus Challenge

  1. Author:
    Veazey, R. S.
    Ling, B. H.
    Green, L. C.
    Ribka, E. P.
    Lifson, J. D.
    Piatak, M.
    Lederman, M. M.
    Mosier, D.
    Offord, R.
    Hartley, O.

  2. Author Address

    Lederman, Michael M.] Case Western Reserve Univ, Cleveland, OH 44106 USA. [Veazey, Ronald S.; Ling, Binhua, Green, Linda C.; Ribka, Erin P.] Tulane Natl Primate Res Ctr, Covington, LA USA. [Lifson, Jeffrey D.; Piatak, Michael, Jr.] NCI, AIDS & Canc Virus Program, SAIC Frederick, Frederick, MD 21701 USA. [Mosier, Donald] Scripps Res Inst, La Jolla, CA USA. [Offord, Robin] Univ Geneva, Fac Med, Mintaka Fdn Med Res, Geneva, Switzerland. [Hartley, Oliver] Univ Geneva, Fac Med, Dept Struct Biol & Bioinformat, Geneva, Switzerland.
    1. Year: 2009
  2. Journal: Journal of Infectious Diseases
    1. 199
    2. 10
    3. Pages: 1525-1527
  4. Type of Article: Article
  1. Abstract:

    Effective strategies for preventing human immunodeficiency virus infection are urgently needed, but recent failures in key clinical trials of vaccines and microbicides highlight the need for new approaches validated in relevant animal models. Here, we show that 2 new chemokine (C-C motif) receptor 5 inhibitors, 5P12-RANTES (regulated on activation, normal T cell expressed and secreted) and 6P4-RANTES, fully protect against infection in the rhesus vaginal challenge model. These highly potent molecules, which are amenable to low-cost production, represent promising new additions to the microbicides pipeline.

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External Sources

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  2. DOI: 10.1086/598685
  3. PMID: 19331577

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