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  1. 1.   Inactivation of the von Hippel-Lindau tumor suppressor leads to selective expression of a human endogenous retrovirus in kidney cancer
  2. Cherkasova, E.; Malinzak, E.; Rao, S.; Takahashi, Y.; Senchenko, V. N.; Kudryavtseva, A. V.; Nickerson, M. L.; Merino, M.; Hong, J. A.; Schrump, D. S.; Srinivasan, R.; Linehan, W. M.; Tian, X.; Lerman, M. I.; Childs, R. W.
  3. Oncogene. 2011, Nov; 30(47): 4697-4706.
  1. 2.   RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis
  2. Lipkowitz, S.; Weissman, A. M.
  3. Nature Reviews Cancer. 2011, Sep; 11(9): 629-643.
  1. 3.   The chemokine CXCL12 and its receptor CXCR4 promote glioma stem cell-mediated VEGF production and tumour angiogenesis via PI3K/AKT signalling
  2. Ping, Y. F.; Yao, X. H.; Jiang, J. Y.; Zhao, L. T.; Yu, S. C.; Jiang, T.; Lin, M. C. M.; Chen, J. H.; Wang, B.; Zhang, R.; Cui, Y. H.; Qian, C.; Wang, J. M.; Bian, X. W.
  3. Journal of Pathology. 2011, Jul; 224(3): 344-354.
  1. 4.   ASPS-1, A Novel Cell Line Manifesting Key Features of Alveolar Soft Part Sarcoma
  2. Kenney, S.; Vistica, D. T.; Stockwin, L. H.; Burkett, S.; Hollingshead, M. G.; Borgel, S. D.; Butcher, D. O.; Schrump, D. S.; Shoemaker, R. H.
  3. Journal of Pediatric Hematology Oncology. 2011, Jul; 33(5): 360-368.
  1. 5.   Large-scale Exploration of Gene-Gene Interactions in Prostate Cancer Using a Multistage Genome-wide Association Study
  2. Ciampa, J.; Yeager, M.; Amundadottir, L.; Jacobs, K.; Kraft, P.; Chung, C.; Wacholder, S.; Yu, K.; Wheeler, W.; Thun, M. J.; Divers, W. R.; Gapstur, S.; Albanes, D.; Virtamo, J.; Weinstein, S.; Giovannucci, E.; Willett, W. C.; Cancel-Tassin, G.; Cussenot, O.; Valeri, A.; Hunter, D.; Hoover, R.; Thomas, G.; Chanock, S.; Chatterjee, N.
  3. Cancer Research. 2011, May; 71(9): 3287-3295.
  1. 6.   The tumour suppressor C/EBP delta inhibits FBXW7 expression and promotes mammary tumour metastasis
  2. Balamurugan, K.; Wang, J. M.; Tsai, H. H.; Sharan, S.; Anver, M.; Leighty, R.; Sterneck, E.
  3. Embo Journal. 2010, Dec; 29(24): 4106-4117.
  1. 7.   Aminoflavone, a Ligand of the Aryl Hydrocarbon Receptor, Inhibits HIF-1 alpha Expression in an AhR-Independent Fashion
  2. Terzuoli, E.; Puppo, M.; Rapisarda, A.; Uranchimeg, B.; Cao, L. A.; Burger, A. M.; Ziche, M.; Melillo, G.
  3. Cancer Research. 2010, Sep 1; 70(17): 6837-6848.
  1. 8.   Development of HIF-1 inhibitors for cancer therapy
  2. Onnis, B.; Rapisarda, A.; Melillo, G.
  3. Journal of Cellular and Molecular Medicine. 2009, Sep; 13(9A): 2780-6.
  1. 9.   Cytotoxic and HIF-1alpha inhibitory compounds from Crossosoma bigelovii
  2. Klausmeyer, P.; Zhou, Q.; Scudiero, D. A.; Uranchimeg, B.; Melillo, G.; Cardellina, J. H.; Shoemaker, R. H.; Chang, C. J.; McCloud, T. G.
  3. Journal of Natural Products. 2009, May 22; 72(5): 805-12.
  1. 10.   Metal Ions-Stimulated Iron Oxidation in Hydroxylases Facilitates Stabilization of HIF-1 alpha Protein
  2. Kaczmarek, M.; Cachau, R. E.; Topol, I. A.; Kasprzak, K. S.; Ghio, A.; Salnikow, K.
  3. Toxicological Sciences. 2009 107(2): 394-403.
  1. 11.   Therapeutic Vulnerability of an In Vivo Model of Alveolar Soft Part Sarcoma (ASPS) to Antiangiogenic Therapy
  2. Vistica, D. T.; Hollingshead, M.; Borgel, S. D.; Kenney, S.; Stockwin, L. H.; Raffeld, M.; Schrump, D. S.; Burkett, S.; Stone, G.; Butcher, D. O.; Shoemaker, R. H.
  3. Journal of Pediatric Hematology Oncology. 2009 31(8): 561-570.
  1. 12.   UVC inhibits HIF-1 alpha protein translation by a DNA damage- and topoisomerase I-independent pathway
  2. Rapisarda, A.; Melillo, G.
  3. Oncogene. 2007, Oct; 26(48): 6875-6884.
  1. 13.   Expression of hypoxia-inducible factor 1 alpha, hypoxia-inducible factor 2 alpha, and von Hippel-Lindau protein in epitheLiaL ovarian neoplasms and allelic loss of von Hippel-Lindau gene: nuclear expression of hypoxia-inducible factor 1 alpha is an independent prognostic factor in ovarian carcinoma
  2. Osada, R.; Horiuchi, A.; Kikuchi, N.; Yoshida, J.; Hayashi, A.; Ota, M.; Katsuyama, Y.; Melilo, G.; Konishi, I.
  3. Human Pathology. 2007, Sep; 38(9): 1310-1320.
  1. 14.   The role of ascorbate in the modulation of HIF-1 alpha protein and HIF-dependent transcription by chromium(VI) and nickel(II)
  2. Kaczmarek, M.; Timofeeva, O. A.; Karaczyn, A.; Malyguine, A.; Kasprzak, K. S.; Salnikow, K.
  3. Free Radical Biology and Medicine. 2007, Apr; 42(8): 1246-1257.
  1. 15.   Identification of a new natural camptothecin analogue in targeted screening for HIF-1 alpha inhibitors
  2. Klausmeyer, P.; McCloud, T. G.; Melillo, G.; Scudiero, D. A.; Cardellina, J. H.; Shoemaker, R. H.
  3. Planta Medica. 2007, Jan; 73(1): 49-52.
  1. 16.   Expression of hypoxia inducible factor-1 alpha and 2 alpha in genetically distinct early renal cortical tumors
  2. Kim, C. M.; Vocke, C.; Torres-Cabala, C.; Yang, Y. F.; Schmidt, L.; Walther, M.; Linehan, W. M.
  3. Journal of Urology. 2006, May; 175(5): 1908-1914.
  1. 17.   Meeting report: Exploiting the Tumor Microenvironment for Therapeutics
  2. Melillo, G.; Semenza, G. L.
  3. Cancer Research. 2006, MAY 1; 66(9): 4558-4560.
  1. 18.   Quantum chemical modeling of reaction mechanism for 2-oxoglutarate dependent enzymes: Effect of substitution of iron by nickel and cobalt
  2. Topol, I. A.; Nemukhin, A. V.; Salnikow, K.; Cachau, R. E.; Abashkin, Y. G.; Kasprzak, K. S.; Burt, S. K.
  3. Journal of Physical Chemistry A. 2006, Mar; 110(12): 4223-4228.
  1. 19.   Lights on for low oxygen: A noninvasive mouse model useful for sensing oxygen deficiency
  2. Schmid, T.; Young, M. R.
  3. Molecular Interventions. 2006, Feb; 6(1): 20-22.
  1. 20.   Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity
  2. Kong, D. H.; Park, E. J.; Stephen, A. G.; Calvani, M.; Cardellina, J. H.; Monks, A.; Fisher, R. J.; Shoemaker, R. H.; Melillo, G.
  3. Cancer Research. 2005, OCT 1; 65(19): 9047-9055.
  1. 21.   Topotecan blocks hypoxia-inducible factor-1 alpha, and vascular endothelial growth factor expression induced by insulin-like growth factor-I in neuroblastoma cells
  2. Beppu, Y.; Nakamura, K.; Linehan, W. M.; Rapisarda, A.; Thiele, C. J.
  3. Cancer Research. 2005, JUN 1; 65(11): 4775-4781.
  1. 22.   Cited1 is a bifunctional transcriptional cofactor that regulates early nephronic patterning
  2. Plisov, S.; Tsang, M.; Shi, G. B.; Boyle, S.; Yoshino, K.; Dunwoodie, S. L.; Dawid, I. B.; Shioda, T.; Perantoni, A. O.; de Caestecker, M. P.
  3. Journal of the American Society of Nephrology. 2005, JUN; 16(6): 1632-1644.
  1. 23.   Linking tumor cell cytotoxicity to mechanism of drug action: An integrated analysis of gene expression, small-molecule screening and structural databases
  2. Covell, D. G.; Wallqvist, A.; Huang, R. L.; Thanki, N.; Rabow, A. A.; Lu, X. J.
  3. Proteins-Structure Function and Bioinformatics. 2005, MAY 15; 59(3): 403-433.
  1. 24.   Ascorbate depletion: A critical step in nickel carcinogenesis?
  2. Salnikow, K.; Kasprzak, K. S.
  3. Environmental Health Perspectives. 2005, MAY; 113(5): 577-584.
  1. 25.   Schedule-dependent inhibition of hypoxia-inducible factor-1 alpha protein accumulation, angiogenesis, and tumor growth by topotecan in U251-HRE glioblastoma xenografts
  2. Rapisarda, A.; Zalek, J.; Hollingshead, M.; Braunschweig, T.; Uranchimeg, B.; Bonomi, C. A.; Borgel, S. D.; Carter, J. P.; Hewitt, S. M.; Shoemaker, R. H.; Melillo, G.
  3. Cancer Research. 2004, OCT 1; 64(19): 6845-6848.
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