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  1. 1.   Unusual Vilasinin-Class Limonoids from Trichilia rubescens
  2. Amuti, Saidanxia; Saito, Yohei; Fukuyoshi, Shuichi; Miyake, Katsunori; Newman,Dave; O'Keefe,Barry; Lee, Kuo-Hsiung; Nakagawa-Goto, Kyoko
  3. Molecules (Basel, Switzerland). 2024, Jan 30; 29(3):
  1. 2.   Synthesis and Biological Evaluation of Highly Active 7-Anilino Triazolopyrimidines as Potent Antimicrotubule Agents
  2. Oliva, Paola; Romagnoli, Romeo; Cacciari, Barbara; Manfredini, Stefano; Padroni, Chiara; Brancale, Andrea; Ferla, Salvatore; Hamel,Ernest; Corallo, Diana; Aveic, Sanja; Milan, Noemi; Mariotto, Elena; Viola, Giampietro; Bortolozzi, Roberta
  3. Pharmaceutics. 2022, Jun 02; 14(6):
  1. 3.   Effects of substituent pattern on the intracellular target of antiproliferative benzo[b]thiophenyl chromone derivatives
  2. Saito, Yohei; Taniguchi, Yukako; Hirazawa, Sachika; Miura, Yuta; Tsurimoto, Hiroyuki; Nakayoshi, Tomoki; Oda, Akifumi; Hamel,Ernest; Yamashita, Katsumi; Goto, Masuo; Nakagawa-Goto, Kyoko
  3. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2021, OCT 15; 222
  1. 4.   A facile synthesis of diaryl pyrroles led to the discovery of potent colchicine site antimitotic agents
  2. Romagnoli, Romeo; Oliva, Paola; Salvador, Maria Kimatrai; Manfredini, Stefano; Padroni, Chiara; Brancale, Andrea; Ferla, Salvatore; Hamel,Ernest; Ronca, Roberto; Maccarinelli, Federica; Rruga, Fatlum; Mariotto, Elena; Viola, Giampietro; Bortolozzi, Roberta
  3. European Journal of Medicinal Chemistry. 2021, Mar 15; 214
  1. 5.   Pyrrolo[2 ',3 ':3,4]cyclohepta[1,2-d][1,2]oxazoles, a New Class of Antimitotic Agents Active against Multiple Malignant Cell Types
  2. Spano, Virginia; Rocca, Roberta; Barreca, Marilia; Giallombardo, Daniele; Montalbano, Alessandra; Carbone, Anna; Raimondi, Maria Valeria; Gaudio, Eugenio; Bortolozzi, Roberta; Bai,Ruoli; Tassone, Pierfrancesco; Alcaro, Stefano; Hamel,Ernest; Viola, Giampietro; Bertoni, Francesco; Barraja, Paola
  3. JOURNAL OF MEDICINAL CHEMISTRY. 2020, OCT 22; 63(20): 12023-12042.
  1. 6.   New complex polycyclic compounds: Synthesis, antiproliferative activity and mechanism of action
  2. Daidone, Giuseppe; D'Anneo, Antonella; Raimondi, Maria Valeria; Raffa, Demetrio; Hamel,Ernest; Plescia, Fabiana; Lauricella, Marianna; Maggio, Benedetta
  3. Bioorganic chemistry. 2020, AUG; 101: pii: 103989.
  1. 7.   Synthesis and Biological Evaluation of 2-Substituted Benzyl-/Phenylethylamino-4-amino-5-aroylthiazoles as Apoptosis-Inducing Anticancer Agents
  2. Oliva, Paola; Onnis, Valentina; Balboni, Elisa; Hamel,Ernest; Estévez-Sarmiento, Francisco; Quintana, José; Estévez, Francisco; Brancale, Andrea; Ferla, Salvatore; Manfredini, Stefano; Romagnoli, Romeo
  3. Molecules (Basel, Switzerland). 2020, May 06; 25(9):
  1. 8.   Synthesis and Biological Evaluation of New Antitubulin Agents Containing 2-(3',4',5'-trimethoxyanilino)-3,6-disubstituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine Scaffold
  2. Romagnoli, Romeo; Prencipe, Filippo; Oliva, Paola; Cacciari, Barbara; Balzarini, Jan; Liekens, Sandra; Hamel,Ernest; Brancale, Andrea; Ferla, Salvatore; Manfredini, Stefano; Zurlo, Matteo; Finotti, Alessia; Gambari, Roberto
  3. Molecules (Basel, Switzerland). 2020, Apr 07; 25(7): pii : molecules25071690.
  1. 9.   Design, synthesis and biological evaluation of 2-alkoxycarbonyl-3-anilinoindoles as a new class of potent inhibitors of tubulin polymerization
  2. Romagnoli, Romeo; Prencipe, Filippo; Oliva, Paola; Kimatrai Salvador, Maria; Brancale, Andrea; Ferla, Salvatore; Hamel,Ernest; Viola, Giampietro; Bortolozzi, Roberta; Persoons, Leentje; Balzarini, Jan; Liekens, Sandra; Schols, Dominique
  3. Bioorganic chemistry. 2020, APR; 97: 103665.
  1. 10.   Isolation, Structure Elucidation, and Antiproliferative Activity of Butanolides and Lignan Glycosides from the Fruit of Hernandia nymphaeifolia
  2. Aimaiti, Simayijiang; Saito, Yohei; Fukuyoshi, Shuichi; Goto, Masuo; Miyake, Katsunori; Newman, David J; O'Keefe,Barry; Lee, Kuo-Hsiung; Nakagawa-Goto, Kyoko
  3. Molecules (Basel, Switzerland). 2019, Nov 05; 24(21): pii: E4005. .
  1. 11.   Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors
  2. Romagnoli, Romeo; Oliva, Paola; Salvador, Maria Kimatrai; Camacho, Maria Encarnacion; Padroni, Chiara; Brancale, Andrea; Ferla, Salvatore; Hamel,Ernest; Ronca, Roberto; Grillo, Elisabetta; Bortolozzi, Roberta; Rruga, Fatlum; Mariotto, Elena; Viola, Giampietro
  3. European journal of medicinal chemistry. 2019, NOV 1; 181: 111577.
  1. 12.   Specific RITA modification produces hyperselective cytotoxicity while maintaining in vivo antitumor efficacy
  2. Peyser,Brian; Hermone,Ann; Salamoun, Joseph M; Burnett, James C; Hollingshead,Melinda; McGrath,Connor; Gussio,Rick; Wipf, Peter
  3. Molecular cancer therapeutics. 2019, OCT; 18(10): 1765-1774.
  1. 13.   Antiproliferative Aspidosperma-Type Monoterpenoid Indole Alkaloids from Bousigonia mekongensis Inhibit Tubulin Polymerization
  2. Zhang, Yu; Goto, Masuo; Oda, Akifumi; Hsu, Pei-Ling; Guo, Ling-Li; Fu, Yan-Hui; Morris-Natschke, Susan L.; Hamel,Ernest; Lee, Kuo-Hsiung; Hao, Xiao-Jiang
  3. Molecules (Basel, Switzerland). 2019, Mar 31; 24(7): pii: E1256.
  1. 14.   3-Aryl/Heteroaryl-5-amino-1-(3',4',5'-trimethoxybenzoyl)-1,2,4-triazoles as antimicrotubule agents. Design, synthesis, antiproliferative activity and inhibition of tubulin polymerization
  2. Romagnoli, Romeo; Prencipe, Filippo; Oliva, Paola; Baraldi, Stefania; Baraldi, Pier Giovanni; Brancale, Andrea; Ferla, Salvatore; Hamel, Ernest; Bortolozzi, Roberta; Viola, Giampietro
  3. Bioorganic chemistry. 2018, Oct; 80: 361-374.
  1. 15.   Synthesis and in vitro Evaluation of 3H-Pyrrolo[3,2-f]quinolin-9-one Derivatives That Show Potent and Selective Anti-leukemic Activity
  2. Ferlin, M. G.; Bortolozzi, R.; Brun, P.; Castagliuolo, I.; Hamel, E.; Basso, G.; Viola, G.
  3. Chemmedchem. 2010, Jul; 5(8): 1373-1385.
  1. 16.   Symmetrical alpha-bromoacryloylamido diaryldienone derivatives as a novel series of antiproliferative agents. Design, synthesis and biological evaluation
  2. Romagnoli, R.; Baraldi, P. G.; Cruz-Lopez, O.; Cara, C. L.; Carrion, M. D.; Balzarini, J.; Hamel, E.; Basso, G.; Bortolozzi, R.; Viola, G.
  3. Bioorganic & Medicinal Chemistry Letters. 2010, May; 20(9): 2733-2739.
  1. 17.   Covalent binding to tubulin by isothiocyanates - A mechanism of cell growth arrest and apoptosis
  2. Mi, L. X.; Xiao, Z.; Hood, B. L.; Dakshanamurthy, S.; Wang, X. T.; Govind, S.; Conrads, T. P.; Veenstra, T. D.; Chung, F. L.
  3. Journal of Biological Chemistry. 2008 283(32): 22136-22146.
  1. 18.   Synthesis and Biological Evaluation of 2-aroyl-4-phenyl-5-hydroxybenzofurans as a New Class of Antitubulin Agents
  2. Romagnoli, R.; Baraldi, P. G.; Sarkar, T.; Cara, C. L.; Lopez, O. C.; Carrion, M. D.; Preti, D.; Tolomeo, M.; Balzarini, J.; Hamel, E.
  3. Medicinal Chemistry. 2008 4(6): 558-564.
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