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Clerodane Diterpenes from Casearia arguta That Act As Synergistic TRAIL Sensitizers

  1. Author:
    Whitson, E. L.
    Thomas, C. L.
    Henrich, C. J.
    Sayers, T. J.
    McMahon, J. B.
    McKee, T. C.

  2. Author Address

    [Whitson, Emily L.; Thomas, Cheryl L.; Henrich, Curtis J.; McMahon, James B.; McKee, Tawnya C.] NCI, Mol Targets Lab, Mol Discovery Program, Ctr Canc Res, Frederick, MD 21702 USA. [Henrich, Curtis J.; Sayers, Thomas J.] SAIC Frederick Inc, Frederick, MD 21702 USA. [Sayers, Thomas J.] NCI, Expt Immunol Lab, Canc & Inflammat Program, Ctr Canc Res, Frederick, MD 21702 USA.;Mckee, TC, NCI, Mol Targets Lab, Mol Discovery Program, Ctr Canc Res, Frederick, MD 21702 USA.;mckeeta@mail.nih.gov
    1. Year: 2010
    2. Date: Dec
  2. Journal: Journal of Natural Products
    1. 73
    2. 12
    3. Pages: 2013-2018
  4. Type of Article: Article
  5. ISSN: 0163-3864
  1. Abstract:

    Casearia arguta was investigated as part of the ongoing search for synergistic TRAIL (tumor necrosis factor-a-related apoptosis-inducing ligand) sensitizers. As a result of this study, argutins A-H, eight new highly oxygenated clerodane diterpenes, were isolated from the plant Casearia arguta collected in Guatemala. The modified Mosher ester method was utilized to establish the absolute configuration of argutins A and F. Each of the argutins showed varying levels of synergy with TRAIL. Argutin B showed the highest TRAIL sensitization; the synergistic effect of argutin B and TRAIL together was 3-fold greater than argutin B alone.

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External Sources

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  2. DOI: 10.1021/np1004455
  3. View record in Web of Science®
  4. WOS: 000285560000008

Library Notes

  1. Fiscal Year: FY2010-2011
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