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  1. 1.   Design, Synthesis and Biological Evaluation of 2-Phenyl Indole Analogues of OXi8006 as Colchicine Site Inhibitors of Tubulin Polymerization and Vascular Disrupting Agents
  2. Vairin, Rebecca; Tamminga, Caleb; Shi, Zhe; Borchardt, Christian; Jambulapati, Jayaram; Bai, Ruoli; Wanniarachchi, Hashini; Bueno, Lorena; Hamel,Ernest; Mason, Ralph P; Trawick, Mary Lynn; Pinney, Kevin G
  3. Bioorganic & Medicinal Chemistry. 2024, Nov 07; 118: 117981.
  1. 2.   Simple monocyclic pyrimidine analogs as microtubule targeting agents binding to the colchicine site
  2. Choudhary, Shruti; Kaku, Krishna; Robles, Andrew J; Hamel,Ernest; Mooberry, Susan L; Gangjee, Aleem
  3. Bioorganic & Medicinal Chemistry. 2023, Feb 24; 82: 117217.
  1. 3.   Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas
  2. Barreca, Marilia; Spanò, Virginia; Rocca, Roberta; Bivacqua, Roberta; Abel, Anne-Catherine; Maruca, Annalisa; Montalbano, Alessandra; Raimondi, Maria Valeria; Tarantelli, Chiara; Gaudio, Eugenio; Cascione, Luciano; Rinaldi, Andrea; Bai,Ruoli; Steinmetz, Michel O; Prota, Andrea E; Alcaro, Stefano; Hamel, Ernest; Bertoni, Francesco; Barraja, Paola
  3. European Journal of Medicinal Chemistry. 2022, Sep 08; 243: 114744.
  1. 4.   Design, Synthesis and Biological Investigation of 2-Anilino Triazolopyrimidines as Tubulin Polymerization Inhibitors with Anticancer Activities
  2. Romagnoli, Romeo; Oliva, Paola; Prencipe, Filippo; Manfredini, Stefano; Budassi, Federica; Brancale, Andrea; Ferla, Salvatore; Hamel,Ernest; Corallo, Diana; Aveic, Sanja; Manfreda, Lorenzo; Mariotto, Elena; Bortolozzi, Roberta; Viola, Giampietro
  3. Pharmaceuticals (Basel, Switzerland). 2022, Aug 21; 15(8):
  1. 5.   Design, Synthesis, and Biological Evaluation of 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines as Microtubule Targeting Agents
  2. Islam, Farhana; Doshi, Arpit; Robles, Andrew J; Quadery, Tasdique M; Zhang, Xin; Zhou, Xilin; Hamel, Ernest; Mooberry, Susan L; Gangjee, Aleem
  3. Molecules . 2022, Jan 05; 27(1):
  1. 6.   Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure-activity relationship, in vitro and in vivo evaluation as antitumor agents
  2. Islam, Farhana; Quadery, Tasdique M.; Bai,Ruoli; Luckett-Chastain, Lerin R.; Hamel,Ernest; Ihnat, Michael A.; Gangjee, Aleem
  3. Bioorganic & Medicinal Chemistry Letters. 2021, Jun 1; 41
  1. 7.   Pyrrolo[2 ',3 ':3,4]cyclohepta[1,2-d][1,2]oxazoles, a New Class of Antimitotic Agents Active against Multiple Malignant Cell Types
  2. Spano, Virginia; Rocca, Roberta; Barreca, Marilia; Giallombardo, Daniele; Montalbano, Alessandra; Carbone, Anna; Raimondi, Maria Valeria; Gaudio, Eugenio; Bortolozzi, Roberta; Bai,Ruoli; Tassone, Pierfrancesco; Alcaro, Stefano; Hamel,Ernest; Viola, Giampietro; Bertoni, Francesco; Barraja, Paola
  3. JOURNAL OF MEDICINAL CHEMISTRY. 2020, OCT 22; 63(20): 12023-12042.
  1. 8.   Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors
  2. Oliva, Paola; Romagnoli, Romeo; Manfredini, Stefano; Brancale, Andrea; Ferla, Salvatore; Hamel,Ernest; Ronca, Roberto; Maccarinelli, Federica; Giacomini, Arianna; Rruga, Fatlum; Mariotto, Elena; Viola, Giampietro; Bortolozzi, Roberta
  3. European journal of medicinal chemistry. 2020, AUG 15; 200: 112448.
  1. 9.   Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2-d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors
  2. Romagnoli, Romeo; Prencipe, Filippo; Oliva, Paola; Baraldi, Stefania; Baraldi, Pier Giovanni; Schiaffino Ortega, Santiago; Chayah, Mariem; Kimatrai Salvador, Maria; Carlota Lopez-Cara, Luisa; Brancale, Andrea; Ferla, Salvatore; Hamel,Ernest; Ronca, Roberto; Bortolozzi, Roberta; Mariotto, Elena; Mattiuzzo, Elena; Viola, Giampietro
  3. JOURNAL OF MEDICINAL CHEMISTRY. 2019, Feb 14; 62(3): 1274-1290.
  1. 10.   Tetrahydroisoquinoline Sulfamates as Potent Microtubule Disruptors: Synthesis, Antiproliferative and Antitubulin Activity of Dichlorobenzyl-Based Derivatives, and a Tubulin Cocrystal Structure
  2. Dohle, Wolfgang; Prota, Andrea E.; Menchon, Gregory; Hamel,Ernest; Steinmetz, Michel O.; Potter, Barry V. L.
  3. ACS omega. 2019, Jan 31; 4(1): 755-764.
  1. 11.   Modified carbazoles destabilize microtubules and kill glioblastoma multiform cells
  2. Diaz, Philippe; Horne, Eric; Xu, Cong; Hamel, Ernest; Wagenbach, Michael; Petrov, Ravil R; Uhlenbruck, Benjamin; Haas, Brian; Hothi, Parvinder; Wordeman, Linda; Gussio, Rick; Stella, Nephi
  3. European journal of medicinal chemistry. 2018, Nov 5; 159: 74-89.
  1. 12.   Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure
  2. Dohle, Wolfgang; Jourdan, Fabrice L.; Menchon, Gregory; Prota, Andrea E.; Foster, Paul A.; Mannion, Pascoe; Hamel, Ernest; Thomas, Mark P.; Kasprzyk, Philip G.; Ferrandis, Eric; Steinmetz, Michel O.; Leese, Mathew P.; Potter, Barry V. L.
  3. JOURNAL OF MEDICINAL CHEMISTRY. 2018, Feb 8; 61(3): 1031-1044.
  1. 13.   2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition
  2. Romagnoli, Romeo; Kimatrai Salvador, Maria; Schiaffino Ortega, Santiago; Baraldi, Pier Giovanni; Oliva, Paola; Baraldi, Stefania; Lopez-Cara, Luisa Carlota; Brancale, Andrea; Ferla, Salvatore; Hamel, Ernest; Balzarini, Jan; Liekens, Sandra; Mattiuzzo, Elena; Basso, Giuseppe; Viola, Giampietro
  3. European Journal of Medicinal Chemistry. 2018, Jan 1; 143: 683-698.
  1. 14.   Synthesis and Evaluation of 1,5-Disubstituted Tetrazoles as Rigid Analogues of Combretastatin A-4 with Potent Antiproliferative and Antitumor Activity
  2. Romagnoli, R.; Baraldi, P. G.; Salvador, M. K.; Preti, D.; Tabrizi, M. A.; Brancale, A.; Fu, X. H.; Li, J.; Zhang, S. Z.; Hamel, E.; Bortolozzi, R.; Basso, G.; Viola, G.
  3. Journal of Medicinal Chemistry. 2012, Jan; 55(1): 475-488.
  1. 15.   One-pot synthesis and biological evaluation of 2-pyrrolidinyl-4-amino-5-(3 ',4 ',5 '-trimethoxybenzoyl)thiazole: A unique, highly active antimicrotubule agent
  2. Romagnoli, R.; Baraldi, P. G.; Cara, C. L.; Salvador, M. K.; Bortolozzi, R.; Basso, G.; Viola, G.; Balzarini, J.; Brancale, A.; Fu, X. H.; Li, J.; Zhang, S. Z.; Hamel, E.
  3. European Journal of Medicinal Chemistry. 2011, Dec; 46(12): 6015-6024.
  1. 16.   Design and Synthesis of 2-Heterocyclyl-3-arylthio-1H-indoles as Potent Tubulin Polymerization and Cell Growth Inhibitors with Improved Metabolic Stability
  2. La Regina, G.; Bai, R.; Rensen, W.; Coluccia, A.; Piscitelli, F.; Gatti, V.; Bolognesi, A.; Lavecchia, A.; Granata, I.; Porta, A.; Maresca, B.; Soriani, A.; Iannitto, M. L.; Mariani, M.; Santoni, A.; Brancale, A.; Ferlini, C.; Dondio, G.; Varasi, M.; Mercurio, C.; Hamel, E.; Lavia, P.; Novellino, E.; Silvestri, R.
  3. Journal of Medicinal Chemistry. 2011, Dec; 54(24): 8394-8406.
  1. 17.   Synthesis and Antitumor Molecular Mechanism of Agents Based on Amino 2-(3 ',4 ',5 '-Trimethoxybenzoyl)benzo[b]furan: Inhibition of Tubulin and Induction of Apoptosis
  2. Romagnoli, R.; Baraldi, P. G.; Lopez-Cara, C.; Cruz-Lopez, O.; Carrion, M. D.; Salvador, M. K.; Bermejo, J.; Estevez, S.; Estevez, F.; Balzarini, J.; Brancale, A.; Ricci, A.; Chen, L. C.; Kim, J. G.; Hamel, E.
  3. Chemmedchem. 2011, Oct; 6(10): 1841-1853.
  1. 18.   Synthesis and Biological Activities of (R)- and (S)-N-(4-Methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyri midin-4-aminium Chloride as Potent Cytotoxic Antitubulin Agents
  2. Ganglee, A.; Zhao, Y.; Hamel, E.; Westbrook, C.; Mooberry, S. L.
  3. Journal of Medicinal Chemistry. 2011, Sep; 54(17): 6151-6155.
  1. 19.   Discovery of 7-Hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a Tubulin Polymerization Inhibitor with Potent Antiproliferative and Tumor Vascular Disrupting Properties
  2. Flynn, B. L.; Gill, G. S.; Grobelny, D. W.; Chaplin, J. H.; Paul, D.; Leske, A. F.; Lavranos, T. C.; Chalmers, D. K.; Charman, S. A.; Kostewicz, E.; Shackleford, D. M.; Morizzi, J.; Hamel, E.; Jung, M. K.; Kremmidiotis, G.
  3. Journal of Medicinal Chemistry. 2011, Sep; 54(17): 6014-6027.
  1. 20.   Convergent Synthesis and Biological Evaluation of 2-Amino-4-(3 ',4 ',5 '-trimethoxyphenyl)-5-aryl Thiazoles as Microtubule Targeting Agents
  2. Romagnoli, R.; Baraldi, P. G.; Brancale, A.; Ricci, A.; Hamel, E.; Bortolozzi, R.; Basso, G.; Viola, G.
  3. Journal of Medicinal Chemistry. 2011, Jul; 54(14): 5144-5153.
  1. 21.   Interactions of Halichondrin B and Eribulin with Tubulin
  2. Bai, R. L.; Nguyen, T. L.; Burnett, J. C.; Atasoylu, O.; Munro, M. H. G.; Pettit, G. R.; Smith, A. B.; Gussio, R.; Hamel, E.
  3. Journal of Chemical Information and Modeling. 2011, Jun; 51(6): 1393-1404.
  1. 22.   Antitumor Agents. 284. New Desmosdumotin B Analogues with Bicyclic B-Ring as Cytotoxic and Antitubulin Agents
  2. Nakagawa-Goto, K.; Wu, P. C.; Lai, C. Y.; Hamel, E.; Zhu, H.; Zhang, L. Y.; Kozaka, T.; Ohkoshi, E.; Goto, M.; Bastow, K. F.; Lee, K. H.
  3. Journal of Medicinal Chemistry. 2011, Mar; 54(5): 1244-1255.
  1. 23.   Antitumor agents 273. Design and synthesis of N-alkyl-thiocolchicinoids as potential antitumor agents
  2. Kozaka, T.; Nakagawa-Goto, K.; Shi, Q. A.; Lai, C. Y.; Hamel, E.; Bastow, K. F.; Brossi, A.; Lee, K. H.
  3. Bioorganic & Medicinal Chemistry Letters. 2010, Jul; 20(14): 4091-4094.
  1. 24.   Substituted 2-(3 ',4 ',5 '-trimethoxybenzoyl)-benzo[b]thiophene derivatives as potent tubulin polymerization inhibitors
  2. Romagnoli, R.; Baraldi, P. G.; Carrion, M. D.; Cruz-Lopez, O.; Tolomeo, M.; Grimaudo, S.; Di Cristina, A.; Pipitone, M. R.; Balzarini, J.; Brancale, A.; Hamel, E.
  3. Bioorganic & Medicinal Chemistry. 2010, Jul; 18(14): 5114-5122.
  1. 25.   A Screen for Kinetochore-Microtubule Interaction Inhibitors Identifies Novel Antitubulin Compounds
  2. Screpanti, E.; Santaguida, S.; Nguyen, T.; Silvestri, R.; Gussio, R.; Musacchio, A.; Hamel, E.; De Wulf, P.
  3. Plos One. 2010, Jul; 5(7): 13.
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