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  1. 1.   Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine
  2. Maciag,Anna; Yang, Yue; Sharma,Alok; Turner,David; Dehart,Caroline; Abdelkarim, Hazem; Fan,Lixin; Smith,Brian; Kumari,Vandana; Dyba,Marcin; Rigby,Megan; Castillo Badillo,Jean; Adams, Lauren; Fornelli, Luca; Fox, Stephen; Brafman, Alla; Turbyville,Thomas; Gillette,William; Messing,Simon; Agamasu, Constance; Wolfe, Andrew L; Gysin, Stephan; Chan, Albert H; Simanshu,Dhirendra; Esposito,Dominic; Chertov,Oleg; Stephen,Andrew; Arkin, Michelle; Renslo, Adam; Kelleher, Neil L; Gaponenko, Vadim; Lightstone, Felice C; Nissley,Dwight; McCormick, Frank
  3. Proceedings of the National Academy of Sciences of the United States of America. 2025, May 13; 122(19): e2410766122.
  1. 2.   The differential interactomes of the KRAS splice variants identify BIRC6 as a ubiquitin ligase for KRAS4A
  2. Kochen Rossi, Juan; Nuevo-Tapioles, Cristina; O'Keefe, Rachel A; Hunkeler, Moritz; Schmoker, Anna M; Fissore-O'Leary, Mercedes; Su, Wenjuan; Ahearn, Ian M; Branco, Cristina; Cheong, Hakyung; Esposito,Dom; Clotea, Ioana; Ueberheide, Beatrix; Fischer, Eric S; Philips, Mark R
  3. Cell Reports. 2024, Dec 19; 44(1): 115087.
  1. 3.   Producing recombinant proteins in Vibrio natriegens
  2. Smith,Matthew; Hernández, José Sánchez; Messing,Simon; Ramakrishnan,Nitya; Higgins,Brianna; Mehalko,Jennifer; Perkins,Shelley; Wall,Vanessa; Grose,Carissa; Frank,Peter; Cregger, Julia; Le,Vi; Johnson,Adam; Sherekar, Mukul; Pagonis,Morgan; Drew,Matt; Hong,Min; Widmeyer, Stephanie R T; Denson,John-Paul; Snead,Kelly; Poon,Ivy; Waybright,Tim; Champagne, Allison; Esposito,Dom; Jones,Jane; Taylor,Troy; Gillette,Bill
  3. Microbial Cell Factories. 2024, Jul 24; 23(1): 208.
  1. 4.   Revealing the mechanism of action of a first-in-class covalent inhibitor of KRASG12C (ON) and other functional properties of oncogenic KRAS by 31P NMR
  2. Sharma,Alok; Pei, Jun; Yang, Yue; Dyba,Marcin; Smith,Brian; Rabara,Dana; Larsen,Erik; Lightstone, Felice C; Esposito,Dom; Stephen,Andy; Wang, Bin; Beltran, Pedro J; Wallace, Eli; Nissley,Dwight; McCormick, Frank; Maciag,Anna
  3. The Journal of Biological Chemistry. 2024, Jan 16; 300(2): 105650.
  1. 5.   Revealing KRas4b topology on the membrane surface
  2. Shree, Shweta; McLean, Mark A; Stephen,Andy; Sligar, Stephen G
  3. Biochemical and Biophysical Research Communications. 2023, Oct 20; 678: 122-127.
  1. 6.   Target-Specific Nanoparticle Polyplex Down-Regulates Mutant Kras to Prevent Pancreatic Carcinogenesis and Halt Tumor Progression
  2. Smith, Jill P; Chen, Wenqiang; Shivapurkar, Narayan; Gerber, Monica; Tucker, Robin D; Kallakury, Bhaskar; Dasa, Siva Sai Krishna; Kularatne,Ruvanthi Nilanga; Stern,Steve
  3. International Journal of Molecular Sciences. 2023, Jan 01; 24(1):
  1. 7.   Mapping the KRAS Proteoform Landscape in Colorectal Cancer Identifies Truncated KRAS4B that Decreases MAPK Signaling
  2. Adams, Lauren M; Dehart,Caroline; Drown, Bryon S; Anderson, Lissa C; Bocik,William; Boja, Emily S; Hiltke, Tara M; Hendrickson, Christopher L; Rodriguez, Henry; Caldwell, Michael; Vafabakhsh, Reza; Kelleher, Neil L
  3. The Journal of Biological Chemistry. 2022, Dec 02; 299(1): 102768.
  1. 8.   Thermal Shift Assay for Small GTPase Stability Screening: Evaluation and Suitability
  2. Kopra, Kari; Valtonen, Salla; Mahran, Randa; Kapp, Jonas N; Hassan, Nazia; Gillette,Bill; Dennis, Bryce; Li, Lianbo; Westover, Kenneth D; Plückthun, Andreas; Härmä, Harri
  3. International Journal of Molecular Sciences. 2022, Jun 26; 23(13):
  1. 9.   The dynamic nature of the K-Ras/calmodulin complex can be altered by oncogenic mutations
  2. Abdelkarim, Hazem; Leschinsky, Nicholas; Jang, Hyunbum; Banerjee, Avik; Nussinov,Ruth; Gaponenko, Vadim
  3. Current Opinion in Structural Biology. 2021, Dec; 71: 164-170.
  1. 10.   Mechanism of activation and the rewired network: New drug design concepts
  2. Nussinov,Ruth; Zhang,Mingzhen; Maloney, Ryan; Tsai,Chung-Jung; Yavuz, Bengi Ruken; Tuncbag, Nurcan; Jang, Hyunbum
  3. Medicinal research reviews. 2021, Oct 25; 0198-6325:
  1. 11.   NMR H-1, C-13, N-15 backbone resonance assignments of the T35S and oncogenic T35S/Q61L mutants of human KRAS4b in the active, GppNHp-bound conformation
  2. Sharma, Alok K.; Dyba, Marcin; Tonelli, Marco; Smith, Brian; Gillette, William K.; Esposito, Dominic; Nissley, Dwight; McCormick, Frank; Maciag, Anna E.
  3. Biomolecular NMR Assignments. 2021, Oct 22;
  1. 12.   RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity
  2. Castel, Pau; Dharmaiah,Sathiya; Sale, Matthew J; Messing,Simon; Rizzuto, Gabrielle; Cuevas-Navarro, Antonio; Cheng, Alice; Trnka, Michael J; Urisman, Anatoly; Esposito,Dom; Simanshu,Dhirendra; McCormick, Frank
  3. Proceedings of the National Academy of Sciences of the United States of America. 2021, Aug 17; 118(33):
  1. 13.   Sensitivity of Oncogenic KRAS-Expressing Cells to CDK9 Inhibition
  2. Lai, Lick Pui; Brel, Viviane; Sharma, Kanika; Frappier, Julia; Le-Henanf, Nadia; Vivet, Bertrand; Muzet, Nicolas; Schell, Emilie; Morales, Renaud; Rooney, Eamonn; Basse, Nicolas; Yi,Ming; Lacroix, Frederic; Holderfield, Matthew; Englaro, Walter; Marcireau, Christophe; Debussche, Laurent; Nissley,Dwight; McCormick, Frank
  3. SLAS DISCOVERY. 2021, Apr 24; 26(7, SI): 922-932.
  1. 14.   Unveiling the Dynamics of KRAS4b on Lipid Model Membranes
  2. Lopez, Cesar A.; Agarwal, Animesh; Van,Que; Stephen,Andy; Gnanakaran, S.
  3. Journal of Membrane Biology. 2021, Apr; 254(2): 201-216.
  1. 15.   The metabolic landscape of RAS-driven cancers from biology to therapy
  2. Mukhopadhyay,Suman; Vander Heiden, Matthew G.; McCormick, Frank
  3. Nature Cancer. 2021, Mar; 2(3): 271-283.
  1. 16.   The KRAS and other prenylated polybasic domain membrane anchors recognize phosphatidylserine acyl chain structure
  2. Zhou, Yong; Prakash, Priyanka S.; Liang, Hong; Gorfe, Alemayehu A.; Hancock, John F.
  3. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021, Feb 9; 118(6):
  1. 17.   Active and Inactive Cdc42 Differ in Their Insert Region Conformational Dynamics
  2. Haspel, Nurit; Jang,Hyunbum; Nussinov,Ruth
  3. Biophysical journal. 2021, Jan 19; 120(2): 306-318.
  1. 18.   Uncovering a membrane-distal conformation of KRAS available to recruit RAF to the plasma membrane
  2. Van,Que; López, Cesar A; Tonelli, Marco; Taylor,Troy; Niu, Ben; Stanley, Christopher B; Bhowmik, Debsindhu; Tran,Tim; Frank,Peter; Messing,Simon; Alexander,Patrick; Scott, Daniel; Ye, Xiaoying; Drew,Matt; Chertov,Oleg; Lösche, Mathias; Ramanathan, Arvind; Gross, Michael L; Hengartner, Nicolas W; Westler, William M; Markley, John L; Simanshu,Dhirendra; Nissley,Dwight; Gillette, William K; Esposito,Dom; McCormick, Frank; Gnanakaran, S; Heinrich, Frank; Stephen, Andrew G
  3. Proceedings of the National Academy of Sciences of the United States of America. 2020, SEP 29; 117(39): 24258-24268.
  1. 19.   The frequency of Ras mutations in cancer
  2. Prior, Ian A; Hood, Fiona E; Hartley,Jim
  3. Cancer research. 2020, JUL 15; 80(14): 2969-2974.
  1. 20.   Nucleotide-Specific Autoinhibition of Full-Length K-Ras4B Identified by Extensive Conformational Sampling
  2. Dudas, Balint; Merzel, Franci; Jang,Hyunbum; Nussinov,Ruth; Perahia, David; Balog, Erika
  3. Frontiers in molecular biosciences. 2020, JUL 10; 7: 145.
  1. 21.   The protein kinase MAP3K19 phosphorylates MAP2Ks and thereby activates ERK and JNK kinases and increases viability of KRAS-mutant lung cancer cells
  2. Hoang, Van T.; Nyswaner,Katherine; Torres-Ayuso,Pedro; Brognard,John
  3. JOURNAL OF BIOLOGICAL CHEMISTRY. 2020, JUN 19; 295(25): 8470-8479.
  1. 22.   The quaternary assembly of KRas4B with Raf-1 at the membrane
  2. Jang,Hyunbum; Zhang,Mingzhen; Nussinov,Ruth
  3. Computational and Structural Biotechnology Journal. 2020, Mar 25; 18: 737-748.
  1. 23.   Biochemical and structural analyses reveal that the tumor suppressor neurofibromin (NF1) forms a high-affinity dimer
  2. Sherekar,Mukul; Han, Sae-Won; Ghirlando, Rodolfo; Messing,Simon; Drew,Matt; Rabara,Dana; Waybright,Tim; Juneja, Puneet; O'Neill, Hugh; Stanley, Christopher B; Bhowmik, Debsindhu; Ramanathan, Arvind; Subramaniam,Sriram; Nissley,Dwight; Gillette,Bill; McCormick, Frank; Esposito,Dom
  3. The Journal of biological chemistry. 2020, JAN 24; 295(4): 1105-1119.
  1. 24.   Does Ras Activate Raf and PI3K Allosterically?
  2. Nussinov,Ruth; Tsai,Chung-Jung; Jang,Hyunbum
  3. Frontiers in oncology. 2019, Nov 15; 9
  1. 25.   The Structural Basis of the Farnesylated and Methylated KRas4B Interaction with Calmodulin
  2. Jang,Hyunbum; Banerjee, Avik; Marcus, Kendra; Makowski, Lee; Mattos, Carla; Gaponenko, Vadim; Nussinov,Ruth
  3. Structure (London, England : 1993). 2019, Nov 5; 27(11): 1647-1659.e4.
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