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  1. 1.   Phase 1 studies of the indenoisoquinolines LMP776 and LMP744 in patients with solid tumors and lymphomas
  2. O'Sullivan Coyne, Geraldine; Kummar, Shivaani; Rubinstein, Larry V; Wilsker,Deborah; Moore, Nancy; Hogu, Murielle; Piekarz, Richard; Covey, Joe; Beumer, Jan H; Ferry-Galow,Katherine; Villaruz, Liza C; Hollingshead,Melinda; Holleran, Julianne L; Deppas, Joshua J; Pommier, Yves; Ko, Brian; Johnson, Barry C; Parchhment, Ralph E; Ivy, Percy; Doroshow, James H; Chen, Alice P
  3. Cancer Chemotherapy and Pharmacology. 2025, May 29; 95(1): 58.
  1. 2.   A phase 1 and pharmacodynamic study of chronically-dosed, single-agent veliparib (ABT-888) in patients with BRCA1- or BRCA2-mutated cancer or platinum-refractory ovarian or triple-negative breast cancer
  2. Manzo, Julia; Puhalla, Shannon; Pahuja, Shalu; Ding, Fei; Lin, Yan; Appleman, Leonard; Tawbi, Hussein; Stoller, Ronald; Lee, James J; Diergaarde, Brenda; Kiesel, Brian F; Yu, Jing; Tan, Antoinette R; Belani, Chandra P; Chew, Helen; Garcia, Agustin A; Morgan, Robert J; Wahner Hendrickson, Andrea E; Visscher, Daniel W; Hurley, Rachel M; Kaufmann, Scott H; Swisher, Elizabeth M; Oesterreich, Steffi; Katz, Tiffany; Ji,Jay; Zhang, Yiping; Parchment, Ralph E; Chen, Alice; Duan, Wenrui; Giranda, Vincent; Shepherd, Stacie P; Ivy, S Percy; Chu, Edward; Beumer, Jan H
  3. Cancer Chemotherapy and Pharmacology. 2022, Apr 18; 89(5): 721-735.
  1. 3.   Combination therapy with pazopanib and tivantinib modulates VEGF and c-MET levels in refractory advanced solid tumors
  2. Kummar, Shivaani; Srivastava,Apurva; Navas, Tony; Cecchi, Fabiola; Lee, Young H.; Bottaro, Donald P.; Park, Sook Ryun; Do, Khanh T.; Jeong, Woondong; Johnson, Barry C.; Voth, Andrea R.; Rubinstein, Larry; Wright, John J.; Parchment,Ralph; Doroshow, James H.; Chen, Alice P.
  3. Investigational new drugs. 2021, Jun 28;
  1. 4.   Phase I trial of TRC102 (methoxyamine HCl) in combination with temozolomide in patients with relapsed solid tumors and lymphomas
  2. Coyne, Geraldine O'Sullivan; Kummar, Shivaani; Meehan, Robert S; Do, Khanh; Collins, Jerry M; Anderson, Larry; Ishii, Kazusa; Takebe, Naoko; Zlott, Jennifer; Juwara,Lamin; Piekarz, Richard; Streicher, Howard; Sharon, Elad; Rubinstein, Larry; Voth,Andrea; Lozier, Jay; Dull,Angie; Wilsker,Deborah; Hinoue, Toshinori; Laird, Peter W; Ferry-Galow,Katherine; Kinders,Robert; Parchment,Ralph; Doroshow,Jim; Chen, Alice P
  3. Oncotarget. 2020, Nov 03; 11(44): 3959-3971.
  1. 5.   Identification of pharmacodynamic biomarkers and common molecular mechanisms of response to genotoxic agents in cancer cell lines
  2. Min, Dong-Joon; Zhao, Yingdong; Monks, Anne; Palmisano, Alida; Hose,Curtis; Teicher, Beverly A; Doroshow, James H; Simon, Richard M
  3. Cancer chemotherapy and pharmacology. 2019, OCT; 84(4): 771-780.
  1. 6.   Population Pharmacokinetics and Pharmacodynamics of Disulfiram on Inducing Latent HIV-1 Transcription in a Phase 2b Trial
  2. Lee, Sulggi A; Elliott, Julian H; McMahon, James; Hartogenesis, Wendy; Bumpus, Namandje N; Lifson, Jeffrey; Gorelick, Robert; Bacchetti, Peter; Deeks, Steven G; Lewin, Sharon R; Savic, Radojka M
  3. Clinical pharmacology and therapeutics. 2019, Mar; 105(3): 692-702.
  1. 7.   Pharmacokinetic evaluation of the PNC disassembler metarrestin in wild-type and Pdx1-Cre;LSL-Kras(G12D/+);Tp53(R172H/+) (KPC) mice, a genetically engineered model of pancreatic cancer
  2. Vilimas, Tomas; Wang, Amy Q.; Patnaik, Samarjit; Hughes, Emma A.; Singleton, Marc D.; Knotts, Zachary; Li, Dandan; Frankowski, Kevin; Schlomer, Jerome; Guerin, Theresa; Springer, Stephanie; Drennan, Catherine; Dextras, Christopher; Wang, Chen; Gilbert, Debra; Southall, Noel; Ferrer, Marc; Huang, Sui; Kozlov, Serguei; Marugan, Juan; Xu, Xin; Rudloff, Udo
  3. CANCER CHEMOTHERAPY AND PHARMACOLOGY. 2018, Dec; 82(6): 1067-1080.
  1. 8.   Development of a quantitative pharmacodynamic assay for apoptosis in fixed tumor tissue and its application in distinguishing cytotoxic drug-induced DNA double strand breaks from DNA double strand breaks associated with apoptosis
  2. Dull, Angie; Wilsker, Deborah; Hollingshead, Melinda; Mazcko, Christina; Annunziata, Christina M; LeBlanc, Amy K; Doroshow, James H; Kinders, Robert; Parchment, Ralph
  3. Oncotarget. 2018, Mar 30; 9(24): 17104-17116.
  1. 9.   Differential Influence of the Antiretroviral Pharmacokinetic Enhancers Ritonavir and Cobicistat on Intestinal P-Glycoprotein Transport and the Pharmacokinetic/Pharmacodynamic Disposition of Dabigatran
  2. Kumar, Parag; Gordon, Lori A.; Brooks, Kristina M.; George, Jomy M.; Kellogg, Anela; McManus, Maryellen; Alfaro, Raul M.; Nghiem, Khanh; Lozier, Jay; Hadigan, Colleen; Penzak, Scott R.
  3. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2017, NOV; 61(11):
  1. 10.   Utility of F-18-fluoroestradiol (F-18-FES) PET/CT imaging as a pharmacodynamic marker in patients with refractory estrogen receptor-positive solid tumors receiving Z-endoxifen therapy
  2. Lin, F. I.; Gonzalez, E. M.; Kummar, S.; Do, K.; Shih, J.; Adler, Stephen; Kurdziel, K. A.; Ton, A.; Turkbey, B.; Jacobs, P. M.; Bhattacharyya, S.; Chen, A. P.; Collins, J. M.; Doroshow, J. H.; Choyke, P. L.; Lindenberg, M. L.
  3. European Journal of Nuclear Medicine and Molecular Imaging. 2017, Mar; 44(3): 500-508.
  1. 11.   Antiretroviral Boosting Agent Cobicistat Increases the Pharmacokinetic Exposure and Anticoagulant Effect of Dabigatran in HIV-Negative Healthy Volunteers.
  2. Gordon, Lori A; Kumar, Parag; Brooks, Kristina M; Kellogg, Anela; McManus, Maryellen; Alfaro, Raul M; Nghiem, Khanh; George, Jomy M; Lozier, Jay; Penzak, Scott R; Hadigan, Colleen
  3. Circulation. 2016, Dec 6; 134(23): 1909-1911.
  1. 12.   Promise and limits of the CellSearch platform for evaluating pharmacodynamics in circulating tumor cells
  2. Wang, L.; Balasubramanian, P.; Chen, A. P.; Kummar, S.; Evrard, Y. A.; Kinders, R. J.
  3. Seminars in Oncology. 2016, Aug; 43(4): 464-75.
  1. 13.   Establishing proof of mechanism: Assessing target modulation in early-phase clinical trials
  2. Kummar, S.; Do, K.; Coyne, G. O.; Chen, A.; Ji, J.; Rubinstein, L.; Doroshow, J. H.
  3. Seminars in Oncology. 2016, Aug; 43(4): 446-52.
  1. 14.   The statistics of phase 0 trials
  2. Rubinstein, L. V.; Steinberg, S. M.; Kummar, S.; Kinders, R.; Parchment, R. E.; Murgo, A. J.; Tomaszewski, J. E.; Doroshow, J. H.
  3. Statistics in Medicine. 2010, May; 29(10): 1072-1076.
  1. 15.   Phase 0 clinical trials: Conceptions and misconceptions
  2. Kummar, S.; Rubinstein, L.; Kinders, R.; Parchment, R. E.; Gutierrez, M. E.; Murgo, A. J.; Ji, J.; Mroczkowski, B.; Pickeral, O. K.; Simpson, M.; Hollingshead, M.; Yang, S. X.; Helman, L.; Wiltrout, R.; Collins, J.; Tomaszewski, J. E.; Doroshow, J. H.
  3. Cancer Journal. 2008 14(3): 133-137.
  1. 16.   Phase I trial of MS-275, a histone deacetylase inhibitor, administered weekly in refractory solid tumors and lymphoid malignancies
  2. Kummar, S.; Gutierrez, M.; Gardner, E. R.; Donovan, E.; Hwang, K.; Chung, E. J.; Lee, M. J.; Maynard, K.; Kalnitskiy, M.; Chen, A.; Melillo, G.; Ryan, Q. C.; Conley, B.; Figg, W. D.; Trepel, J. B.; Zwiebel, J.; Doroshow, J. H.; Murgo, A. J.
  3. Clinical Cancer Research. 2007, Sep; 13(18): 5411-5417.
  1. 17.   Pathogenesis of Aspergillus fumigatus and the kinetics of galactomannan in an in vitro model of early invasive pulmonary aspergillosis: Implications for antifungal therapy
  2. Hope, W. W.; Kruhlak, M. J.; Lyman, C. A.; Petraitiene, R.; Petraitis, V.; Francesconi, A.; Kasai, M.; Mickiene, D.; Sein, T.; Peter, J.; Kelaher, A. M.; Hughes, J. E.; Cotton, M. P.; Cotten, C. J.; Bacher, J.; Tripathi, S.; Bermudez, L.; Maugel, T. K.; Zerfas, P. M.; Wingard, J. R.; Drusano, G. L.; Walsh, T. J.
  3. Journal of Infectious Diseases. 2007, Feb; 195(3): 455-466.
  1. 18.   Lack of sex-related differences in saquinavir pharmacokinetics in an HIV-seronegative cohort
  2. Robertson, S. M.; Formentini, E.; Alfaro, R. M.; Natarajan, V.; Falloon, J.; Penzak, S. R.
  3. British Journal of Clinical Pharmacology. 2006, Apr; 61(4): 379-388.
  1. 19.   Novel Superiority Tests for Anti-Infective Drug Trials: Three Examples
  2. Brittain, Erica; Follmann, Dean; Joshi, Gyan
  3. Statistics in Biopharmaceutical Research. 2018 10(1): 9-17.
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