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  1. 1.   Preclinical Therapeutic Efficacy of RAF/MEK/ERK and IGF1R/AKT/mTOR Inhibition in Neuroblastoma
  2. Stauffer,Stacey; Roth, Jacob S; Hernandez, Edjay R; Kowalczyk, Joshua T; Sealover, Nancy E; Hebron,Katie; James,Amy; Isanogle,Kristine; Riffle, Lisa A; Ileva,Lilia; Luo, Xiaoling; Chen, Jin-Qiu; Kedei, Noemi; Kortum, Robert L; Lei, Haiyan; Shern, Jack F; Kalen,Joseph; Edmondson, Elijah F; Hall, Matthew D; Difilippantonio,Simone; Thiele, Carol J; Yohe,Marielle
  3. Cancers. 2024, Jun 25; 16(13):
  1. 2.   In Vivo Treatment with Insulin-like Growth Factor 1 Reduces CCR5 Expression on Vaccine-Induced Activated CD4+ T-Cells
  2. Bissa, Massimiliano; Galli, Veronica; Schifanella, Luca; Vaccari, Monica; Rahman, Mohammad Arif; Gorini, Giacomo; Binello, Nicolò; Sarkis, Sarkis; Gutowska, Anna; Silva de Castro, Isabela; Doster, Melvin N; Moles, Ramona; Ferrari, Guido; Shen, Xiaoying; Tomaras, Georgia D; Montefiori, David C; N'guessan, Kombo F; Paquin-Proulx, Dominic; Kozlowski, Pamela A; Venzon, David J; Choo-Wosoba, Hyoyoung; Breed,Matthew; Kramer,Josh; Franchini, Genoveffa
  3. Vaccines. 2023, Oct 30; 11(11):
  1. 3.   Bladder urothelial carcinoma producing insulin-like growth factor II: A case report
  2. Funada, Satoshi; Kita, Yuki; Okada, Yoshiyuki; Kobayashi, Takashi; Teramoto, Yuki; Shibuya, Shinsuke; Saito, Ryoichi; Murakami, Kaoru; Matsumoto, Keiyu; Feng,Yang; Dimitrov, Dimiter S; Inoue, Takahiro; Ogawa, Osamu
  3. IJU case reports. 2018, Nov; 1(1): 9-12.
  1. 4.   Inhibitors of STAT3, ß-catenin, and IGF-1R sensitize mouse PIK3CA mutant breast cancer to PI3K inhibitors
  2. Merino, Vanessa F; Cho, Soonweng; Liang, Xiaohui; Park, Sunju; Jin, Kideok; Chen, Qian; Pan, Duojia; Zahnow, Cynthia A; Rein, Alan; Sukumar, Saraswati
  3. Molecular Oncology. 2017, Mar 15; 11(5): 552-566.
  1. 5.   Human Monoclonal Antibody Fragments Binding to Insulin-like Growth Factors I and II with Picomolar Affinity
  2. Zhao, Q.; Feng, Y.; Zhu, Z. Y.; Dimitrov, D. S.
  3. Molecular Cancer Therapeutics. 2011, Sep; 10(9): 1677-1685.
  1. 6.   Insulin-like growth factor 1 receptor antibody induces rhabdomyosarcoma cell death via a process involving AKT and Bcl-x(L)
  2. Mayeenuddin, L. H.; Yu, Y.; Kang, Z.; Helman, L. J.; Cao, L.
  3. Oncogene. 2010, Dec; 29(48): 6367-6377.
  1. 7.   Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium
  2. Canzian, F.; Cox, D. G.; Setiawan, V. W.; Stram, D. O.; Ziegler, R. G.; Dossus, L.; Beckmann, L.; Blanche, H.; Barricarte, A.; Berg, C. D.; Bingham, S.; Buring, J.; Buys, S. S.; Calle, E. E.; Chanock, S. J.; Clavel-Chapelon, F.; DeLancey, J. O. L.; Diver, W. R.; Dorronsoro, M.; Haiman, C. A.; Hallmans, G.; Hankinson, S. E.; Hunter, D. J.; Husing, A.; Isaacs, C.; Khaw, K. T.; Kolonel, L. N.; Kraft, P.; Le Marchand, L.; Lund, E.; Overvad, K.; Panico, S.; Peeters, P. H. M.; Pollak, M.; Thun, M. J.; Tjonnel, A.; Trichopoulos, D.; Tumino, R.; Yeager, M.; Hoover, R. N.; Riboli, E.; Thomas, G.; Henderson, B. E.; Kaaks, R.; Feigelson, H. S.
  3. Human Molecular Genetics. 2010, Oct; 19(19): 3873-3884.
  1. 8.   Targeting of Bone-Derived Insulin-Like Growth Factor-II by a Human Neutralizing Antibody Suppresses the Growth of Prostate Cancer Cells in a Human Bone Environment
  2. Kimura, T.; Kuwata, T.; Ashimine, S.; Yamazaki, M.; Yamauchi, C.; Nagai, K.; Ikehara, A.; Feng, Y.; Dimitrov, D. S.; Saito, S.; Ochiai, A.
  3. Clinical Cancer Research. 2010, Jan; 16(1): 121-129.
  1. 9.   Characterization of a chimeric monoclonal antibody against the insulin-like growth factor-I receptor
  2. Zhang, M. Y.; Feng, Y.; Wang, Y.; Dimitrov, D. S.
  3. Mabs. 2009, Sep-Oct; 1(5): 475-80.
  1. 10.   Exercise Effects on Tumorigenesis in a p53-Deficient Mouse Model of Breast Cancer
  2. Colbert, L. H.; Westerlind, K. C.; Perkins, S. N.; Haines, D. C.; Berrigan, D.; Donehower, L. A.; Fuchs-Young, R.; Hursting, S. D.
  3. Medicine and Science in Sports and Exercise. 2009 41(8): 1597-1605.
  1. 11.   Addiction to elevated insulin-like growth factor I receptor and initial modulation of the AKT pathway define the responsiveness of rhabdomyosarcoma to the targeting antibody
  2. Cao, L.; Yu, Y. K.; Darko, I.; Currier, D.; Mayeenuddin, L. H.; Wan, X. L.; Khanna, C.; Helman, L. J.
  3. Cancer Research. 2008 68(19): 8039-8048.
  1. 12.   Monoclonal antibodies against components of the IGF system for cancer treatment
  2. Feng, Y.; Dimitrov, D. S.
  3. Current Opinion in Drug Discovery & Development. 2008 11(2): 178-185.
  1. 13.   Down-regulation of insulin-like growth factor binding protein-5 (IGFBP-5): Novel marker for cervical carcinogenesis
  2. Miyatake, T.; Ueda, Y.; Nakashima, R.; Yoshino, K.; Kimura, T.; Murata, T.; Nomura, T.; Fujita, M.; Buzard, G. S.; Enomoto, T.
  3. International Journal of Cancer. 2007, May; 120(10): 2068-2077.
  1. 14.   Novel human monoclonal antibodies to insulin-like growth factor (IGH)-II that potently inhibit the IGF receptor type I signal transduction function
  2. Feng, Y.; Zhu, Z. Y.; Xiao, X. D.; Choudhry, V.; Barrett, J. C.; Dimitrov, D. S.
  3. Molecular Cancer Therapeutics. 2006, JAN; 5(1): 114-120.
  1. 15.   Topotecan blocks hypoxia-inducible factor-1 alpha, and vascular endothelial growth factor expression induced by insulin-like growth factor-I in neuroblastoma cells
  2. Beppu, Y.; Nakamura, K.; Linehan, W. M.; Rapisarda, A.; Thiele, C. J.
  3. Cancer Research. 2005, JUN 1; 65(11): 4775-4781.
  1. 16.   Lsh controls silencing of the imprinted Cdkn1c gene
  2. Fan, T.; Hagan, J. P.; Kozlov, S. V.; Stewart, C. L.; Muegge, K.
  3. Development. 2005, FEB; 132(4): 635-644.
  1. 17.   Intraspecific mating with CzechII/Ei mice rescue lethality associated with loss of function mutations of the imprinted genes, Igf2r and Cdkn1c
  2. Hagan, J. P.; Kozlov, S. V.; Chiang, Y. S.; Sewell, L.; Stewart, C. L.
  3. Genomics. 2004, NOV; 84(5): 836-843.
  1. 18.   Activating mutations in STAT3 and STAT5 differentially affect cellular proliferation and apoptotic resistance in multiple myeloma cells
  2. Hodge, D. R.; Xiao, W. H.; Wang, L. H.; Li, D. P.; Farrar, W. L.
  3. Cancer Biology & Therapy. 2004 3(2): 188-194.
  1. 19.   Effects of organ-specific loss of insulin-like growth factor-I production on murine hematopoiesis
  2. Welniak, L. A.; Karas, M.; Yakar, S.; Anver, M. R.; Murphy, W. F.; LeRoith, D.
  3. Biology of Blood and Marrow Transplantation. 2004 10(1): 32-39.
  1. 20.   Critical prosurvival roles for C/EBP beta and insulin-like growth factor I in macrophage tumor cells
  2. Wessells, J.; Yakar, S.; Johnson, P. F.
  3. Molecular and Cellular Biology. 2004 24(8): 3238-3250.
  1. 21.   Paternal and maternal genomes confer opposite effects on proliferation, cell-cycle length, senescence, and tumor formation
  2. Hernandez, L.; Kozlov, S.; Piras, G.; Stewart, C. L.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2003 100(23): 13344-13349.
  1. 22.   Serum insulin-like growth factor 1: Tumor marker or etiologic factor? A prospective study of prostate cancer among Finnish men
  2. Woodson, K.; Tangrea, J. A.; Pollak, M.; Copeland, T. D.; Taylor, P. R.; Virtamo, J.; Albanes, D.
  3. Cancer Research. 2003 63(14): 3991-3994.
  1. 23.   Increased K-ras protein and activity in mouse and human lung epithelial cells at confluence
  2. Kammouni, W.; Ramakrishna, G.; Sithanandam, G.; Smith, G. T.; Fornwald, L. W.; Masuda, A.; Takahashi, T.; Anderson, L. M.
  3. Cell Growth and Differentiation. 2002 13(9): 441-448.
  1. 24.   Effects of growth hormone and prolactin on hematopoiesis
  2. Welniak, L. A.; Tian, Z. G.; Sun, R.; Keller, J. R.; Richards, S.; Ruscetti, F. W.; Murphy, W. J.
  3. Leukemia & Lymphoma. 2000 38(5-6): 435-445.
  1. 25.   Pilot Study of the Immunologic Effects of Recombinant Human Growth Hormone and Recombinant Insulin-Like Growth Factor in Hiv-Infected Patients
  2. Nguyen, B. Y.; Clerici, M.; Venzon, D. J.; Bauza, S.; Murphy, W. J.; Longo, D. L.; Baseler, M.; Gesundheit, N.; Broder, S.; Shearer, G.; Yarchoan, R.
  3. Aids. 1998 12(8): 895-904.
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