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The "Connection" Between HIV Drug Resistance and RNase H

  1. Author:
    Delviks-Frankenberry, K. A.
    Nikolenko, G. N.
    Pathak, V. K.

  2. Author Address

    [Delviks-Frankenberry, Krista A.; Nikolenko, Galina N.; Pathak, Vinay K.] NCI, Viral Mutat Sect, HIV Drug Resistance Program, Frederick, MD 21702 USA.;Pathak, VK, NCI, Viral Mutat Sect, HIV Drug Resistance Program, Frederick, MD 21702 USA.;frankenk@mail.nih.gov gnikolenko@comcast.net pathakv@mail.nih.gov
    1. Year: 2010
    2. Date: Jul
  2. Journal: Viruses-Basel
    1. 2
    2. 7
    3. Pages: 1476-1503
  4. Type of Article: Review
  5. ISSN: 1999-4915
  1. Abstract:

    Currently, nucleoside reverse transcriptase inhibitors (NRTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) are two classes of antiretroviral agents that are approved for treatment of HIV-1 infection. Since both NRTIs and NNRTIs target the polymerase (pol) domain of reverse transcriptase (RT), most genotypic analysis for drug resistance is limited to the first similar to 300 amino acids of RT. However, recent studies have demonstrated that mutations in the C-terminal domain of RT, specifically the connection subdomain and RNase H domain, can also increase resistance to both NRTIs and NNRTIs. In this review we will present the potential mechanisms by which mutations in the C-terminal domain of RT influence NRTI and NNRTI susceptibility, summarize the prevalence of the mutations in these regions of RT identified to date, and discuss their importance to clinical drug resistance.

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External Sources

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  2. DOI: 10.3390/v2071476
  3. View record in Web of Science®
  4. WOS: 000280413900009

Library Notes

  1. Fiscal Year: FY2009-2010
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