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  1. 1.   Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR
  2. Zong, Dali; Koussa, Natasha C; Cornwell, James A; Pankajam, Ajith V; Kruhlak, Michael J; Wong, Nancy; Chari,Raj; Cappell, Steven D; Nussenzweig, André
  3. Genes & Development. 2023, Nov 06; 37(19-20): 913-928.
  1. 2.   Genomic and evolutionary classification of lung cancer in never smokers
  2. Zhang, Tongwu; Joubert, Philippe; Ansari-Pour, Naser; Zhao, Wei; Hoang, Phuc H.; Lokanga, Rachel; Moye, Aaron L.; Rosenbaum, Jennifer; Gonzalez-Perez, Abel; Martinez-Jimenez, Francisco; Castro, Andrea; Muscarella, Lucia Anna; Hofman, Paul; Consonni, Dario; Pesatori, Angela C.; Kebede, Michael; Li, Mengying; Rothberg, Bonnie E. Gould; Peneva, Iliana; Schabath, Matthew B.; Poeta, Maria Luana; Costantini, Manuela; Hirsch, Daniela; Heselmeyer-Haddad, Kerstin; Hutchinson,Amy; Olanich, Mary; Lawrence,Scott; Lenz,Petra; Duggan, Maire; Bhawsar, Praphulla M. S.; Sang, Jian; Kim, Jung; Mendoza, Laura; Saini, Natalie; Klimczak, Leszek J.; Islam, S. M. Ashiqul; Otlu, Burcak; Khandekar, Azhar; Cole,Nathan; Stewart, Douglas R.; Choi, Jiyeon; Brown, Kevin M.; Caporaso, Neil E.; Wilson, Samuel H.; Pommier, Yves; Lan, Qing; Rothman, Nathaniel; Almeida, Jonas S.; Carter, Hannah; Ried, Thomas; Kim, Carla F.; Lopez-Bigas, Nuria; Garcia-Closas, Montserrat; Shi, Jianxin; Bosse, Yohan; Zhu, Bin; Gordenin, Dmitry A.; Alexandrov, Ludmil B.; Chanock, Stephen J.; Wedge, David C.; Landi, Maria Teresa
  3. Nature genetics. 2021, Sep; 53(9): 1348-1359.
  1. 3.   Sensitivity of Oncogenic KRAS-Expressing Cells to CDK9 Inhibition
  2. Lai, Lick Pui; Brel, Viviane; Sharma, Kanika; Frappier, Julia; Le-Henanf, Nadia; Vivet, Bertrand; Muzet, Nicolas; Schell, Emilie; Morales, Renaud; Rooney, Eamonn; Basse, Nicolas; Yi,Ming; Lacroix, Frederic; Holderfield, Matthew; Englaro, Walter; Marcireau, Christophe; Debussche, Laurent; Nissley,Dwight; McCormick, Frank
  3. SLAS DISCOVERY. 2021, Apr 24; 26(7, SI): 922-932.
  1. 4.   Molecular Features of Cancers Exhibiting Exceptional Responses to Treatment
  2. Wheeler, David A; Takebe, Naoko; Hinoue, Toshinori; Hoadley, Katherine A; Cardenas, Maria F; Hamilton, Alina M; Laird, Peter W; Wang, Linghua; Johnson, Adrienne; Dewal, Ninad; Miller, Vincent; Piñeyro, David; Castro de Moura, Manuel; Esteller, Manel; Shen, Hui; Zenklusen, Jean Claude; Tarnuzzer, Roy; McShane, Lisa M; Tricoli, James V; Williams, Paul M; Lubensky, Irina; O'Sullivan-Coyne, Geraldine; Kohn, Elise C; Little, Richard F; White, Jeffrey; Malik, Shakun; Harris, Lyndsay; Weil, Carol; Chen, Alice P; Karlovich,Chris; Rodgers, Brian; Shankar, Lalitha; Jacobs, Paula; Nolan, Tracy; Hu, Jianhong; Muzny, Donna M; Doddapaneni, Harshavardhan; Korchina, Viktoriya; Gastier-Foster, Julie; Bowen, Jay; Leraas, Kristen; Edmondson,Elijah; Doroshow, James H; Conley, Barbara A; Ivy, S Percy; Staudt, Louis M
  3. Cancer Cell. 2021, Jan 11; 39(1): 38-53.e7.
  1. 5.   Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain
  2. Magnussen, Helge M.; Ahmed, Syed F.; Sibbet, Gary J.; Hristova, Ventzislava A.; Nomura, Koji; Hock, Andreas K.; Archibald, Lewis J.; Jamieson, Andrew G.; Fushman, David; Vousden, Karen H.; Weissman, Allan M.; Huang, Danny T.
  3. Nature communications. 2020, Apr 29; 11(1):
  1. 6.   RAD52 S346X Variant Reduces Breast Cancer Risk in BRCA2 Mutation Carriers
  2. Biswas,Kajal; Sharan,Shyam
  3. Molecular oncology. 2020, Apr 07;
  1. 7.   SL-BioDP: Multi-Cancer Interactive Tool for Prediction of Synthetic Lethality and Response to Cancer Treatment
  2. Deng,Xiang; Das, Shaoli; Valdez,Kristin; Camphausen, Kevin; Shankavaram, Uma
  3. Cancers. 2019, Nov; 11(11): pii: E1682.
  1. 8.   BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation
  2. Zong, Dali; Adam, Salome; Wang, Yifan; Sasanuma, Hiroyuki; Callen, Elsa; Murga, Matilde; Day, Amanda; Kruhlak, Michael J.; Wong, Nancy; Munro, Meagan; Chaudhuri, Arnab Ray; Karim,Baktiar; Xia, Bing; Takeda, Shunichi; Johnson, Neil; Durocher, Daniel; Nussenzweig, Andre
  3. Molecular cell. 2019, MAR 21; 73(6): 1267-+.
  1. 9.   Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration
  2. Diril, M. K.; Ratnacaram, C. K.; Padmakumar, V. C.; Du, T. H.; Wasser, M.; Coppola, V.; Tessarollo, L.; Kaldis, P.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2012, Mar; 109(10): 3826-3831.
  1. 10.   Advances in using PARP inhibitors to treat cancer
  2. Kummar, S.; Chen, A.; Parchment, R. E.; Kinders, R. J.; Ji, J.; Tomaszewski, J. E.; Doroshow, J. H.
  3. Bmc Medicine. 2012, Mar; 10
  1. 11.   The p53 Inhibitor MDM2 Facilitates Sonic Hedgehog-Mediated Tumorigenesis and Influences Cerebellar Foliation
  2. Malek, R.; Matta, J.; Taylor, N.; Perry, M. E.; Mendrysa, S. M.
  3. Plos One. 2011, Mar; 6(3): 13.
  1. 12.   Rb/Cdk2/Cdk4 triple mutant mice elicit an alternative mechanism for regulation of the G(1)/S transition
  2. Li, W.; Kotoshiba, S.; Berthet, C.; Hilton, M. B.; Kaldis, P.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2009 106(2): 486-491.
  1. 13.   Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms
  2. Satyanarayana, A.; Kaldis, P.
  3. Oncogene. 2009 28(33): 2925-2939.
  1. 14.   Discovery of new pyridoacridine alkaloids from Lissoclinum cf. badium that inhibit the ubiquitin ligase activity of Hdm2 and stabilize p53
  2. Clement, J. A.; Kitagaki, J.; Yang, Y.; Saucedo, C. J.; O'Keefe, B. R.; Weissman, A. M.; Mckee, T. C.; McMahon, J. B.
  3. Bioorganic & Medicinal Chemistry. 2008 16(23): 10022-10028.
  1. 15.   Hypoxia-inducible factor-1 target genes as indicators of tumor vessel response to vascular endothelial growth factor inhibition
  2. Dang, D. T.; Chun, S. Y.; Burkitt, K.; Abe, M.; Chen, S.; Havre, P.; Mabjeesh, N. J.; Heath, E. I.; Vogelzang, N. J.; Cruz-Correa, M.; Blayney, D. W.; Ensminger, W. D.; Croix, B. S.; Dang, N. H.; Dang, L. H.
  3. Cancer Research. 2008 68(6): 1872-1880.
  1. 16.   Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2
  2. Kitagaki, J.; Agama, K. K.; Pommier, Y.; Yang, Y. L.; Weissman, A. M.
  3. Molecular Cancer Therapeutics. 2008 7(8): 2445-2454.
  1. 17.   Dll4 activation of Notch signaling reduces tumor vascularity and inhibits tumor growth
  2. Segarra, M.; Williams, C. K.; Sierra, M. D.; Bernardo, M.; McCormick, P. J.; Maric, D.; Regino, C.; Choyke, P.; Tosato, G.
  3. Blood. 2008 112(5): 1904-1911.
  1. 18.   Inactivation of the mouse Magel2 gene results in growth abnormalities similar to Prader-Willi syndrome
  2. Bischof, J. M.; Stewart, C. L.; Wevrick, R.
  3. Human Molecular Genetics. 2007, Nov; 16(22): 2713-2719.
  1. 19.   The imprinted gene Magel2 regulates normal circadian output
  2. Kozlov, S. V.; Bogenpohl, J. W.; Howell, M. P.; Wevrick, R.; Panda, S.; Hogenesch, J. B.; Muglia, L. J.; Van Gelder, R. N.; Herzog, E. D.; Stewart, C. L.
  3. Nature Genetics. 2007, Oct; 39(10): 1266-1272.
  1. 20.   Vascular defects and liver damage by the acute inactivation of the VHL gene during mouse embryogenesis
  2. Hong, S. B.; Furihata, M.; Baba, M.; Zbar, B.; Schmidt, L. S.
  3. Laboratory Investigation. 2006, Jul; 86(7): 664-675.
  1. 21.   Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation
  2. Berthet, C.; Klarmann, K. D.; Hilton, M. B.; Suh, H. C.; Keller, J. R.; Kiyokawa, H.; Kaldis, P.
  3. Developmental Cell. 2006, MAY; 10(5): 563-573.
  1. 22.   Tumor suppression and normal aging in mice with constitutively high p53 activity
  2. Mendrysa, S. M.; O'Leary, K. A.; McElwee, M. K.; Michalowski, J.; Eisenman, R. N.; Powell, D. A.; Perry, M. E.
  3. Genes & Development. 2006, JAN 1; 20(1): 16-21.
  1. 23.   FGFR1 function at the earliest stages of mouse limb development plays an indispensable role in subsequent autopod morphogenesis
  2. Li, C. L.; Xu, X. L.; Nelson, D. K.; Williams, T.; Kuehn, M. R.; Deng, C. X.
  3. Development. 2005, NOV; 132(21): 4755-4764.
  1. 24.   Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models
  2. Difilippantonio, S.; Celeste, A.; Fernandez-Capetillo, O.; Chen, H. T.; San Martin, B. R.; Van Laethem, F.; Yang, Y. P.; Petukhova, G. V.; Eckhaus, M.; Feigenbaum, L.; Manova, K.; Kruhlak, M.; Camerini-Otero, R. D.; Sharan, S.; Nussenzweig, M.; Nussenzweig, A.
  3. Nature Cell Biology. 2005, JUL; 7(7): 675-U56.
  1. 25.   Conditional alleles for activation and inactivation of the mouse Rx homeobox gene
  2. Voronina, V. A.; Kozlov, S.; Mathers, P. H.; Lewandoski, M.
  3. Genesis. 2005, APR; 41(4): 160-164.
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