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  1. 1.   Phase I trial of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a heat shock protein inhibitor, administered twice weekly in patients with advanced malignancies
  2. Kummar, S.; Gutierrez, M. E.; Gardner, E. R.; Chen, X. H.; Figg, W. D.; Zajac-Kaye, M.; Chen, M.; Steinberg, S. M.; Muir, C. A.; Yancey, M. A.; Horneffer, Y. R.; Juwara, L.; Melillo, G.; Ivy, S. P.; Merino, M.; Neckers, L.; Steeg, P. S.; Conley, B. A.; Giaccone, G.; Doroshow, J. H.; Murgo, A. J.
  3. European Journal of Cancer. 2010, Jan; 46(2): 340-347.
  1. 2.   In vivo antitumor efficacy of 17-DMAG (17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride), a water-soluble geldanamycin derivative
  2. Hollingshead, M.; Alley, M.; Burger, A. M.; Borgel, S.; Pacula-Cox, C.; Fiebig, H. H.; Sausville, E. A.
  3. Cancer Chemotherapy and Pharmacology. 2005, AUG; 56(2): 115-125.
  1. 3.   Enhanced tumor cell radiosensitivity and abrogation of G(2) and S phase arrest by the Hsp90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin
  2. Bull, E. E. A.; Dote, H.; Brady, K. J.; Burgan, W. E.; Carter, D. J.; Cerra, M. A.; Oswald, K. A.; Hollingshead, M. G.; Camphausen, K.; Tofilon, P. J.
  3. Clinical Cancer Research. 2004, DEC 1; 10(23): 8077-8084.
  1. 4.   Characterization of programmed cell death 4 in multiple human cancers reveals a novel enhancer of drug sensitivity
  2. Jansen, A. P.; Camalier, C. E.; Stark, C.; Colburn, N. H.
  3. Molecular Cancer Therapeutics. 2004 3(2): 103-110.
  1. 5.   The impact of tumor location on the activity of 17-DMAG (NSC 707545), a water soluble geldanamycin analog
  2. Borgel, S. D.; Carter, J. P.; Sausville, E. E.; Hollingshead, M. G.
  3. Clinical Cancer Research. 2003 9(16): 6215S-6215S.
  1. 6.   Different early effects of tyrphostin AG957 and geldanamycins on mitogen-activated protein kinase and p120(cbl) phosphorylation in anti CD-3-stimulated T-lymphoblasts
  2. Losiewicz, M. D.; Kaur, G.; Sausville, E. A.
  3. Biochemical Pharmacology. 1999 57(3): 281-289.
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