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  1. 1.   Crystal structures of clinically relevant Lys103Asn/Tyr181Cys double mutant HIV-1 reverse transcriptase in complexes with ATP and non-nucleoside inhibitor HBY 097
  2. Das, K.; Sarafianos, S. G.; Clark, A. D.; Boyer, P. L.; Hughes, S. H.; Arnold, E.
  3. Journal of Molecular Biology. 2007, Jan; 365(1): 77-89.
  1. 2.   Structural mimicry of CD4 by a cross-reactive HIV-1 neutralizing antibody with CDR-H2 and H3 containing unique motifs
  2. Prabakaran, P.; Gan, J. H.; Wu, Y. Q.; Zhang, M. Y.; Dimitrov, D. S.; Ji, X. H.
  3. Journal of Molecular Biology. 2006, MAR 17; 357(1): 82-99.
  1. 3.   HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site
  2. Himmel, D. M.; Sarafianos, S. G.; Dharmasena, S.; Hossain, M. M.; McCoy-Simandle, K.; Ilina, T.; Clark, A. D.; Knight, J. L.; Julias, J. G.; Clark, P. K.; Krogh-Jespersen, K.; Levy, R. M.; Hughes, S. H.; Parniak, M. A.; Arnold, E.
  3. Acs Chemical Biology. 2006 1(11): 702-712.
  1. 4.   Crystal structures for HIV-1 reverse transcriptase in complexes with three pyridinone derivatives: A new class of non-nucleoside inhibitors effective against a broad range of drug-resistant strains
  2. Himmel, D. M.; Das, K.; Clark, A. D.; Hughes, S. H.; Benjahad, A.; Oumouch, S.; Guillemont, J.; Coupa, S.; Poncelet, A.; Csoka, I.; Meyer, C.; Andries, K.; Nguyen, C. H.; Grierson, D. S.; Arnold, E.
  3. Journal of Medicinal Chemistry. 2005, DEC 1; 48(24): 7582-7591.
  1. 5.   Crystal structure of the broadly cross-reactive HIV-1-neutralizing Fab X5 and fine mapping of its epitope
  2. Darbha, R.; Phogat, S.; Labrijn, A. F.; Shu, Y.; Gu, Y. J.; Andrykovitch, M.; Zhang, M. Y.; Pantophlet, R.; Martin, L.; Vita, C.; Burton, D. R.; Dimitrov, D. S.; Ji, X. H.
  3. Biochemistry. 2004 43(6): 1410-1417.
  1. 6.   Nonnucleoside inhibitor binding affects the interactions of the fingers subdomain of human immunodeficiency virus type 1 reverse transcriptase with DNA
  2. Peletskaya, E. N.; Kogon, A. A.; Tuske, S.; Arnold, E.; Hughes, S. H.
  3. Journal of Virology. 2004 78(7): 3387-3397.
  1. 7.   Trapping HIV-1 reverse transcriptase before and after translocation on DNA
  2. Sarafianos, S. G.; Clark, A. D.; Tuske, S.; Squire, C. J.; Das, K.; Sheng, D. Q.; Ilankumaran, P.; Ramesha, A. R.; Kroth, H.; Sayer, J. M.; Jerina, D. M.; Boyer, P. L.; Hughes, S. H.; Arnold, E.
  3. Journal of Biological Chemistry. 2003 278(18): 16280-16288.
  1. 8.   Multiple interactions across the surface of the gp120 core structure determine the global neutralization resistance phenotype of human immunodeficiency virus type 1
  2. Bouma, P.; Leavitt, M.; Zhang, P. F.; Sidorov, I. A.; Dimitrov, D. S.; Quinnan, G. V.
  3. Journal of Virology. 2003 77(14): 8061-8071.
  1. 9.   Cyanovirin-N, a potent human immunodeficiency virus- inactivating protein, blocks both CD4-dependent and CD4- independent binding of soluble gp120 (sgp120) to target cells, inhibits sCD4-induced binding of sgp120 to cell-associated CXCR4, and dissociates bound sgp120 from target cells
  2. Mori, T.; Boyd, M. R.
  3. Antimicrobial Agents and Chemotherapy. 2001 45(3): 664-672.
  1. 10.   Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA : DNA
  2. Sarafianos, S. G.; Das, K.; Tantillo, C.; Clark, A. D.; Ding, J.; Whitcomb, J. M.; Boyer, P. L.; Hughes, S. H.; Arnold, E.
  3. Embo Journal. 2001 20(6): 1449-1461.
  1. 11.   The Lys103Asn mutation of HIV-1 RT: A novel mechanism of drug resistance
  2. Hsiou, Y.; Ding, J. P.; Das, K.; Clark, A. D.; Boyer, P. L.; Lewi, P.; Janssen, P. A. J.; Kleim, J. P.; Rosner, M.; Hughes, S. H.; Arnold, E.
  3. Journal of Molecular Biology. 2001 309(2): 437-445.
  1. 12.   Discovery of Cyanovirin-N, a Novel Human Immunodeficiency Virus-Inactivating Protein That Binds Viral Surface Envelope Glycoprotein Gp120 - Potential Applications to Microbicide Development
  2. Boyd, M. R.; Gustafson, K. R.; McMahon, J. B.; Shoemaker, R. H.; Okeefe, B. R.; Mori, T.; Gulakowski, R. J.; Wu, L.; Rivera, M. I.; Laurencot, C. M.; Currens, M. J.; Cardellina, J. H.; Buckheit, R. W.; Nara, P. L.; Pannell, L. K.; Sowder, R. C.; Henderson, L. E.
  3. Antimicrobial Agents and Chemotherapy. 1997 41(7): 1521-1530.
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