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  1. 1.   Drug-Linker Constructs Bearing Unique Dual-Mechanism Tubulin Binding Payloads Tethered through Cleavable and Non-Cleavable Linkers
  2. Ford, Jacob W; VanNatta, Jennifer M; Mondal, Deboprosad; Lin, Chen-Ming; Deng, Yuling; Bai, Ruoli; Hamel,Ernest; Trawick, Mary Lynn; Pinney, Kevin G
  3. Tetrahedron. 2025, Feb 01; 171
  1. 2.   Design, Synthesis and Biological Evaluation of 2-Phenyl Indole Analogues of OXi8006 as Colchicine Site Inhibitors of Tubulin Polymerization and Vascular Disrupting Agents
  2. Vairin, Rebecca; Tamminga, Caleb; Shi, Zhe; Borchardt, Christian; Jambulapati, Jayaram; Bai, Ruoli; Wanniarachchi, Hashini; Bueno, Lorena; Hamel,Ernest; Mason, Ralph P; Trawick, Mary Lynn; Pinney, Kevin G
  3. Bioorganic & Medicinal Chemistry. 2024, Nov 07; 118: 117981.
  1. 3.   Synthesis and biological evaluation of structurally diverse 6-aryl-3-aroyl-indole analogues as inhibitors of tubulin polymerization
  2. Ren, Wen; Deng, Yuling; Ward, Jacob D; Vairin, Rebecca; Bai,Ruoli; Wanniarachchi, Hashini I; Hamal, Khagendra B; Tankoano, Pouguiniseli E; Tamminga, Caleb S; Bueno, Lorena M A; Hamel,Ernest; Mason, Ralph P; Trawick, Mary Lynn; Pinney, Kevin G
  3. European Journal of Medicinal Chemistry. 2023, Sep 06; 263: 115794.
  1. 4.   Novel Indole-Pyrazole Hybrids as Potential Tubulin-Targeting Agents; Synthesis, antiproliferative evaluation, and molecular modeling studies
  2. Hawash, Mohammed; Ergun, Sezen Guntekin; Kahraman, Deniz Cansen; Olgac, Abdurrahman; Hamel,Ernest; Cetin-Atalay, Rengul; Baytas, Sultan Nacak
  3. Journal of Molecular Structure. 2023, Aug 05; 1285
  1. 5.   Structure Guided Design, Synthesis, and Biological Evaluation of Oxetane-Containing Indole Analogues
  2. Ren, Wen; Vairin, Rebecca; Ward, Jacob D; Francis, Ricardo; VanNatta, Jenny; Bai,Ruoli; Tankoano, Pouguiniseli E; Deng, Yuling; Hamel,Ernest; Trawick, Mary Lynn; Pinney, Kevin G
  3. Bioorganic & Medicinal Chemistry. 2023, Jun 29; 92: 117400.
  1. 6.   Synthesis and Biological Evaluation of Highly Active 7-Anilino Triazolopyrimidines as Potent Antimicrotubule Agents
  2. Oliva, Paola; Romagnoli, Romeo; Cacciari, Barbara; Manfredini, Stefano; Padroni, Chiara; Brancale, Andrea; Ferla, Salvatore; Hamel,Ernest; Corallo, Diana; Aveic, Sanja; Milan, Noemi; Mariotto, Elena; Viola, Giampietro; Bortolozzi, Roberta
  3. Pharmaceutics. 2022, Jun 02; 14(6):
  1. 7.   A facile synthesis of diaryl pyrroles led to the discovery of potent colchicine site antimitotic agents
  2. Romagnoli, Romeo; Oliva, Paola; Salvador, Maria Kimatrai; Manfredini, Stefano; Padroni, Chiara; Brancale, Andrea; Ferla, Salvatore; Hamel,Ernest; Ronca, Roberto; Maccarinelli, Federica; Rruga, Fatlum; Mariotto, Elena; Viola, Giampietro; Bortolozzi, Roberta
  3. European Journal of Medicinal Chemistry. 2021, Mar 15; 214
  1. 8.   Insight on [1,3]thiazolo[4,5-e]isoindoles as tubulin polymerization inhibitors
  2. Spano, Virginia; Barreca, Marilia; Rocca, Roberta; Bortolozzi, Roberta; Bai, Ruoli; Carbone, Anna; Raimondi, Maria Valeria; Piccionello, Antonio Palumbo; Montalbano, Alessandra; Alcaro, Stefano; Hamel, Ernest; Viola, Giampietro; Barraja, Paola
  3. European Journal of Medicinal Chemistry. 2021, Feb 15; 212
  1. 9.   Pyrrolo[2 ',3 ':3,4]cyclohepta[1,2-d][1,2]oxazoles, a New Class of Antimitotic Agents Active against Multiple Malignant Cell Types
  2. Spano, Virginia; Rocca, Roberta; Barreca, Marilia; Giallombardo, Daniele; Montalbano, Alessandra; Carbone, Anna; Raimondi, Maria Valeria; Gaudio, Eugenio; Bortolozzi, Roberta; Bai,Ruoli; Tassone, Pierfrancesco; Alcaro, Stefano; Hamel,Ernest; Viola, Giampietro; Bertoni, Francesco; Barraja, Paola
  3. JOURNAL OF MEDICINAL CHEMISTRY. 2020, OCT 22; 63(20): 12023-12042.
  1. 10.   Synthesis and biological evaluation of structurally diverse alpha-conformationally restricted chalcones and related analogues
  2. Maguire, Casey J.; Carlson, Graham J.; Ford, Jacob W.; Strecker, Tracy E.; Hamel,Ernest; Trawick, Mary Lynn; Pinney, Kevin G.
  3. MedChemComm. 2019, Aug 1; 10(8): 1445-1456.
  1. 11.   Synthesis and biological evaluation of indole-2-carbohydrazides and thiazolidinyl-indole-2-carboxamides as potent tubulin polymerization inhibitors
  2. Kazan, Fusun; Yagci, Z Begum; Bai,Ruoli; Ozkirimli, Elif; Hamel,Ernest; Ozkirimli, Sumru
  3. Computational biology and chemistry. 2019, Jun; 80: 512-523.
  1. 12.   3-Aryl/Heteroaryl-5-amino-1-(3',4',5'-trimethoxybenzoyl)-1,2,4-triazoles as antimicrotubule agents. Design, synthesis, antiproliferative activity and inhibition of tubulin polymerization
  2. Romagnoli, Romeo; Prencipe, Filippo; Oliva, Paola; Baraldi, Stefania; Baraldi, Pier Giovanni; Brancale, Andrea; Ferla, Salvatore; Hamel, Ernest; Bortolozzi, Roberta; Viola, Giampietro
  3. Bioorganic chemistry. 2018, Oct; 80: 361-374.
  1. 13.   2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition
  2. Romagnoli, Romeo; Kimatrai Salvador, Maria; Schiaffino Ortega, Santiago; Baraldi, Pier Giovanni; Oliva, Paola; Baraldi, Stefania; Lopez-Cara, Luisa Carlota; Brancale, Andrea; Ferla, Salvatore; Hamel, Ernest; Balzarini, Jan; Liekens, Sandra; Mattiuzzo, Elena; Basso, Giuseppe; Viola, Giampietro
  3. European Journal of Medicinal Chemistry. 2018, Jan 1; 143: 683-698.
  1. 14.   Bioreductively activatable prodrug conjugates of phenstatin designed to target tumor hypoxia
  2. Winn, Blake A; Shi, Zhe; Carlson, Graham J; Wang, Yifan; Nguyen, Benson L; Kelly, Evan M; Ross, R David; Hamel, Ernest; Chaplin, David J; Trawick, Mary L; Pinney, Kevin G
  3. Bioorganic & medicinal chemistry letters. 2017, Feb 01; 27(3): 636-641.
  1. 15.   Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents
  2. Devkota, L.; Lin, C. M.; Strecker, T. E.; Wang, Y.; Tidmore, J. K.; Chen, Z.; Guddneppanavar, R.; Jelinek, C. J.; Lopez, R.; Liu, L.; Hamel, E.; Mason, R. P.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G.
  3. Bioorganic & Medicinal Chemistry. 2016, 1-Mar; 24(5): 938-56.
  1. 16.   Synthesis of novel antimitotic agents based on 2-amino-3-aroyl-5-(hetero)arylethynyl thiophene derivatives
  2. Romagnoli, R.; Baraldi, P. G.; Cruz-Lopez, O.; Tolomeo, M.; Di Cristina, A.; Pipitone, R. M.; Grimaudo, S.; Balzarini, J.; Brancale, A.; Hamel, E.
  3. Bioorganic & Medicinal Chemistry Letters. 2011, May; 21(9): 2746-2751.
  1. 17.   Structure-activity relationships of ustiloxin analogues
  2. Joullie, M. M.; Berritt, S.; Hamel, E.
  3. Tetrahedron Letters. 2011, Apr; 52(17): 2136-2139.
  1. 18.   Synthesis and Cellular Pharmacology Studies of a Series of 2-amino-3-aroyl-4-substituted Thiophene Derivatives
  2. Romagnoli, R.; Baraldi, P. G.; Pavani, M. G.; Cruz-Lopez, O.; Hamel, E.; Balzarini, J.; Brognara, E.; Zuccato, C.; Gambari, R.
  3. Medicinal Chemistry. 2010, Nov; 6(6): 329-343.
  1. 19.   Synthesis and Evaluation of Haloacetyl, alpha-Bromoacryloyl and Nitrooxyacetyl Benzo[b]furan and Benzo[b]thiophene Derivatives as Potent Antiproliferative Agents Against Leukemia L1210 and K562 Cells
  2. Romagnoli, R.; Baraldi, P. G.; Carrion, M. D.; Cara, C. L.; Casolari, A.; Hamel, E.; Fabbri, E.; Gambari, R.
  3. Letters in Drug Design & Discovery. 2010, Aug; 7(7): 476-486.
  1. 20.   Antitumor agents 273. Design and synthesis of N-alkyl-thiocolchicinoids as potential antitumor agents
  2. Kozaka, T.; Nakagawa-Goto, K.; Shi, Q. A.; Lai, C. Y.; Hamel, E.; Bastow, K. F.; Brossi, A.; Lee, K. H.
  3. Bioorganic & Medicinal Chemistry Letters. 2010, Jul; 20(14): 4091-4094.
  1. 21.   Substituted 2-(3 ',4 ',5 '-trimethoxybenzoyl)-benzo[b]thiophene derivatives as potent tubulin polymerization inhibitors
  2. Romagnoli, R.; Baraldi, P. G.; Carrion, M. D.; Cruz-Lopez, O.; Tolomeo, M.; Grimaudo, S.; Di Cristina, A.; Pipitone, M. R.; Balzarini, J.; Brancale, A.; Hamel, E.
  3. Bioorganic & Medicinal Chemistry. 2010, Jul; 18(14): 5114-5122.
  1. 22.   Synthesis and Antitumor Activity of 1,5-Disubstituted 1,2,4-Triazoles as Cis-Restricted Combretastatin Analogues
  2. Romagnoli, R.; Baraldi, P. G.; Cruz-Lopez, O.; Cara, C. L.; Carrion, M. D.; Brancale, A.; Hamel, E.; Chen, L. C.; Bortolozzi, R.; Basso, G.; Viola, G.
  3. Journal of Medicinal Chemistry. 2010, May; 53(10): 4248-4258.
  1. 23.   Synthesis, Antitubulin, and Antiproliferative SAR of Analogues of 2-Methoxyestradiol-3,17-O,O-bis-sulfamate
  2. Jourdan, F.; Leese, M. P.; Dohle, W.; Hamel, E.; Ferrandis, E.; Newman, S. P.; Purohit, A.; Reed, M. J.; Potter, B. V. L.
  3. Journal of Medicinal Chemistry. 2010, Apr; 53(7): 2942-2951.
  1. 24.   A boronic acid chalcone analog of combretastatin A-4 as a potent anti-proliferation agent
  2. Kong, Y. L.; Wang, K.; Edler, M. C.; Hamel, E.; Mooberry, S. L.; Paige, M. A.; Brown, M. L.
  3. Bioorganic & Medicinal Chemistry. 2010, Jan; 18(2): 971-977.
  1. 25.   A diaryl sulfide, sulfoxide, and sulfone bearing structural similarities to combretastatin A-4
  2. Barbosa, E. G.; Bega, L.; Beatriz, A.; Sarkar, T.; Hamel, E.; do Amaral, M. S.; de Lima, D. P.
  3. European Journal of Medicinal Chemistry. 2009 44(6): 2685-2688.
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