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  1. 1.   Design, Synthesis, and Biological Evaluation of 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines as Microtubule Targeting Agents
  2. Islam, Farhana; Doshi, Arpit; Robles, Andrew J; Quadery, Tasdique M; Zhang, Xin; Zhou, Xilin; Hamel, Ernest; Mooberry, Susan L; Gangjee, Aleem
  3. Molecules . 2022, Jan 05; 27(1):
  1. 2.   Concise synthesis and biological evaluation of 2-Aryl-3-Anilinobenzo[b] thiophene derivatives as potent apoptosis-inducing agents
  2. Romagnoli, Romeo; Preti, Delia; Hamel,Ernest; Bortolozzi, Roberta; Viola, Giampietro; Brancale, Andrea; Ferla, Salvatore; Morciano, Giampaolo; Pinton, Paolo
  3. Bioorganic chemistry. 2021, Jul; 112
  1. 3.   A brain-penetrant microtubule-targeting agent that disrupts hallmarks of glioma tumorigenesis
  2. Horne, Eric A; Diaz, Philippe; Cimino, Patrick J; Jung, Erik; Xu, Cong; Hamel,Ernest; Wagenbach, Michael; Kumasaka, Debra; Wageling, Nicholas B; Azorín, Daniel D; Winkler, Frank; Wordeman, Linda G; Holland, Eric C; Stella, Nephi
  3. Neuro-oncology advances. 2021, Jan-Dec; 3(1): vdaa165.
  1. 4.   Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors
  2. Oliva, Paola; Romagnoli, Romeo; Manfredini, Stefano; Brancale, Andrea; Ferla, Salvatore; Hamel,Ernest; Ronca, Roberto; Maccarinelli, Federica; Giacomini, Arianna; Rruga, Fatlum; Mariotto, Elena; Viola, Giampietro; Bortolozzi, Roberta
  3. European journal of medicinal chemistry. 2020, AUG 15; 200: 112448.
  1. 5.   Synthesis and Biological Evaluation of 2-Substituted Benzyl-/Phenylethylamino-4-amino-5-aroylthiazoles as Apoptosis-Inducing Anticancer Agents
  2. Oliva, Paola; Onnis, Valentina; Balboni, Elisa; Hamel,Ernest; Estévez-Sarmiento, Francisco; Quintana, José; Estévez, Francisco; Brancale, Andrea; Ferla, Salvatore; Manfredini, Stefano; Romagnoli, Romeo
  3. Molecules (Basel, Switzerland). 2020, May 06; 25(9):
  1. 6.   Synthesis and Biological Evaluation of New Antitubulin Agents Containing 2-(3',4',5'-trimethoxyanilino)-3,6-disubstituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine Scaffold
  2. Romagnoli, Romeo; Prencipe, Filippo; Oliva, Paola; Cacciari, Barbara; Balzarini, Jan; Liekens, Sandra; Hamel,Ernest; Brancale, Andrea; Ferla, Salvatore; Manfredini, Stefano; Zurlo, Matteo; Finotti, Alessia; Gambari, Roberto
  3. Molecules (Basel, Switzerland). 2020, Apr 07; 25(7): pii : molecules25071690.
  1. 7.   Design, synthesis and biological evaluation of 2-alkoxycarbonyl-3-anilinoindoles as a new class of potent inhibitors of tubulin polymerization
  2. Romagnoli, Romeo; Prencipe, Filippo; Oliva, Paola; Kimatrai Salvador, Maria; Brancale, Andrea; Ferla, Salvatore; Hamel,Ernest; Viola, Giampietro; Bortolozzi, Roberta; Persoons, Leentje; Balzarini, Jan; Liekens, Sandra; Schols, Dominique
  3. Bioorganic chemistry. 2020, APR; 97: 103665.
  1. 8.   Interaction of diazonamide a with tubulin
  2. Bai,Ruoli; Cruz-Monserrate, Zobeida; Fenical, William; Pettit, George R; Hamel,Ernest
  3. Archives of biochemistry and biophysics. 2020, FEB 15; 680: 108217.
  1. 9.   Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors
  2. Romagnoli, Romeo; Oliva, Paola; Salvador, Maria Kimatrai; Camacho, Maria Encarnacion; Padroni, Chiara; Brancale, Andrea; Ferla, Salvatore; Hamel,Ernest; Ronca, Roberto; Grillo, Elisabetta; Bortolozzi, Roberta; Rruga, Fatlum; Mariotto, Elena; Viola, Giampietro
  3. European journal of medicinal chemistry. 2019, NOV 1; 181: 111577.
  1. 10.   Modified carbazoles destabilize microtubules and kill glioblastoma multiform cells
  2. Diaz, Philippe; Horne, Eric; Xu, Cong; Hamel, Ernest; Wagenbach, Michael; Petrov, Ravil R; Uhlenbruck, Benjamin; Haas, Brian; Hothi, Parvinder; Wordeman, Linda; Gussio, Rick; Stella, Nephi
  3. European journal of medicinal chemistry. 2018, Nov 5; 159: 74-89.
  1. 11.   Targeting tubulin polymerization by novel 7-aryl-pyrroloquinolinones: Synthesis, biological activity and SARs
  2. Bortolozzi, Roberta; Mattiuzzo, Elena; Dal Pra, Matteo; Sturlese, Mattia; Moro, Stefano; Hamel, Ernest; Carta, Davide; Viola, Giampietro; Ferlin, Maria Grazia
  3. European journal of medicinal chemistry. 2018, Jan 1; 143: 244-258.
  1. 12.   Targeting tubulin polymerization by novel 7-aryl-pyrroloquinolinones: Synthesis, biological activity and SARs
  2. Bortolozzi, Roberta; Mattiuzzo, Elena; Dal Pra, Matteo; Sturlese, Mattia; Moro, Stefano; Hamel, Ernest; Carta, Davide; Viola, Giampietro; Ferlin, Maria Grazia
  3. European Journal of Medicinal Chemistry. 2018, Jan 01; 143: 244-258.
  1. 13.   Design, synthesis, and structure-activity relationships of pyrimido[4,5-b]indole-4-amines as microtubule depolymerizing agents that are effective against multidrug resistant cells
  2. Devambatla, Ravi Kumar Vyas; Li, Wei; Zaware, Nilesh; Choudhary, Shruti; Hamel, Ernest; Mooberry, Susan L; Gangjee, Aleem
  3. Bioorganic & Medicinal Chemistry Letters. 2017, Aug 01; 27(15): 3423-3430.
  1. 14.   Synthesis, structure-activity relationships and biological evaluation of 7-phenyl-pyrroloquinolinone 3-amide derivatives as potent antimitotic agents
  2. Carta, D.; Bortolozzi, R.; Sturlese, M.; Salmaso, V.; Hamel, Ernest; Basso, G.; Calderan, L.; Quintieri, L.; Moro, S.; Viola, G.; Ferlin, M. G.
  3. European Journal of Medicinal Chemistry. 2017, Feb 15; 127: 643-660.
  1. 15.   MDM1 is a microtubule-binding protein that negatively regulates centriole duplication
  2. Van de Mark, D.; Kong, D.; Loncarek, J.; Stearns, T.
  3. Molecular Biology of the Cell. 2015, 1-Nov; 26(21): 3788-802.
  1. 16.   MG-2477, a new tubulin inhibitor, induces autophagy through inhibition of the Akt/mTOR pathway and delayed apoptosis in A549 cells
  2. Viola, G.; Bortolozzi, R.; Hamel, E.; Moro, S.; Brun, P.; Castagliuolo, I.; Ferlin, M. G.; Basso, G.
  3. Biochemical Pharmacology. 2012, Jan; 83(1): 16-26.
  1. 17.   One-pot synthesis and biological evaluation of 2-pyrrolidinyl-4-amino-5-(3 ',4 ',5 '-trimethoxybenzoyl)thiazole: A unique, highly active antimicrotubule agent
  2. Romagnoli, R.; Baraldi, P. G.; Cara, C. L.; Salvador, M. K.; Bortolozzi, R.; Basso, G.; Viola, G.; Balzarini, J.; Brancale, A.; Fu, X. H.; Li, J.; Zhang, S. Z.; Hamel, E.
  3. European Journal of Medicinal Chemistry. 2011, Dec; 46(12): 6015-6024.
  1. 18.   Combinatorial Tau Pseudophosphorylation MARKEDLY DIFFERENT REGULATORY EFFECTS ON MICROTUBULE ASSEMBLY AND DYNAMIC INSTABILITY THAN THE SUM OF THE INDIVIDUAL PARTS
  2. Kiris, E.; Ventimiglia, D.; Sargin, M. E.; Gaylord, M. R.; Altinok, A.; Rose, K.; Manjunath, B. S.; Jordan, M. A.; Wilson, L.; Feinstein, S. C.
  3. Journal of Biological Chemistry. 2011, Apr; 286(16): 14257-14270.
  1. 19.   Synthesis and biological evaluation of 2-(3 ',4 ',5 '-trimethoxybenzoyl)-3-aryl/arylaminobenzo[b]thiophene derivatives as a novel class of antiproliferative agents
  2. Romagnoli, R.; Baraldi, P. G.; Cara, C. L.; Hamel, E.; Basso, G.; Bortolozzi, R.; Viola, G.
  3. European Journal of Medicinal Chemistry. 2010, Dec; 45(12): 5781-5791.
  1. 20.   Substituted 2-(3 ',4 ',5 '-trimethoxybenzoyl)-benzo[b]thiophene derivatives as potent tubulin polymerization inhibitors
  2. Romagnoli, R.; Baraldi, P. G.; Carrion, M. D.; Cruz-Lopez, O.; Tolomeo, M.; Grimaudo, S.; Di Cristina, A.; Pipitone, M. R.; Balzarini, J.; Brancale, A.; Hamel, E.
  3. Bioorganic & Medicinal Chemistry. 2010, Jul; 18(14): 5114-5122.
  1. 21.   Quantitative Analysis of MAP-Mediated Regulation of Microtubule Dynamic Instability In Vitro-Focus on Tau
  2. Kiris, E.; Ventimiglia, D.; Feinstein, S. C.
  3. Methods in cell biology. 2010; 95 : 481-503.
  1. 22.   Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization
  2. Roux, K. J.; Crisp, M. L.; Liu, Q.; Kim, D.; Kozlov, S.; Stewart, C. L.; Burke, B.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2009 106(7): 2194-2199.
  1. 23.   Novel fold of VirA, a type III secretion system effector protein from Shigella flexneri
  2. Davis, J.; Wang, J. W.; Tropea, J. E.; Zhang, D.; Dauter, Z.; Waugh, D. S.; Wlodawer, A.
  3. Protein Science. 2008 17(12): 2167-2173.
  1. 24.   Synthesis and biological evaluation of 2-amino-3-(3 ',4 ',5 '-trimethoxybenzoyl)-6-substituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridi ne derivatives as antimitotic agents and inhibitors of tubulin polymerization
  2. Romagnoli, R.; Baraldi, P. G.; Carrion, M. D.; Cruz-Lopez, O.; Cara, C. L.; Tolomeo, M.; Grimaudo, S.; Di Cristina, A.; Pipitone, M. R.; Balzarini, J.; Kandil, S.; Brancale, A.; Sarkar, T.; Hamel, E.
  3. Bioorganic & Medicinal Chemistry Letters. 2008 18(18): 5041-5045.
  1. 25.   EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1
  2. Thomas, S. L.; Zhong, D. S.; Zhou, W.; Malik, S.; Liotta, D.; Snyder, J. P.; Hamel, E.; Giannakakou, P.
  3. Cell Cycle. 2008 7(15): 2409-2417.
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