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  1. 1.   Design, Synthesis and Biological Evaluation of 2-Phenyl Indole Analogues of OXi8006 as Colchicine Site Inhibitors of Tubulin Polymerization and Vascular Disrupting Agents
  2. Vairin, Rebecca; Tamminga, Caleb; Shi, Zhe; Borchardt, Christian; Jambulapati, Jayaram; Bai, Ruoli; Wanniarachchi, Hashini; Bueno, Lorena; Hamel,Ernest; Mason, Ralph P; Trawick, Mary Lynn; Pinney, Kevin G
  3. Bioorganic & Medicinal Chemistry. 2024, Nov 07; 118: 117981.
  1. 2.   Synthesis and Biological Evaluation of Novel 2-Aroyl Benzofuran-Based Hydroxamic Acids as Antimicrotubule Agents
  2. Mariotto, Elena; Canton, Martina; Marchioro, Chiara; Brancale, Andrea; Hamel,Ernest; Varani, Katia; Vincenzi, Fabrizio; De Ventura, Tiziano; Padroni, Chiara; Viola, Giampietro; Romagnoli, Romeo
  3. International Journal of Molecular Sciences. 2024, Jul 09; 25(14):
  1. 3.   Complex Tumor Spheroids, a Tissue-Mimicking Tumor Model, for Drug Discovery and Precision Medicine
  2. Kaur, Gurmeet; Evans, David M.; Teicher, Beverly A.; Coussens,Nathan
  3. SLAS Discovery. 2021, Nov 12;
  1. 4.   Recent advances in nanoparticles mediated photothermal therapy induced tumor regression
  2. Kumar, Achalla Vaishnav Pavan; Dubey, Sunil K.; Tiwari, Sanjay; Puri,Anu; Hejmady, Siddhanth; Gorain, Bapi; Kesharwani, Prashant
  3. International Journal of Pharmaceutics. 2021, Sep 5; 606
  1. 5.   Deciphering the chemical instability of sphaeropsidin A under physiological conditions - degradation studies and structural elucidation of the major metabolite
  2. van der Westhuyzen, Alet E; Ingels, Aude; Rosière, Rémi; Amighi, Karim; Oberer, Lukas; Gustafson,Kirk; Wang,Dongdong; Evidente, Antonio; Maddau, Lucia; Masi, Marco; de Villiers, André; Green, Ivan R; Berger, Walter; Kornienko, Alexander; Mathieu, Veronique; van Otterlo, Willem A L
  3. Organic & biomolecular chemistry. 2020, OCT 28; 18(40): 8147-8160.
  1. 6.   Synthetic, Structural, and Anticancer Activity Evaluation Studies on Novel Pyrazolylnucleosides
  2. Yadav, Yogesh; Sharma, Deepti; Kaushik, Kumar; Kumar, Vineet; Jha, Amitabh; Prasad, Ashok K; Len, Christophe; Malhotra, Sanjay V; Wengel, Jesper; Parmar, Virinder S
  3. Molecules (Basel, Switzerland). 2019, Nov; 24(21): pii: E3922.
  1. 7.   Nitric Oxide Donor DETA/NO Inhibits the Growth of Endometrial Cancer Cells by Upregulating the Expression of RASSF1 and CDKN1A
  2. Waheed, Sana; Cheng, Robert Ys; Casablanca, Yovanni; Maxwell, G Larry; Wink,David; Syed, Viqar
  3. Molecules (Basel, Switzerland). 2019, Oct 16; 24(20): pii: E3722..
  1. 8.   Specific RITA modification produces hyperselective cytotoxicity while maintaining in vivo antitumor efficacy
  2. Peyser,Brian; Hermone,Ann; Salamoun, Joseph M; Burnett, James C; Hollingshead,Melinda; McGrath,Connor; Gussio,Rick; Wipf, Peter
  3. Molecular cancer therapeutics. 2019, OCT; 18(10): 1765-1774.
  1. 9.   Synthesis and biological evaluation of indole-2-carbohydrazides and thiazolidinyl-indole-2-carboxamides as potent tubulin polymerization inhibitors
  2. Kazan, Fusun; Yagci, Z Begum; Bai,Ruoli; Ozkirimli, Elif; Hamel,Ernest; Ozkirimli, Sumru
  3. Computational biology and chemistry. 2019, Jun; 80: 512-523.
  1. 10.   Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2-d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors
  2. Romagnoli, Romeo; Prencipe, Filippo; Oliva, Paola; Baraldi, Stefania; Baraldi, Pier Giovanni; Schiaffino Ortega, Santiago; Chayah, Mariem; Kimatrai Salvador, Maria; Carlota Lopez-Cara, Luisa; Brancale, Andrea; Ferla, Salvatore; Hamel,Ernest; Ronca, Roberto; Bortolozzi, Roberta; Mariotto, Elena; Mattiuzzo, Elena; Viola, Giampietro
  3. JOURNAL OF MEDICINAL CHEMISTRY. 2019, Feb 14; 62(3): 1274-1290.
  1. 11.   Synthesis and Biological Evaluation of New Madecassic Acid Derivatives Targeting ERK Cascade Signaling
  2. Valdeira, Ana S C; Ritt,Daniel; Morrison,Deborah; McMahon, James B; Gustafson, Kirk R; Salvador, Jorge A R
  3. Frontiers in chemistry. 2018, Sep 28; 6: 434.
  1. 12.   Overexpression of IL-38 protein in anticancer drug-induced lung injury and acute exacerbation of idiopathic pulmonary fibrosis
  2. Tominaga, Masaki; Okamoto, Masaki; Kawayama, Tomotaka; Matsuoka, Masanobu; Kaieda, Shinjiro; Sakazaki, Yuki; Kinoshita, Takashi; Mori, Daisuke; Inoue, Akira; Hoshino, Tomoaki
  3. Respiratory Investigation. 2017, Sep; 55(5): 293-299.
  1. 13.   Growth-inhibitory and chemosensitizing effects of the glutathione-S-transferase-p-activated nitric oxide donor PABA/NO in malignant gliomas
  2. Kogias, E.; Osterberg, N.; Baumer, B.; Psarras, N.; Koentges, C.; Papazoglou, A.; Saavedra, J. E.; Keefer, L. K.; Weyerbrock, A.
  3. International Journal of Cancer. 2012, Mar; 130(5): 1184-1194.
  1. 14.   Antineoplastic Agents. 548. Synthesis of lodo- and Diiodocombstatin Phosphate Prodrugs
  2. Pettit, G. R.; Rosenberg, H. J.; Dixon, R.; Knight, J. C.; Hamel, E.; Chapuis, J. C.; Pettit, R. K.; Hogan, F.; Sumner, B.; Ain, K. B.; Trickey-Platt, B.
  3. Journal of Natural Products. 2012, Mar; 75(3): 385-393.
  1. 15.   Synergistic TRAIL Sensitizers from Barleria alluaudii and Diospyros maritima
  2. Whitson, E. L.; Sun, H.; Thomas, C. L.; Henrich, C. J.; Sayers, T. J.; McMahon, J. B.; Griesinger, C.; McKee, T. C.
  3. Journal of Natural Products. 2012, Mar; 75(3): 394-399.
  1. 16.   Antiangiogenic and antitumor activity of LP-261, a novel oral tubulin binding agent, alone and in combination with bevacizumab
  2. Gardner, E. R.; Kelly, M.; Springman, E.; Lee, K. J.; Li, H. Q.; Moore, W.; Figg, W. D.
  3. Investigational New Drugs. 2012, Feb; 30(1): 90-97.
  1. 17.   Steroidomimetic Tetrahydroisoquinolines for the Design of New Microtubule Disruptors
  2. Leese, M. P.; Jourdan, F.; Dohle, W.; Kimberley, M. R.; Thomas, M. P.; Bai, R. L.; Hamel, E.; Ferrandis, E.; Potter, B. V. L.
  3. Acs Medicinal Chemistry Letters. 2012, Jan; 3(1): 5-9.
  1. 18.   Design and Synthesis of 2-Heterocyclyl-3-arylthio-1H-indoles as Potent Tubulin Polymerization and Cell Growth Inhibitors with Improved Metabolic Stability
  2. La Regina, G.; Bai, R.; Rensen, W.; Coluccia, A.; Piscitelli, F.; Gatti, V.; Bolognesi, A.; Lavecchia, A.; Granata, I.; Porta, A.; Maresca, B.; Soriani, A.; Iannitto, M. L.; Mariani, M.; Santoni, A.; Brancale, A.; Ferlini, C.; Dondio, G.; Varasi, M.; Mercurio, C.; Hamel, E.; Lavia, P.; Novellino, E.; Silvestri, R.
  3. Journal of Medicinal Chemistry. 2011, Dec; 54(24): 8394-8406.
  1. 19.   Non-coding rRNA-mediated preferential killing in cancer cells is enhanced by suppression of autophagy in non-transformed counterpart
  2. Hwang, C. J.; Fields, J. R.; Shiao, Y. H.
  3. Cell Death & Disease. 2011, Dec; 2
  1. 20.   The cancer stem cell niche-there goes the neighborhood?
  2. Cabarcas, S. M.; Mathews, L. A.; Farrar, W. L.
  3. International Journal of Cancer. 2011, Nov; 129(10): 2315-2327.
  1. 21.   DNA intercalator korkormicin A preferentially kills tumor cells expressing wild type p53
  2. Kitagaki, J.; Yang, Y. L.
  3. Biochemical and Biophysical Research Communications. 2011, Oct; 414(1): 186-191.
  1. 22.   Synthesis and Anticancer Activity of 13-Membered Cyclic Enediynes
  2. Sharma, M.; Joshi, M. C.; Kumar, V.; Malhotra, S. V.; Rawat, D. S.
  3. Archiv Der Pharmazie. 2011, Sep; 344(9): 564-571.
  1. 23.   Discovery of 7-Hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a Tubulin Polymerization Inhibitor with Potent Antiproliferative and Tumor Vascular Disrupting Properties
  2. Flynn, B. L.; Gill, G. S.; Grobelny, D. W.; Chaplin, J. H.; Paul, D.; Leske, A. F.; Lavranos, T. C.; Chalmers, D. K.; Charman, S. A.; Kostewicz, E.; Shackleford, D. M.; Morizzi, J.; Hamel, E.; Jung, M. K.; Kremmidiotis, G.
  3. Journal of Medicinal Chemistry. 2011, Sep; 54(17): 6014-6027.
  1. 24.   N-Hydroxyethyl-4-aza-didehydropodophyllotoxin derivatives as potential antitumor agents
  2. Kumar, A.; Kumar, V.; Alegria, A. E.; Malhotra, S. V.
  3. European Journal of Pharmaceutical Sciences. 2011, Sep; 44(1-2): 21-26.
  1. 25.   HER2-Affitoxin: A Potent Therapeutic Agent for the Treatment of HER2-Overexpressing Tumors
  2. Zielinski, R.; Lyakhov, I.; Hassan, M.; Kuban, M.; Shafer-Weaver, K.; Gandjbakhche, A.; Capala, J.
  3. Clinical Cancer Research. 2011, Aug; 17(15): 5071-5081.
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