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Arsenic Exposure In Utero and Nonepidermal Proliferative Response in Adulthood in Tg.AC Mice

  1. Author:
    Tokar, E. J.
    Diwan, B. A.
    Waalkes, M. P.

  2. Author Address

    [Tokar, Erik J.; Waalkes, Michael P.] NIEHS, NCI, Res Triangle Pk, NC 27709 USA. [Diwan, Bhalchandra A.] NCI, SAIC Frederick Inc, Frederick, MD USA.;Waalkes, MP, NIEHS, NCI, 1,USA11 Alexander Dr, Res Triangle Pk, NC 27709 USA.;waalkes@niehs.nih.gov
    1. Year: 2010
    2. Date: May
  2. Journal: International Journal of Toxicology
    1. 29
    2. 3
    3. Pages: 291-296
  4. Type of Article: Article
  5. ISSN: 1091-5818
  1. Abstract:

    To expand our knowledge on the transplacental carcinogenic potential of inorganic arsenic, pregnant Tg.AC mice received drinking water with 0, 42.5, or 85 ppm arsenite from gestation day 8 to 18. After birth, groups (n = 25) of offspring received topical 12-O-tetradecanoyl phorbol-13-acetate (TPA) (2 mu g twice a week) for 36 weeks and were killed; nonskin tumors were assessed. Arsenic increased adrenal cortical adenomas (ACAs; 25%-29%) compared with control (0%) independent of TPA in all male groups. Arsenic increased urinary bladder (UB) hyperplasia in males, but only with TPA. Arsenic induced ACAs in all female groups (control 0%; arsenic 17%-26%). Arsenic-treated females had UB hyperplasia in most groups (control 0%; arsenic 26%-32%), with 2 UB papillomas. All arsenic-treated females had uterine hyperplasia (26%-40%; control 4%) independent of TPA, and 3 had uterine tumors. Thus, arsenic in utero rapidly induces ACAs and uterine and UB preneoplasias in Tg.AC mice, showing transplacental carcinogenic potential in yet another strain of mice.

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External Sources

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  2. DOI: 10.1177/1091581810362804
  3. View record in Web of Science®
  4. WOS: 000278124800006

Library Notes

  1. Fiscal Year: FY2009-2010
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