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Cytotoxic geranyl stilbenes from Macaranga schweinfurthii

  1. Author:
    Beutler, J. A.
    Shoemaker, R. H.
    Johnson, T.
    Boyd, M. R.

  2. Author Address

    Boyd MR NCI, Lab Drug Discovery Res & Dev, Dev Therapeut Program,Div Canc Treatment & Diag, Frederick Canc Res & Dev Ctr Frederick, MD 21702 USA NCI, Lab Drug Discovery Res & Dev, Dev Therapeut Program,Div Canc Treatment & Diag, Frederick Canc Res & Dev Ctr Frederick, MD 21702 USA
    1. Year: 1998
  2. Journal: Journal of Natural Products
    1. 61
    2. 12
    3. Pages: 1509-1512
  4. Type of Article: Article
  1. Abstract:

    Three novel geranyl stilbenes, schweinfurthins A, B, and C (1, 2, and 3), were isolated from the Cameroonian plant Macaranga schweinfurthii (Euphorbiaceae) and their structures determined by NMR and mass spectral methods. The cytotoxicity profile of the schweinfurthins tested in the NCI 60-cell screen was similar to that of the stelletins and cephalostatins, suggesting that these structurally diverse natural products may share similar mechanisms of cytotoxicity. [References: 16]

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