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  1. 1.   The antitumor drug candidate 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole induces NF-kappa B activity in drug-sensitive MCF-7 cells
  2. Brantley, E.; Patel, V.; Stinson, S. F.; Trapani, V.; Hose, C. D.; Ciolino, H. P.; Yeh, G. C.; Gutkind, J. S.; Sausville, E. A.; Loaiza-Perez, A. I.
  3. Anti-Cancer Drugs. 2005, FEB; 16(2): 137-143.
  1. 2.   Fluorinated 2-(4-amino-3-methylphenyl) benzothiazoles induce CYP1A1 expression, become metabolized, and bind to macromolecules in sensitive human cancer cells
  2. Brantley, E.; Trapani, V.; Alley, M. C.; Hose, C. D.; Bradshaw, T. D.; Stevens, M. F. G.; Sausville, E. A.; Stinson, S. F.
  3. Drug Metabolism and Disposition. 2004, DEC; 32(12): 1392-1401.
  1. 3.   The experimental antitumor agents Phortress and Doxorubicin are equiactive against human-derived breast carcinoma xenograft models
  2. Fichtner, I.; Monks, A.; Hose, C.; Stevens, M. F. G.; Bradshaw, T. D.
  3. Breast Cancer Research and Treatment. 2004, SEP; 87(1): 97-107.
  1. 4.   DNA damage and cell cycle arrest induced by 2-(4-amino-3- methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) is attenuated in aryl hydrocarbon receptor deficient MCF-7 cells
  2. Trapani, V.; Patel, V.; Leong, C. O.; Ciolino, H. P.; Yeh, G. C.; Hose, C.; Trepel, J. B.; Stevens, M. F. G.; Sausville, E. A.; Loaiza-Perez, A. I.
  3. British Journal of Cancer. 2003 88(4): 599-605.
  1. 5.   Genotoxic profiling of MCF-7 breast cancer cell line elucidates gene expression modifications underlying toxicity of the anticancer drug 2-(4-amino-3-methylphenyl)-5- fluorobenzothiazole
  2. Monks, A.; Harris, E.; Hose, C.; Connelly, J.; Sausville, E. A.
  3. Molecular Pharmacology. 2003 63(3): 766-772.
  1. 6.   Induction of CYP1A1 in tumor cells by the antitumor agent 2-[4- amino-3-methylphenyl]-5-fluoro-benzothiazole: A potential surrogate marker for patient sensitivity
  2. Hose, C. D.; Hollingshead, M.; Sausville, E. A.; Monks, A.
  3. Molecular Cancer Therapeutics. 2003 2(12): 1265-1272.
  1. 7.   Preclinical evaluation of amino acid Prodrugs of novel antitumor 2-(4-amino-3-methylphenyl)benzothiazoles
  2. Bradshaw, T. D.; Bibby, M. C.; Double, J. A.; Fichtner, I.; Cooper, P. A.; Alley, M. C.; Donohue, S.; Stinson, S. F.; Tomaszewjski, J. E.; Sausville, E. A.; Stevens, M. F. G.
  3. Molecular Cancer Therapeutics. 2002 1(4): 239-246.
  1. 8.   In vitro evaluation of amino acid prodrugs of novel antitumour 2-(4-amino-3-methylphenyl)benzothiazoles
  2. Bradshaw, T. D.; Chua, M. S.; Browne, H. L.; Trapani, V.; Sausville, E. A.; Stevens, M. F. G.
  3. British Journal of Cancer. 2002 86(8): 1348-1354.
  1. 9.   Aryl hydrocarbon receptor mediates sensitivity of MCF-7 breast cancer cells to antitumor agent 2-(4-amino-3-methylphenyl) benzothiazole
  2. Loaiza-Perez, A. I.; Trapani, V.; Hose, C.; Singh, S. S.; Trepel, J. B.; Stevens, M. F. G.; Bradshaw, T. D.; Sausville, E. A.
  3. Molecular Pharmacology. 2002 61(1): 13-19.
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