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  1. 1.   Leveraging long-acting IL-15 agonists for intratumoral delivery and enhanced antimetastatic activity
  2. Hangasky, John A; Fernández, Rocío Del Valle; Stellas,Dimitris; Hails, Guillermo; Karaliota,Sevasti; Ashley, Gary W; Felber,Barbara; Pavlakis,George; Santi, Daniel V
  3. Frontiers in Immunology. 2024, Nov 4; 15: 1458145.
  1. 2.   Tumor eradication by hetIL-15 locoregional therapy correlates with an induced intratumoral CD103intCD11b+ dendritic cell population
  2. Stellas, Dimitris; Karaliota,Sevasti; Stravokefalou, Vasiliki; Angel, Matthew; Nagy,Bethany; Goldfarbmuren,Kate; Bergamaschi, Cristina; Felber,Barbara; Pavlakis,George
  3. Cell Reports. 2023, May 12; 42(5): 112501.
  1. 3.   IL15 by Continuous Intravenous Infusion to Adult Patients with Solid Tumors in a Phase I Trial Induced Dramatic NK-Cell Subset Expansion
  2. Conlon, Kevin C.; Potter, E. Lake; Pittaluga, Stefania; Lee, Chyi-Chia Richard; Miljkovic, Milos D.; Fleisher, Thomas A.; Dubois, Sigrid; Bryant, Bonita R.; Petrus, Michael; Perera, Liyanage P.; Hsu, Jennifer; Figg, William D.; Peer, Cody J.; Shih, Joanna H.; Yovandich,Jason; Creekmore,Stephen; Roederer, Mario; Waldmann, Thomas A.
  3. CLINICAL CANCER RESEARCH. 2019, Aug 15; 25(16): 4945-4954.
  1. 4.   IL-2 and IL-15 blockade by BNZ-1, an inhibitor of selective gamma-chain cytokines, decreases leukemic T-cell viability
  2. Wang, T. Tiffany; Yang, Jun; Zhang, Yong; Zhang,Meili; Dubois, Sigrid; Conlon, Kevin C.; Tagaya, Yutaka; Hamele, Cait E.; Dighe, Shubha; Olson, Thomas L.; Feith, David J.; Azimi, Nazli; Waldmann, Thomas A.; Loughran, Thomas P.
  3. Leukemia. 2019, May; 33(5): 1243-1255.
  1. 5.   IL-15 enhanced antibody-dependent cellular cytotoxicity mediated by NK cells and macrophages
  2. Zhang,Meili; Wen, Bernard; Anton, Olga M.; Yao, Zhengsheng; Dubois, Sigrid; Ju, Wei; Sato, Noriko; DiLillo, David J.; Bamford, Richard N.; Ravetch, Jeffrey; Waldmann, Thomas A.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2018, NOV 13; 115(46): E10915-E10924.
  1. 6.   Scalable, cGMP-compatible purification of extracellular vesicles carrying bioactive human heterodimeric IL-15/lactadherin complexes
  2. Watson, Dennis; Yung, Bryant C; Bergamaschi, Cristina; Chowdhury, Bhabadeb; Bear, Jenifer; Stellas, Dimitrios; Morales-Kastresana, Aizea; Jones, Jennifer C; Felber, Barbara; Chen, Xiaoyuan; Pavlakis, George
  3. Journal of Extracellular Vesicles. 2018, Feb 28; 7(1): 1442088.
  1. 7.   Purification of inclusion bodies using PEG precipitation under denaturing conditions to produce recombinant therapeutic proteins from Escherichia coli
  2. Chen, Huanhuan; Li, Ninghuan; Xie, Yueqing; Jiang, Hua; Yang, Xiaoyi; Cagliero, Cedric; Shi, Siwei; Zhu, Chencen; Luo, Han; Chen, Junsheng; Zhang, Lei; Zhao, Menglin; Feng, Lei; Lu, Huili; Zhu, Jianwei
  3. Applied Microbiology and Biotechnology. 2017, Jul; 101(13): 5267-5278.
  1. 8.   Configuration-dependent Presentation of Multivalent IL-15:IL-15Ralpha Enhances the Antigen-specific T Cell Response and Anti-tumor Immunity
  2. Hong, E.; Usiskin, I. M.; Bergamaschi, C.; Hanlon, D. J.; Edelson, R. L.; Justesen, S.; Pavlakis, G. N.; Flavell, R. A.; Fahmy, T. M.
  3. The Journal of biological chemistry. 2016, 22-Apr; 291(17): 8931-50.
  1. 9.   Characterization of Recombinant Human IL-15 Deamidation and Its Practical Elimination through Substitution of Asparagine 77
  2. Nellis, D. F.; Michiel, D. F.; Jiang, M. S.; Esposito, D.; Davis, R.; Jiang, H. G.; Korrell, A.; Knapp, G. C.; Lucernoni, L. E.; Nelson, R. E.; Pritt, E. M.; Procter, L. V.; Rogers, M.; Sumpter, T. L.; Vyas, V. V.; Waybright, T. J.; Yang, X. Y.; Zheng, A. M.; Yovandich, J. L.; Gilly, J. A.; Mitra, G.; Zhu, J. W.
  3. Pharmaceutical Research. 2012, Mar; 29(3): 722-738.
  1. 10.   IL-15 administered by continuous infusion to rhesus macaques induces massive expansion of CD8(+) T effector memory population in peripheral blood
  2. Sneller, M. C.; Kopp, W. C.; Engelke, K. J.; Yovandich, J. L.; Creekmore, S. P.; Waldmann, T. A.; Lane, H. C.
  3. Blood. 2011, Dec; 118(26): 6845-6848.
  1. 11.   Hydrodynamic Delivery of Human IL-15 cDNA Increases Murine Natural Killer Cell Recovery after Syngeneic Bone Marrow Transplantation
  2. Barao, I.; Alvarez, M.; Redelman, D.; Weiss, J. M.; Ortaldo, J. R.; Wiltrout, R. H.; Murphy, W. J.
  3. Biology of Blood and Marrow Transplantation. 2011, Dec; 17(12): 1754-1764.
  1. 12.   IL-15:IL-15 receptor alpha superagonist complex: High-level co-expression in recombinant mammalian cells, purification and characterization
  2. Han, K. P.; Zhu, X. Y.; Liu, B.; Jeng, E.; Kong, L.; Yovandich, J. L.; Vyas, V. V.; Marcus, W. D.; Chavaillaz, P. A.; Romero, C. A.; Rhode, P. R.; Wong, H. C.
  3. Cytokine. 2011, Dec; 56(3): 804-810.
  1. 13.   Safety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in rhesus macaques
  2. Waldmann, T. A.; Lugli, E.; Roederer, M.; Perera, L. P.; Smedley, J. V.; Macallister, R. P.; Goldman, C. K.; Bryant, B. R.; Decker, J. M.; Fleisher, T. A.; Lane, H. C.; Sneller, M. C.; Kurlander, R. J.; Kleiner, D. E.; Pletcher, J. M.; Figg, W. D.; Yovandich, J. L.; Creekmore, S. P.
  3. Blood. 2011, May; 117(18): 4787-4795.
  1. 14.   The transcription factor c-Myc enhances KIR gene transcription through direct binding to an upstream distal promoter element
  2. Cichocki, F.; Hanson, R. J.; Lenvik, T.; Pitt, M.; McCullar, V.; Li, H.; Anderson, S. K.; Miller, J. S.
  3. Blood. 2009 113(14): 3245-3253.
  1. 15.   Expression of Interleukin-15 and Its Receptor on the Surface of Stimulated Human Umbilical Vein Endothelial Cells
  2. Liu, X. P.; Zuo, Y. M.; Zhang, W. N.; Yang, D. G.; Xiong, C. Y.; Zhang, X. Z.
  3. Journal of Huazhong University of Science and Technology-medical Sciences. 2009 29(5): 527-534.
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