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  1. 1.   Distinct allosteric networks in CDK4 and CDK6 in the cell cycle and in drug resistance
  2. Zhang,Wengang; Bradburn, Devin; Heidebrink, Gretchen; Liu, Yonglan; Jang,Hyunbum; Nussinov,Ruth; Kõivomägi, Mardo
  3. Journal of Molecular Biology. 2025, Mar 31; 169121.
  1. 2.   Slower CDK4 and faster CDK2 activation in the cell cycle
  2. Zhang,Wengang; Liu,Yonglan; Jang,Hyunbum; Nussinov,Ruth
  3. Structure (London, England : 1993). 2024, Apr 23;
  1. 3.   CDK2 inhibition disorders centrosome stoichiometry and alters cellular outcomes in aneuploid cancer cells
  2. Chen,Zibo; Liu,Xi; Kawakami, Masanori; Liu,Xiuxia; Baker, Allison; Bhatawadekar, Aayush; Tyutyunyk-Massey,Liliya; Narayan,Kedar; Dmitrovsky,Ethan
  3. Cancer Biology & Therapy. 2023, Dec 31; 24(1): 2279241.
  1. 4.   3'-[18F]fluoro-3'-deoxythymidine ([18F]FLT) Positron Emission Tomography as an In Vivo Biomarker of inhibition of CDK 4/6-Rb pathway by Palbociclib in a patient derived bladder tumor
  2. Tatum, James L; Kalen,Joseph; Jacobs, Paula M; Riffle,Lisa; James,Amy; Thang,Lai; Sanders,Chelsea; Hollingshead,Melinda; Basuli, Falguni; Shi, Jianfeng; Doroshow, James H
  3. Journal of Translational Medicine. 2022, Aug 18; 20(1): 375.
  1. 5.   Sensitivity of Oncogenic KRAS-Expressing Cells to CDK9 Inhibition
  2. Lai, Lick Pui; Brel, Viviane; Sharma, Kanika; Frappier, Julia; Le-Henanf, Nadia; Vivet, Bertrand; Muzet, Nicolas; Schell, Emilie; Morales, Renaud; Rooney, Eamonn; Basse, Nicolas; Yi,Ming; Lacroix, Frederic; Holderfield, Matthew; Englaro, Walter; Marcireau, Christophe; Debussche, Laurent; Nissley,Dwight; McCormick, Frank
  3. SLAS DISCOVERY. 2021, Apr 24; 26(7, SI): 922-932.
  1. 6.   Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
  2. Krug, Karsten; Jaehnig, Eric J; Satpathy, Shankha; Blumenberg, Lili; Karpova, Alla; Anurag, Meenakshi; Miles, George; Mertins, Philipp; Geffen, Yifat; Tang, Lauren C; Heiman, David I; Cao, Song; Maruvka, Yosef E; Lei, Jonathan T; Huang, Chen; Kothadia, Ramani B; Colaprico, Antonio; Birger, Chet; Wang, Jarey; Dou, Yongchao; Wen, Bo; Shi, Zhiao; Liao, Yuxing; Wiznerowicz, Maciej; Wyczalkowski, Matthew A; Chen, Xi Steven; Kennedy, Jacob J; Paulovich, Amanda G; Thiagarajan,Mathangi; Kinsinger, Christopher R; Hiltke, Tara; Boja, Emily S; Mesri, Mehdi; Robles, Ana I; Rodriguez, Henry; Westbrook, Thomas F; Ding, Li; Getz, Gad; Clauser, Karl R; Fenyö, David; Ruggles, Kelly V; Zhang, Bing; Mani, D R; Carr, Steven A; Ellis, Matthew J; Gillette, Michael A
  3. Cell. 2020, NOV 25; 183(5): 1436-+.
  1. 7.   Stabilization of p27Kip1/CDKN1B by UBCH7/UBE2L3 catalyzed ubiquitinylation: a new paradigm in cell-cycle control
  2. Whitcomb, Elizabeth A; Tsai, Yien Che; Basappa, Johnvesly; Liu, Ke; Le Feuvre, Aurélie K; Weissman, Allan; Taylor, Allen
  3. FASEB Journal. 2019, Jan; 33(1): 1235-1247.
  1. 8.   The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma
  2. Ricketts, Christopher J; De Cubas, Aguirre A; Fan, Huihui; Smith, Christof C; Lang, Martin; Reznik, Ed; Bowlby, Reanne; Gibb, Ewan A; Akbani, Rehan; Beroukhim, Rameen; Bottaro, Donald P; Choueiri, Toni K; Gibbs, Richard A; Godwin, Andrew K; Haake, Scott; Hakimi, A Ari; Henske, Elizabeth P; Hsieh, James J; Ho, Thai H; Kanchi, Rupa S; Krishnan, Bhavani; Kwaitkowski, David J; Lui, Wembin; Merino, Maria J; Mills, Gordon B; Myers, Jerome; Nickerson, Michael L; Reuter, Victor E; Schmidt, Laura S; Shelley, C Simon; Shen, Hui; Shuch, Brian; Signoretti, Sabina; Srinivasan, Ramaprasad; Tamboli, Pheroze; Thomas, George; Vincent, Benjamin G; Vocke, Cathy D; Wheeler, David A; Yang, Lixing; Kim, William T; Robertson, A Gordon; Spellman, Paul T; Rathmell, W Kimryn; Linehan, W Marston
  3. Cell Reports. 2018, Apr 03; 23(1): 313-326.e5.
  1. 9.   CDK10 Mutations in Humans and Mice Cause Severe Growth Retardation, Spine Malformations, and Developmental Delays.
  2. Windpassinger, Christian; Piard, Juliette; Bonnard, Carine; Alfadhel, Majid; Lim, Shuhui; Bisteau, Xavier; Blouin, Stéphane; Ali, Nur'Ain B; Ng, Alvin Yu Jin; Lu, Hao; Tohari, Sumanty; Talib, S Zakiah A; van Hul, Noémi; Caldez, Matias J; Van Maldergem, Lionel; Yigit, Gökhan; Kayserili, Hülya; Youssef, Sameh A; Coppola, Vincenzo; de Bruin, Alain; Tessarollo, Lino; Choi, Hyungwon; Rupp, Verena; Roetzer, Katharina; Roschger, Paul; Klaushofer, Klaus; Altmüller, Janine; Roy, Sudipto; Venkatesh, Byrappa; Ganger, Rudolf; Grill, Franz; Ben Chehida, Farid; Wollnik, Bernd; Altunoglu, Umut; Al Kaissi, Ali; Reversade, Bruno; Kaldis, Philipp
  3. American journal of human genetics. 2017, Sep 07; 101(3): 391-403.
  1. 10.   Emi2 Is Essential for Mouse Spermatogenesis
  2. Gopinathan, Lakshmi; Szmyd, Radoslaw; Low, Diana; Diril, M Kasim; Chang, Heng-Yu; Coppola, Vincenzo; Liu, Kui; Tessarollo, Lino; Guccione, Ernesto; van Pelt, Ans M M; Kaldis, Philipp
  3. Cell Reports. 2017, Jul 18; 20(3): 697-708.
  1. 11.   Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase I independent of Cdk2 activation.
  2. Tu, Zhaowei; Bayazit, Mustafa Bilal; Liu, Hongbin; Zhang, Jingjing; Busayavalasa, Kiran; Risal, Sanjiv; Shao, Jingchen; Satyanarayana, Ande; Coppola, Vincenzo; Tessarollo, Lino; Singh, Meenakshi; Zheng, Chunwei; Han, Chunsheng; Chen, Zijiang; Kaldis, Philipp; Gustafsson, Jan-Åke; Liu, Kui
  3. Proceedings of the National Academy of Sciences of the United States of America. 2017, Jan 17; 114(3): 592-597.
  1. 12.   Open Data, Open Source and Open Standards in chemistry: The Blue Obelisk five years on
  2. O'Boyle, N. M.; Guha, R.; Willighagen, E. L.; Adams, S. E.; Alvarsson, J.; Bradley, J. C.; Filippov, I. V.; Hanson, R. M.; Hanwell, M. D.; Hutchison, G. R.; James, C. A.; Jeliazkova, N.; Lang, A.; Langner, K. M.; Lonie, D. C.; Lowe, D. M.; Pansanel, J.; Pavlov, D.; Spjuth, O.; Steinbeck, C.; Tenderholt, A. L.; Theisen, K. J.; Murray-Rust, P.
  3. Journal of Cheminformatics. 2011, Oct; 3
  1. 13.   Lack of germline PALB2 mutations in melanoma-prone families with CDKN2A mutations and pancreatic cancer
  2. Yang, X. H. R.; Jessop, L.; Myers, T.; Amundadottir, L.; Pfeiffer, R. M.; Wheeler, W.; Pike, K. M.; Yuenger, J.; Burdett, L.; Yeager, M.; Chanock, S. J.; Tucker, M. A.; Goldstein, A. M.
  3. Familial Cancer. 2011, Sep; 10(3): 545-548.
  1. 14.   Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations
  2. Yang, X. R.; Liang, X. Y.; Pfeiffer, R. M.; Wheeler, W.; Maeder, D.; Burdette, L.; Yeager, M.; Chanock, S.; Tucker, M. A.; Goldstein, A. M.
  3. Familial Cancer. 2010, Dec; 9(4): 625-633.
  1. 15.   Cdk2 plays a critical role in hepatocyte cell cycle progression and survival in the setting of cyclin D1 expression in vivo
  2. Hanse, E. A.; Nelsen, C. J.; Goggin, M. M.; Anttila, C. K.; Mullany, L. K.; Berthet, C.; Kaldis, P.; Crary, G. S.; Kuriyama, R.; Albrecht, J. H.
  3. Cell Cycle. 2009 8(17): 2802-2809.
  1. 16.   Rb/Cdk2/Cdk4 triple mutant mice elicit an alternative mechanism for regulation of the G(1)/S transition
  2. Li, W.; Kotoshiba, S.; Berthet, C.; Hilton, M. B.; Kaldis, P.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2009 106(2): 486-491.
  1. 17.   Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms
  2. Satyanarayana, A.; Kaldis, P.
  3. Oncogene. 2009 28(33): 2925-2939.
  1. 18.   Cyclin-dependent kinase 5 phosphorylation of human septin SEPT5 (hCDCrel-1) modulates exocytosis
  2. Amin, N. D.; Zheng, Y. L.; Kesavapany, S.; Kanungo, J.; Guszczynski, T.; Sihag, R. K.; Rudrabhatla, P.; Albers, W.; Grant, P.; Pant, H. C.
  3. Journal of Neuroscience. 2008 28(14): 3631-3643.
  1. 19.   Genetic substitution of Cdk1 by Cdk2 leads to embryonic lethality and loss of meiotic function of Cdk2
  2. Satyanarayana, A.; Berthet, C.; Lopez-Molina, J.; Coppola, V.; Tessarollo, L.; Kaldis, P.
  3. Development. 2008 135(20): 3389-3400.
  1. 20.   Kinase-independent function of cyclin E
  2. Geng, Y.; Lee, Y. M.; Welcker, M.; Swanger, J.; Zagozdzon, A.; Winer, J. D.; Roberts, J. M.; Kaldis, P.; Clurman, B. E.; Sicinski, P.
  3. Molecular Cell. 2007, Jan; 25(1): 127-139.
  1. 21.   Another piece of the p27(Kip1) puzzle
  2. Kaldis, P.
  3. Cell. 2007, Jan; 128(2): 241-244.
  1. 22.   Dependence of cisplatin-induced cell death in vitro and in vivo on cyclin-dependent kinase 2
  2. Price, P. M.; Yu, F.; Kaldis, P.; Aleem, E.; Nowak, G.; Safirstein, R. L.; Megyesi, J.
  3. Journal of the American Society of Nephrology. 2006, Sep; 17(9): 2434-2442.
  1. 23.   CDK2 is required by MYC to induce apoptosis
  2. Deb-Basu, D.; Aleem, E.; Kaldis, P.; Felsher, D. W.
  3. Cell Cycle. 2006, Jun; 5(12): 1342-1347.
  1. 24.   Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation
  2. Berthet, C.; Klarmann, K. D.; Hilton, M. B.; Suh, H. C.; Keller, J. R.; Kiyokawa, H.; Kaldis, P.
  3. Developmental Cell. 2006, MAY; 10(5): 563-573.
  1. 25.   Cell cycling through Cdc25A - Transducer of cytokine proliferative signals
  2. Kittipatarin, C.; Li, W. Q.; Bulavin, D. V.; Durum, S. K.; Khaled, A. R.
  3. Cell Cycle. 2006, May; 5(9): 907-912.
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