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Cd4(+) T-Lymphocyte Depletion in Human Lymphoid Tissue Ex Vivo Is Not Induced By Noninfectious Human Immunodeficiency Virus Type 1 Virions

  1. Author:
    Sylwester, A. W.
    Grivel, J. C.
    Fitzgerald, W.
    Rossio, J. L.
    Lifson, J. D.
    Margolis, L. B.

  2. Author Address

    Margolis LB SAIC FREDERICK AIDS VACCINE PROGRAM LAB RETROVIRAL PATHOGENESIS FREDERICK, MD 21702 USA SAIC FREDERICK AIDS VACCINE PROGRAM LAB RETROVIRAL PATHOGENESIS FREDERICK, MD 21702 USA NICHHD LAB CELLULAR & MOL BIOPHYS NIH BETHESDA, MD 20892 USA
    1. Year: 1998
  2. Journal: Journal of Virology
    1. 72
    2. 11
    3. Pages: 9345-9347
  4. Type of Article: Article
  1. Abstract:

    We tested infectious human immunodeficiency virus type 1 (HIV-I), noninfectious but conformationally authentic inactivated whole HIV-I virions, and purified gp120 for the ability to induce depletion of CD4(+) T cells in human lymphoid tissues ex vivo, Infectious CXCR4-tropic HIV-1, but not matched inactivated virions or gp120, mediated CD4(+) T-cell depletion, consistent with mechanisms requiring productive infection. [References: 31]

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