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  1. 1.   Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy
  2. Phelps, Catherine M; Willis, Nathaniel B; Duan, Tingting; Lee, Amanda H; Zhang, Yue; Rodriguez J, Daphne M; Pandey, Surya P; Laughlin, Colin R; Rosen, Aaron B I; McPherson, Alex C; Shapira, Jake H; Randhawa, Simran K; Hedden, Lee; Richie, Tanner G; Wiechman, Hallie M; Bender, Mackenzie J; Nemet, Ina; Zöhrer, Patrick A; Gottschalk, Rachel A; Schmitz, Kathryn H; Mullett, Steven J; Gelhaus, Stacy L; Davar, Diwakar; Zarour, Hassane M; Hinterleitner, Reinhard; Mossington, Thomas; Badger, Jonathan H; Rodrigues,Richard; McCulloch, John A; Lee, Sonny T M; Wagner, Karl-Heinz; Winter, Maria G; Winter, Sebastian E; Das, Jishnu; Pierre, Joseph F; Trinchieri, Giorgio; Meisel, Marlies
  3. Cell. 2025, Jul 04;
  1. 2.   Polymerase theta inhibitors combinations with approved and investigational agents in patient-derived tumor multi-cell type (mct) spheroids
  2. Teicher, Beverly A; Dexheimer,Thomas; Chen,Li; Silvers, Thomas; Jones,Eric; Coussens,Nathan; Eder, J Paul; Doroshow, James H
  3. Experimental and Molecular Pathology. 2025, Jun 27; 143: 104978.
  1. 3.   5hmC enhances PARP trapping and restores PARP inhibitor sensitivity in chemoresistant BRCA1/2-deficient cells
  2. Kharat, Suhas S; Mishra,Arun; Sengodan,Satheesh; Dierman, Dillon; Fox, Stephen D; Chazin, Walter J; Sharan,Shyam
  3. The Journal of Biological Chemistry. 2025, Jun 19; 110393.
  1. 4.   Benzosuberene and Tetracyclic Analogues as Colchicine Site Inhibitors of Tubulin Polymerization
  2. VanNatta, Jennifer M; Carlson, Graham J; Niu, Haichan; Bai, Ruoli; Wanniarachchi, Hashini I; Schuetze, Regan; Trawick, Mary Lynn; Hamel,Ernest; Mason, Ralph P; Pinney, Kevin G
  3. ACS Medicinal Chemistry Letters. 2025, Jun 12; 16(6): 1098-1107.
  1. 5.   Biophysical and structural analysis of KRAS switch-II pocket inhibitors reveals allele-specific binding constraints
  2. Alexander,Patrick; Chan,Albert; Rabara,Dana; Swain,Monalisa; Larsen,Erik; Dyba,Marcin; Chertov,Oleg; Ashraf, Mariam; Champagne,Alysia; Lin, Ken; Maciag,Anna; Gillette,William; Nissley,Dwight; McCormick, Frank; Simanshu,Dhirendra; Stephen,Andrew
  3. The Journal of Biological Chemistry. 2025, Jun 03; 110331.
  1. 6.   Neovascular pruning by IDO1 inhibitors can potentiate immunogenic cytotoxicity of ischemia-targeted agents to synergistically enhance anti-PD-1 responsiveness
  2. Shen, Shih-Chun; Dey, Souvik; DuHadaway, James B; Sutanto-Ward, Erika; Hampton, Maurice T; Kozlov,Serguei; Prendergast, George C; Muller, Alexander J
  3. Journal for Immunotherapy of Cancer. 2025, May 30; 13(5):
  1. 7.   Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine
  2. Maciag,Anna; Yang, Yue; Sharma,Alok; Turner,David; Dehart,Caroline; Abdelkarim, Hazem; Fan,Lixin; Smith,Brian; Kumari,Vandana; Dyba,Marcin; Rigby,Megan; Castillo Badillo,Jean; Adams, Lauren; Fornelli, Luca; Fox, Stephen; Brafman, Alla; Turbyville,Thomas; Gillette,William; Messing,Simon; Agamasu, Constance; Wolfe, Andrew L; Gysin, Stephan; Chan, Albert H; Simanshu,Dhirendra; Esposito,Dominic; Chertov,Oleg; Stephen,Andrew; Arkin, Michelle; Renslo, Adam; Kelleher, Neil L; Gaponenko, Vadim; Lightstone, Felice C; Nissley,Dwight; McCormick, Frank
  3. Proceedings of the National Academy of Sciences of the United States of America. 2025, May 13; 122(19): e2410766122.
  1. 8.   Distinct allosteric networks in CDK4 and CDK6 in the cell cycle and in drug resistance
  2. Zhang,Wengang; Bradburn, Devin; Heidebrink, Gretchen; Liu, Yonglan; Jang,Hyunbum; Nussinov,Ruth; Kõivomägi, Mardo
  3. Journal of Molecular Biology. 2025, Mar 31; 169121.
  1. 9.   Olaparib in treatment-refractory isocitrate dehydrogenase 1 (IDH1)- and IDH2-mutant cholangiocarcinoma: Safety and antitumor activity from the phase 2 National Cancer Institute 10129 trial
  2. Cecchini, Michael; Pilat, Mary Jo; Uboha, Nataliya; Azad, Nilofer S; Cho, May; Davis, Elizabeth J; Ahnert, Jordi Rodon; Tinoco, Gabriel; Shapiro, Geoffrey I; Khagi, Simon; Powers, Benjamin; Spencer, Kristen; Groisberg, Roman; Drappatz, Jan; Chen, Li; Das,Bishu; Bao, Xun; Li, Jing; Narayan, Azeet; Vu, Dennis; Patel, Abhijit; Niger, Monica; Doroshow, Deborah; Durecki, Diane; Boerner, Scott A; Bindra, Ranjit; Ivy, Percy; Shyr, Derek; Shyr, Yu; LoRusso, Patricia M
  3. Cancer. 2025, Feb 15; 131(4): e35755.
  1. 10.   Drug-Linker Constructs Bearing Unique Dual-Mechanism Tubulin Binding Payloads Tethered through Cleavable and Non-Cleavable Linkers
  2. Ford, Jacob W; VanNatta, Jennifer M; Mondal, Deboprosad; Lin, Chen-Ming; Deng, Yuling; Bai, Ruoli; Hamel,Ernest; Trawick, Mary Lynn; Pinney, Kevin G
  3. Tetrahedron. 2025, Feb 01; 171
  1. 11.   Fine-tuning probes for fluorescence polarization binding assays of bivalent ligands against polo-like kinase 1 using full-length protein
  2. Tsuji, Kohei; Tamamura, Hirokazu; Burke,Terrence
  3. Bioorganic & Medicinal Chemistry . 2024, Dec 28; 119: 118055.
  1. 12.   The differential interactomes of the KRAS splice variants identify BIRC6 as a ubiquitin ligase for KRAS4A
  2. Kochen Rossi, Juan; Nuevo-Tapioles, Cristina; O'Keefe, Rachel A; Hunkeler, Moritz; Schmoker, Anna M; Fissore-O'Leary, Mercedes; Su, Wenjuan; Ahearn, Ian M; Branco, Cristina; Cheong, Hakyung; Esposito,Dom; Clotea, Ioana; Ueberheide, Beatrix; Fischer, Eric S; Philips, Mark R
  3. Cell Reports. 2024, Dec 19; 44(1): 115087.
  1. 13.   A randomised, placebo-controlled, phase III trial of leniolisib in activated phosphoinositide 3-kinase delta (PI3Kd) syndrome (APDS): Adolescent and adult subgroup analysis
  2. Rao, V Koneti; Šedivá, Anna; Dalm, Virgil A S H; Plebani, Alessandro; Schuetz, Catharina; Shcherbina, Anna; Trizzino, Antonino; Zharankova, Yulia; Orpia, Alanvin; Kulm,Elaine; Webster, Sharon; Körholz, Julia; Lougaris, Vassilios; Rodina, Yulia; Conlon, Niall; Coulter, Tanya; Bradt, Jason; Relan, Anurag; Uzel, Gulbu
  3. Clinical Immunology (Orlando, Fla.). 2024, Nov 17; 110400.
  1. 14.   Design, Synthesis and Biological Evaluation of 2-Phenyl Indole Analogues of OXi8006 as Colchicine Site Inhibitors of Tubulin Polymerization and Vascular Disrupting Agents
  2. Vairin, Rebecca; Tamminga, Caleb; Shi, Zhe; Borchardt, Christian; Jambulapati, Jayaram; Bai, Ruoli; Wanniarachchi, Hashini; Bueno, Lorena; Hamel,Ernest; Mason, Ralph P; Trawick, Mary Lynn; Pinney, Kevin G
  3. Bioorganic & Medicinal Chemistry. 2024, Nov 07; 118: 117981.
  1. 15.   Bisubstrate inhibitors of 6-hydroxymethyl-7,8-dihydroptein pyrophosphokinase: Toward cell permeability
  2. Shi,Genbin; Shaw,Gary; Ji,Xinhua
  3. Bioorganic & Medicinal Chemistry Letters. 2024, Sep 25; 129977.
  1. 16.   MoMo30 Binds to SARS-CoV-2 Spike Variants and Blocks Infection by SARS-CoV-2 Pseudovirus
  2. DeBarros, Kenya; Khan, Mahfuz; Coleman, Morgan; Bond, Vincent C; Floyd, Virginia; Gbodossou, Erick; Diop, Amad; Krumpe,Lauren; O'Keefe,Barry; Powell, Michael D
  3. Viruses. 2024, Sep 07; 16(9):
  1. 17.   Novel Arf1 Inhibitors Drive Cancer Stem Cell Aging and Potentiate Anti-Tumor Immunity
  2. Wang, Yuetong; Li, Qiaoming; Ding, Yahui; Luo, Chenfei; Yang, Jun; Wang, Na; Jiang, Ning; Yao, Tiange; Wang, Guohao; Shi, Guoming; Hou, Steven X
  3. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). 2024, Sep 03; e2404442.
  1. 18.   Guanylate-binding protein 5 antagonizes viral glycoproteins independently of furin processing
  2. Veler,Hana; Lun, Cheng Man; Waheed,Abdul; Freed,Eric
  3. mBio. 2024, Aug 30; e0208624.
  1. 19.   The SRC family kinase inhibitor NXP900 demonstrates potent anti-tumor activity in squamous cell carcinomas
  2. Dash,Sweta; Hanson, Sabrina; King, Ben; Nyswaner, Katherine; Foss, Kelcie; Tesi,Noelle; Harvey, Mungo J B; Navarro-Marchal, Saúl A; Woods, Allison; Poradosu, Enrique; Unciti-Broceta, Asier; Carragher, Neil O; Brognard,John
  3. The Journal of Biological Chemistry. 2024, Jul 30; 107615.
  1. 20.   Synthesis and Biological Evaluation of Novel 2-Aroyl Benzofuran-Based Hydroxamic Acids as Antimicrotubule Agents
  2. Mariotto, Elena; Canton, Martina; Marchioro, Chiara; Brancale, Andrea; Hamel,Ernest; Varani, Katia; Vincenzi, Fabrizio; De Ventura, Tiziano; Padroni, Chiara; Viola, Giampietro; Romagnoli, Romeo
  3. International Journal of Molecular Sciences. 2024, Jul 09; 25(14):
  1. 21.   Second-generation checkpoint inhibitors and Treg depletion synergize with a mouse cancer vaccine in accordance with tumor microenvironment characterization
  2. Becker, William; Olkhanud, Purevdorj B; Seishima, Noriko; Moreno, Paloma A; Goldfarbmuren,Kate; Maeng, Hoyoung M; Berzofsky, Jay A
  3. Journal for Immunotherapy of Cancer. 2024, Jul 01; 12(7):
  1. 22.   Slower CDK4 and faster CDK2 activation in the cell cycle
  2. Zhang,Wengang; Liu,Yonglan; Jang,Hyunbum; Nussinov,Ruth
  3. Structure (London, England : 1993). 2024, Apr 23;
  1. 23.   Metabolism-focused CRISPR screen unveils mitochondrial pyruvate carrier 1 as a critical driver for PARP inhibitor resistance in lung cancer
  2. Furusawa, Takashi; Cavero, Renzo; Liu, Yue; Li, Haojian; Xu,Xia; Andresson,Thorkell; Reinhold, William; White, Olivia; Boufraqech, Myriem; Meyer,Thomas; Hartmann, Oliver; Diefenbacher, Markus E; Pommier, Yves; Weyemi, Urbain
  3. Molecular Carcinogenesis. 2024, Feb 27;
  1. 24.   Inhibition of Plasmodium falciparum plasmepsins by drugs targeting HIV-1 protease: A way forward for antimalarial drug discovery
  2. Mishra, Vandana; Deshmukh, Anuradha; Rathore, Ishan; Chakraborty, Satadru; Patankar, Swati; Gustchina,Alla; Wlodawer,Alexander; Yada, Rickey Y; Bhaumik, Prasenjit
  3. Current Research in Structural Biology. 2024, Jan 17; 7: 100128.
  1. 25.   Revealing the mechanism of action of a first-in-class covalent inhibitor of KRASG12C (ON) and other functional properties of oncogenic KRAS by 31P NMR
  2. Sharma,Alok; Pei, Jun; Yang, Yue; Dyba,Marcin; Smith,Brian; Rabara,Dana; Larsen,Erik; Lightstone, Felice C; Esposito,Dom; Stephen,Andy; Wang, Bin; Beltran, Pedro J; Wallace, Eli; Nissley,Dwight; McCormick, Frank; Maciag,Anna
  3. The Journal of Biological Chemistry. 2024, Jan 16; 300(2): 105650.
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