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Supramolecular complexes of quantum dots and a polyamidoamine (PAMAM)-folate derivative for molecular imaging of cancer cells

  1. Author:
    Geraldo, D. A.
    Duran-Lara, E. F.
    Aguayo, D.
    Cachau, R. E.
    Tapia, J.
    Esparza, R.
    Yacaman, M. J.
    Gonzalez-Nilo, F. D.
    Santos, L. S.

  2. Author Address

    [Geraldo, Daniela A.; Duran-Lara, Esteban F.; Tapia, Jaime; Santos, Leonardo S.] Univ Talca, Lab Asymmetr Synth, Chem Inst Nat Resources, Talca, Chile. [Geraldo, Daniela A.; Gonzalez-Nilo, Fernando Danilo] Univ Talca, Ctr Bioinformat & Mol Simulat, Talca, Chile. [Cachau, Raul E.] NCI, Sci Applicat Int Corp SAIC Frederick Inc, Frederick, MD 21702 USA. [Esparza, Rodrigo; Yacaman, Miguel J.] Univ Texas San Antonio, Dept Phys & Astron, San Antonio, TX 78249 USA.;Santos, LS, Univ Talca, Lab Asymmetr Synth, Chem Inst Nat Resources, POB 747, Talca, Chile.;lssantos@utalca.cl
    1. Year: 2011
    2. Date: Apr
  2. Journal: Analytical and Bioanalytical Chemistry
    1. 400
    2. 2
    3. Pages: 483-492
  4. Type of Article: Article
  5. ISSN: 1618-2642
  1. Abstract:

    Polyamidoamine (PAMAM) dendrimers and water-soluble 3-mercaptopropionic acid (MPA)-capped CdSe quantum dots (QDs) were combined to produce a new gel containing supramolecular complexes of QDs/PAMAM dendrimers. The formation of the QDs/PAMAM supramolecular complexes was confirmed by high resolution electron microscopy and Fourier transform infrared (FTIR) analyses. Molecular dynamics simulations corroborated the structure of the new QDs/PAMAM-based supramolecular compound. Finally, on the basis of the prominent fluorescent properties of the supramolecular complexes, PAMAM dendrimer was functionalized with folic acid to produce a new QDs/PAMAM-folate derivative that showed an efficient and selective performance as a marker for gastric cancer cells.

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External Sources

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  2. DOI: 10.1007/s00216-011-4756-2
  3. View record in Web of Science®
  4. WOS: 000289000300021

Library Notes

  1. Fiscal Year: FY2010-2011
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