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Structural Model of the Pre-pore Ring-like Structure of Panton-Valentine Leukocidin: Providing Dimensionality to Biophysical and Mutational Data

  1. Author:
    Aman, M. J.
    Karauzum, H.
    Bowden, M. G.
    Nguyen, T. L.

  2. Author Address

    [Nguyen, Tam Luong] NCI, Target Struct Based Drug Discovery Grp, SAIC Frederick Inc, Frederick, MD 21702 USA. [Aman, M. Javad; Karauzum, Hatice] Integrated BioTherapeut Inc, Germantown, MD 20876 USA. [Bowden, M. Gabriela] Texas A&M Univ, Ctr Infect & Inflammatory Dis, Inst Biosci & Technol, Syst Hlth Sci Ctr, Houston, TX 77030 USA.;Nguyen, TL, NCI, Target Struct Based Drug Discovery Grp, SAIC Frederick Inc, Frederick, MD 21702 USA.;nguyent5@mail.nih.gov
    1. Year: 2010
    2. Date: Aug
  2. Journal: Journal of Biomolecular Structure & Dynamics
    1. 28
    2. 1
    3. Pages: 1-12
  4. Type of Article: Article
  5. ISSN: 0739-1102
  1. Abstract:

    Panton-Valentine leukocidin (PVL) is a bipartite toxin that plays an important role in the pathogenesis of methicillin-resistant Staphylococcus Queens. Recent clinical data suggest a correlation between PVL and severe cases of S. omens pneumonia. A clear understanding of the structure and function of PVL is critical to the development of novel. effective treatments. Here, we report an all-atom model or the macromolecular structure of Panton-Valentine leukocidin in its octamerie, pre-pore conformation that confirms and extends our understanding or the toxin's mechanism of action.

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External Sources

  1. View record in Web of Science®
  2. WOS: 000278516000001

Library Notes

  1. Fiscal Year: FY2009-2010
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