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  1. 1.   Isolation and structure elucidation of Dm-CVNH, a new cyanovirin-N homolog with activity against SARS-CoV-2 and HIV-1
  2. Orfanoudaki,Maria; Krumpe,Lauren; Shenoy, Shilpa R; Wilson,Jennifer; Guszczynski, Tad; Henrich,Curtis; Temme,Joel; Gildersleeve,Jeffrey; Molina-Molina, Elisa; Erkizia, Itziar; Blanco, Julià; Izquierdo-Useros, Nuria; Montiero, Fabio; Tanuri, Amilcar; Rech, Elibio; O'Keefe,Barry
  3. The Journal of Biological Chemistry. 2025, Feb 14; 108319.
  1. 2.   The lectins griffithsin, cyanovirin-N and scytovirin inhibit HIV-1 binding to the DC-SIGN receptor and transfer to CD4(+) cells
  2. Alexandre, K. B.; Gray, E. S.; Mufhandu, H.; McMahon, J. B.; Chakauya, E.; O'Keefe, B. R.; Chikwamba, R.; Morris, L.
  3. Virology. 2012, Feb; 423(2): 175-186.
  1. 3.   Investigation of Griffithsin's Interactions with Human Cells Confirms Its Outstanding Safety and Efficacy Profile as a Microbicide Candidate
  2. Kouokam, J. C.; Huskens, D.; Schols, D.; Johannemann, A.; Riedell, S. K.; Walter, W.; Walker, J. M.; Matoba, N.; O'Keefe, B. R.; Palmer, K. E.
  3. Plos One. 2011, Aug; 6(8):
  1. 4.   Anti-HIV microbicide development: targeting the virus is the key
  2. O'Keefe, B. R.
  3. Future Virology. 2011, May; 6(5): 553-556.
  1. 5.   Monomerization of Viral Entry Inhibitor Griffithsin Elucidates the Relationship between Multivalent Binding to Carbohydrates and anti-HIV Activity
  2. Moulaei, T.; Shenoy, S. R.; Giomarelli, B.; Thomas, C.; McMahon, J. B.; Dauter, Z.; O'Keefe, B. R.; Wlodawer, A.
  3. Structure. 2010, Sep; 18(9): 1104-1115.
  1. 6.   Mannose-rich glycosylation patterns on HIV-1 subtype C gp120 and sensitivity to the lectins, Griffithsin, Cyanovirin-N and Scytovirin
  2. Alexandre, K. B.; Gray, E. S.; Lambson, B. E.; Moore, P. L.; Choge, I. A.; Mlisana, K.; Karim, S. S. A.; McMahon, J.; O'Keefe, B.; Chikwamba, R.; Morris, L.
  3. Virology. 2010, Jun; 402(1): 187-196.
  1. 7.   Broad-Spectrum In Vitro Activity and In Vivo Efficacy of the Antiviral Protein Griffithsin against Emerging Viruses of the Family Coronaviridae
  2. O'Keefe, B. R.; Giomarelli, B.; Barnard, D. L.; Shenoy, S. R.; Chan, P. K. S.; McMahon, J. B.; Palmer, K. E.; Barnett, B. W.; Meyerholz, D. K.; Wohlford-Lenane, C. L.; McCray, P. B.
  3. Journal of Virology. 2010, Mar; 84(5): 2511-2521.
  1. 8.   Multivalent Interactions with gp120 Are Required for the Anti-HIV Activity of Cyanovirin
  2. Liu, Y. A.; Carroll, J. R.; Holt, L. A.; McMahon, J.; Giomarelli, B.; Ghirl, a
  3. Biopolymers. 2009 92(3): 194-200.
  1. 9.   Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component
  2. O'Keefe, B. R.; Vojdani, F.; Buffa, V.; Shattock, R. J.; Montefiori, D. C.; Bakke, J.; Mirsalis, J.; d'Andrea, A. L.; Hume, S. D.; Bratcher, B.; Saucedo, C. J.; McMahon, J. B.; Pogue, G. P.; Palmer, K. E.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2009 106(15): 6099-6104.
  1. 10.   Glycoside analogs of beta-galactosylceramide, a novel class of small molecule antiviral agents that inhibit HIV-1 entry
  2. Garg, H.; Francella, N.; Tony, K. A.; Augustine, L. A.; Barchi, J. J.; Fantini, J.; Puri, A.; Mootoo, D. R.; Blumenthal, R.
  3. Antiviral Research. 2008 80(1): 54-61.
  1. 11.   Treatment of influenza A (H1N1) virus infections in mice and ferrets with cyanovirin-N
  2. Smee, D. F.; Bailey, K. W.; Wong, M. H.; O'Keefe, B. R.; Gustafson, K. R.; Mishin, V. P.; Gubareva, L. V.
  3. Antiviral Research. 2008 80(3): 266-271.
  1. 12.   The novel fold of scytovirin reveals a new twist for antiviral entry inhibitors
  2. McFeeters, R. L.; Xiong, C. Y.; O'Keefe, B. R.; Bokesch, H. R.; McMahon, J. B.; Ratner, D. M.; Castelli, R.; Seeberger, P. H.; Byrd, R. A.
  3. Journal of Molecular Biology. 2007, Jun; 369(2): 451-461.
  1. 13.   Crystallographic, thermodynamic, and molecular modeling studies of the mode of binding of oligosaccharides to the potent antiviral protein griffithsin
  2. Ziolkowska, N. E.; Shenoy, S. R.; O'Keefe, B. R.; McMahon, J. B.; Palmer, K. E.; Dwek, R. A.; Wormald, M. R.; Wlodawer, A.
  3. Proteins-Structure Function and Bioinformatics. 2007, May; 67(3): 661-670.
  1. 14.   Potent anti-HIV activity of scytovirin domain 1 peptide
  2. Xiong, C. Y.; O'Keefe, B. R.; Byrd, R. A.; McMahon, J. B.
  3. Peptides. 2006, Jul; 27(7): 1668-1675.
  1. 15.   Domain-swapped structure of the potent antiviral protein griffithsin and its mode of carbohydrate binding
  2. Ziolkowska, N. E.; O'Keefe, B. R.; Mori, T.; Zhu, C.; Giomarelli, B.; Vojdani, F.; Palmer, K. E.; McMahon, J. B.; Wlodawer, A.
  3. Structure. 2006, Jul; 14(7): 1127-1135.
  1. 16.   Recombinant production of anti-HIV protein, griffithsin, by auto-induction in a fermentor culture
  2. Giomarelli, B.; Schumacher, K. M.; Taylor, T. E.; Sowder, R. C.; Hartley, J. L.; McMahon, J. B.; Mori, T.
  3. Protein Expression and Purification. 2006, MAY; 47(1): 194-202.
  1. 17.   Overexpression and purification of scytovirin, a potent, novel anti-HIV protein from the cultured cyanobacterium Scytonema varium
  2. Xiong, C. Y.; O'Keefe, B. R.; Botos, I.; Wlodawer, A.; McMahon, J. B.
  3. Protein Expression and Purification. 2006, Apr; 46(2): 233-239.
  1. 18.   Structural studies of algal lectins with anti-HIV activity
  2. Ziolkowska, N. E.; Wlodawer, A.
  3. Acta Biochimica Polonica. 2006 53(4): 617-626.
  1. 19.   Resistance of human immunodeficiency virus type 1 to the high-mannose binding agents cyanovirin N and concanavalin A
  2. Witvrouw, M.; Fikkert, V.; Hantson, A.; Pannecouque, C.; O'Keefe, B. R.; McMahon, J.; Stamatatos, L.; De Clercq, E.; Bolmstedt, A.
  3. Journal of Virology. 2005, JUN; 79(12): 7777-7784.
  1. 20.   Proteins that bind high-mannose sugars of the HIV envelope
  2. Botos, I.; Wlodawer, A.
  3. Progress in Biophysics and Molecular Biology. 2005, JUN; 88(2): 233-282.
  1. 21.   Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp
  2. Mori, T.; O'Keefe, B. R.; Sowder, R. C.; Bringans, S.; Gardella, R.; Berg, S.; Cochran, P.; Turpin, J. A.; Buckheit, R. W.; McMahon, J. B.; Boyd, M. R.
  3. Journal of Biological Chemistry. 2005, MAR 11; 280(10): 9345-9353.
  1. 22.   Novel strategies in HIV prevention-development of topical microbicides
  2. Beer, B. E.; Cummins, J. E.
  3. Annual Reports in Medicinal Chemistry, Vol 40. 2005; 40 : 277-290.
  1. 23.   Development of a fluorescent microplate assay for determining cyanovirin-N levels in plasma
  2. Bringans, S. D.; O'Keefe, B. R.; Bray, M.; Whitehouse, C. A.; Boyd, M. R.
  3. Analytical and Bioanalytical Chemistry. 2004, SEP; 380(2): 269-274.
  1. 24.   Probing protein-carbohydrate interactions with microarrays of synthetic oligosaccharides
  2. Ratner, D. M.; Adams, E. W.; Su, J.; O'Keefe, B. R.; Mrksich, M.; Seeberger, P. H.
  3. Chembiochem. 2004 5(3): 379-382.
  1. 25.   Cyanovirin-N inhibits AIDS virus infections in vaginal transmission models
  2. Tsai, C. C.; Emau, P.; Jiang, Y. H.; Agy, M. B.; Shattock, R. J.; Schmidt, A.; Morton, W. R.; Gustafson, K. R.; Boyd, M. R.
  3. Aids Research and Human Retroviruses. 2004 20(1): 11-18.
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