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  1. 1.   WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells
  2. Datta, Arindam; Biswas, Kajal; Sommers, Joshua A.; Thompson, Haley; Awate, Sanket; Nicolae, Claudia M.; Thakar, Tanay; Moldovan, George-Lucian; Shoemaker, Robert H.; Sharan, Shyam K.; Brosh, Robert M.
  3. Nature Communications. 2021, Nov 12; 12(1):
  1. 2.   A novel mouse model of PMS2 founder mutation that causes mismatch repair defect due to aberrant splicing
  2. Biswas,Kajal; Couillard, Martin; Cavallone, Luca; Burkett,Sandra; Stauffer,Stacey; Martin, Betty K.; Southon,Eileen; Reid,Susan; Plona,Teri; Baugher,Ryan; Mellott,Stephanie; Pike,Kristen; Albaugh,Mary; Maedler-Kron, Chelsea; Hamel, Nancy; Tessarollo,Lino; Marcus, Victoria; Foulkes, William D.; Sharan,Shyam
  3. Cell Death & Disease. 2021, Sep 6; 12(9):
  1. 3.   Inhibition of the DNA damage response phosphatase PPM1D reprograms neutrophils to enhance anti-tumor immune responses
  2. Uyanik, Burhan; Goloudina, Anastasia R.; Akbarali, Aamir; Grigorash, Bogdan B.; Petukhov, Alexey V.; Singhal, Sunil; Eruslanov, Evgeniy; Chaloyard, Jeanne; Lagorgette, Lisa; Hadi, Tarik; Baidyuk, Ekaterina V.; Sakai, Hiroyasu; Tessarollo,Lino; Ryffel, Bernhard; Mazur, Sharlyn J.; Lirussi, Frederic; Garrido, Carmen; Appella, Ettore; Demidov, Oleg N.
  3. NATURE COMMUNICATIONS. 2021, Jun 15; 12(1):
  1. 4.   Tumour predisposition and cancer syndromes as models to study gene-environment interactions
  2. Carbone, Michele; Arron, Sarah T.; Beutler, Bruce; Bononi, Angela; Cavenee, Webster; Cleaver, James E.; Croce, Carlo M.; D'Andrea, Alan; Foulke, William D.; Gaudino, Giovanni; Groden, Joanna L.; Henske, Elizabeth P.; Hickson, Ian D.; Hwang, Paul M.; Kolodner, Richard D.; Mak, Tak W.; Malkin, David; Monnat, Raymond J. Jr Jr; Novelli, Flavia; Pass, Harvey; Petrini, John H.; Schmidt,Laura; Yang, Haining
  3. Nature reviews. Cancer. 2020, May 29;
  1. 5.   Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain
  2. Magnussen, Helge M.; Ahmed, Syed F.; Sibbet, Gary J.; Hristova, Ventzislava A.; Nomura, Koji; Hock, Andreas K.; Archibald, Lewis J.; Jamieson, Andrew G.; Fushman, David; Vousden, Karen H.; Weissman, Allan M.; Huang, Danny T.
  3. Nature communications. 2020, Apr 29; 11(1):
  1. 6.   Cancer-associated epithelial cell adhesion molecule (EpCAM; CD326) enables epidermal Langerhans cell motility and migration in vivo
  2. Gaiser, M. R.; Lammermann, T.; Feng, X.; Igyarto, B. Z.; Kaplan, D. H.; Tessarollo, L.; Germain, R. N.; Udey, M. C.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2012, Apr; 109(15): E889-E897.
  1. 7.   The Role of Estrogen Receptor alpha and beta in Regulating Vascular Smooth Muscle Cell Proliferation is Based on Sex
  2. Hogg, M. E.; Vavra, A. K.; Banerjee, M. N.; Martinez, J.; Jiang, Q.; Keefer, L. K.; Chambon, P.; Kibbe, M. R.
  3. Journal of Surgical Research. 2012, Mar; 173(1): E1-E10.
  1. 8.   Ablation of the transcriptional regulator Id1 enhances energy expenditure, increases insulin sensitivity, and protects against age and diet induced insulin resistance, and hepatosteatosis
  2. Satyanarayana, A.; Klarmann, K. D.; Gavrilova, O.; Keller, J. R.
  3. Faseb Journal. 2012, Jan; 26(1): 309-323.
  1. 9.   IKK alpha represses a network of inflammation and proliferation pathways and elevates c-Myc antagonists and differentiation in a dose-dependent manner in the skin
  2. Liu, B.; Willette-Brown, J.; Liu, S.; Chen, X.; Fischer, S. M.; Hu, Y.
  3. Cell Death and Differentiation. 2011, Dec; 18(12): 1854-1864.
  1. 10.   The p53 Inhibitor MDM2 Facilitates Sonic Hedgehog-Mediated Tumorigenesis and Influences Cerebellar Foliation
  2. Malek, R.; Matta, J.; Taylor, N.; Perry, M. E.; Mendrysa, S. M.
  3. Plos One. 2011, Mar; 6(3): 13.
  1. 11.   Evolution of a Major Drug Metabolizing Enzyme Defect in the Domestic Cat and Other Felidae: Phylogenetic Timing and the Role of Hypercarnivory
  2. Shrestha, B. S. B.; Reed, J. M.; Starks, P. T.; Kaufman, G. E.; Goldstone, J. V.; Roelke, M. E.; O'Brien, S. J.; Koepfli, K. P.; Frank, L. G.; Court, M. H.
  3. Plos One. 2011, Mar; 6(3): 11.
  1. 12.   Targeted JAM-C deletion in germ cells by Spo11-controlled Cre recombinase
  2. Pellegrini, M.; Claps, G.; Orlova, V. V.; Barrios, F.; Dolci, S.; Geremia, R.; Rossi, P.; Rossi, G.; Arnold, B.; Chavakis, T.; Feigenbaum, L.; Sharan, S. K.; Nussenzweig, A.
  3. Journal of Cell Science. 2011, Jan; 124(1): 91-99.
  1. 13.   Role of IKK alpha in skin squamous cell carcinomas
  2. Park, E. M.; Liu, B. G.; Xia, X. J.; Zhu, F.; Jami, W. B.; Hu, Y. L.
  3. Future Oncology. 2011, Jan; 7(1): 123-134.
  1. 14.   Fullerenol cytotoxicity in kidney cells is associated with cytoskeleton disruption, autophagic vacuole accumulation, and mitochondrial dysfunction
  2. Johnson-Lyles, D. N.; Peifley, K.; Lockett, S.; Neun, B. W.; Hansen, M.; Clogston, J.; Stern, S. T.; McNeil, S. E.
  3. Toxicology and Applied Pharmacology. 2010, Nov; 248(3): 249-258.
  1. 15.   Functional Coupling between the Extracellular Matrix and Nuclear Lamina by Wnt Signaling in Progeria
  2. Hernandez, L.; Roux, K. J.; Wong, E. S. M.; Mounkes, L. C.; Mutalif, R.; Navasankari, R.; Rai, B.; Cool, S.; Jeong, J. W.; Wang, H. H.; Lee, H. S.; Kozlov, S.; Grunert, M.; Keeble, T.; Jones, C. M.; Meta, M. D.,; Young, S. G.; Daar, I. O.; Burke, B.; Perantoni, A. O.; Stewart, C. L.
  3. Developmental Cell. 2010, Sep 14; 19(3): 413-425.
  1. 16.   Metformin Prevents Tobacco Carcinogen-Induced Lung Tumorigenesis
  2. Memmott, R. M.; Mercado, J. R.; Maier, C. R.; Kawabata, S.; Fox, S. D.; Dennis, P. A.
  3. Cancer Prevention Research. 2010, Sep; 3(9): 1066-1076.
  1. 17.   Reprogramming of T Cells to Natural Killer-Like Cells upon Bcl11b Deletion
  2. Li, P.; Burke, S.; Wang, J. X.; Chen, X. F.; Ortiz, M.; Lee, S. C.; Lu, D.; Campos, L.; Goulding, D.; Ng, B. L.; Dougan, G.; Huntly, B.; Gottgens, B.; Jenkins, N. A.; Copeland, N. G.; Colucci, F.; Liu, P. T.
  3. Science. 2010, Jul; 329(5987): 85-89.
  1. 18.   Schweinfurthin A Selectively Inhibits Proliferation and Rho Signaling in Glioma and Neurofibromatosis Type 1 Tumor Cells in a NF1-GRD-Dependent Manner
  2. Turbyville, T. J.; Gursel, D. B.; Tuskan, R. G.; Walrath, J. C.; Lipschultz, C. A.; Lockett, S. J.; Wiemer, D. F.; Beutler, J. A.; Reilly, K. M.
  3. Molecular Cancer Therapeutics. 2010, May; 9(5): 1234-1243.
  1. 19.   Interleukin-7 Regulates Bim Proapoptotic Activity in Peripheral T-Cell Survival
  2. Li, W. Q.; Guszczynski, T.; Hixon, J. A.; Durum, S. K.
  3. Molecular and Cellular Biology. 2010, Feb; 30(3): 590-600.
  1. 20.   Targeting of Bone-Derived Insulin-Like Growth Factor-II by a Human Neutralizing Antibody Suppresses the Growth of Prostate Cancer Cells in a Human Bone Environment
  2. Kimura, T.; Kuwata, T.; Ashimine, S.; Yamazaki, M.; Yamauchi, C.; Nagai, K.; Ikehara, A.; Feng, Y.; Dimitrov, D. S.; Saito, S.; Ochiai, A.
  3. Clinical Cancer Research. 2010, Jan; 16(1): 121-129.
  1. 21.   Urothelial Overexpression of Insulin-Like Growth Factor-1 Increases Susceptibility to p-Cresidine-Induced Bladder Carcinogenesis in Transgenic Mice
  2. Hursting, S. D.; Perkins, S. N.; Lavigne, J. A.; Beltran, L.; Haines, D. C.; Hill, H. L.; Alvord, W. G.; Barrett, J. C.; DiGiovanni, J.
  3. Molecular Carcinogenesis. 2009 48(8): 671-677.
  1. 22.   Antigen Presented by Tumors In vivo Determines the Nature of CD8(+) T-Cell Cytotoxicity
  2. Shanker, A.; Brooks, A. D.; Jacobsen, K. M.; Wine, J. W.; Wiltrout, R. H.; Yagita, H.; Sayers, T. J.
  3. Cancer Research. 2009 69(16): 6615-6623.
  1. 23.   Association of Single-Nucleotide Polymorphisms in JAK3, STAT4, and STAT6 With New Cardiovascular Events in Incident Dialysis Patients
  2. Sperati, C. J.; Parekh, R. S.; Berthier-Schaad, Y.; Jaar, B. G.; Plantinga, L.; Fink, N.; Powe, N. R.; Smith, M. W.; Coresh, J.; Kao, W.
  3. American Journal of Kidney Diseases. 2009 53(5): 845-855.
  1. 24.   Development of regulatory T cells requires IL-7R alpha stimulation by IL-7 or TSLP
  2. Mazzucchelli, R.; Hixon, J. A.; Spolski, R.; Chen, X.; Li, W. Q.; Hall, V. L.; Willette-Brown, J.; Hurwitz, A. A.; Leonard, W. J.; Durum, S. K.
  3. Blood. 2008, Oct 15; 112(8): 3283-3292.
  1. 25.   Genetic background and the dilemma of translating mouse studies to humans
  2. Rivera, J.; Tessarollo, L.
  3. Immunity. 2008 28(1): 1-4.
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