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  1. 1.   Allosteric modulation of NF1 GAP: Differential distributions of catalytically competent populations in loss-of-function and gain-of-function mutants
  2. Xu,Liang; Jang,Hyunbum; Nussinov,Ruth
  3. Protein Science : a publication of the Protein Society. 2025, Feb; 34(2): e70042.
  1. 3.   Phase II study of vemurafenib in children and young adults with tumors harboring BRAF V600 mutations: NCI-COG pediatric MATCH trial (APEC1621) Arm G
  2. Nelson, Marie V; Kim, AeRang; Williams,Mickey; Roy-Chowdhuri, Sinchita; Patton, David R; Coffey, Brent D; Reid, Joel M; Piao, Jin; Saguilig, Lauren; Alonzo, Todd A; Berg, Stacey L; Ramirez, Nilsa C; Jaju, Alok; Fox, Elizabeth; Weigel, Brenda J; Hawkins, Douglas S; Mooney, Margaret M; Takebe, Naoko; Tricoli, James V; Janeway, Katherine A; Seibel, Nita L; Parsons, D Williams
  3. The Oncologist. 2024, Jun 14;
  1. 4.   Cancer and Autism: How PTEN Mutations Degrade Function at the Membrane and Isoform Expression in the Human Brain
  2. Jang,Hyunbum; Chen, Jiaye; Iakoucheva, Lilia M; Nussinov,Ruth
  3. Journal of Molecular Biology. 2023, Dec 15; 435(24): 168354.
  1. 5.   Conformational Dynamics Allows Sampling of an "Active-like" State by Oncogenic K-Ras-GDP
  2. Grudzien, Patrick; Jang,Hyunbum; Leschinsky, Nicholas; Nussinov,Ruth; Gaponenko, Vadim
  3. Journal of Molecular Biology. 2022, Jun 22; 167695.
  1. 6.   Signaling in the crowded cell
  2. Nussinov,Ruth; Tsai,Chung-Jung; Jang,Hyunbum
  3. Current Opinion in Structural Biology. 2021, Dec; 71: 43-50.
  1. 7.   Mechanism of activation and the rewired network: New drug design concepts
  2. Nussinov,Ruth; Zhang,Mingzhen; Maloney, Ryan; Tsai,Chung-Jung; Yavuz, Bengi Ruken; Tuncbag, Nurcan; Jang, Hyunbum
  3. Medicinal research reviews. 2021, Oct 25; 0198-6325:
  1. 8.   SASH3 variants cause a novel form of X-linked combined immunodeficiency with immune dysregulation
  2. Delmonte, Ottavia M.; Bergerson, Jenna R. E.; Kawai, Tomoki; Kuehn, Hye Sun; McDermott, David H.; Cortese, Irene; Zimmermann, Michael T.; Dobbs, A. Kerry; Bosticardo, Marita; Fink,Dani; Majumdar, Shamik; Palterer, Boaz; Pala, Francesca; Dsouza, Nikita R.; Pouzolles, Marie; Taylor, Naomi; Calvo, Katherine R.; Daley, Stephen R.; Velez, Daniel; Agharahimi, Anahita; Myint-Hpu, Katherine; Dropulic, Lesia K.; Lyons, Jonathan J.; Holland, Steven M.; Freeman, Alexandra F.; Ghosh, Rajarshi; Similuk, Morgan B.; Niemela, Julie E.; Stoddard, Jennifer; Kuhns,Doug; Urrutia, Raul; Rosenzweig, Sergio D.; Walkiewicz, Magdalena A.; Murphy, Philip M.; Notarangelo, Luigi D.
  3. BLOOD. 2021, Sep 23; 138(12): 1019-1033.
  1. 9.   Proteogenomic characterization of pancreatic ductal adenocarcinoma
  2. Cao, Liwei; Huang, Chen; Zhou, Daniel Cui; Hu, Yingwei; Lih, T. Mamie; Savage, Sara R.; Krug, Karsten; Clark, David J.; Schnaubelt, Michael; Chen, Lijun; Leprevost, Felipe da Veiga; Eguez, Rodrigo Vargas; Yang, Weiming; Pan, Jianbo; Wen, Bo; Dou, Yongchao; Jiang, Wen; Liao, Yuxing; Shi, Zhiao; Terekhanova, Nadezhda; Cao, Song; Lu, Rita Jui-Hsien; Li, Yize; Liu, Ruiyang; Zhu, Houxiang; Ronning, Peter; Wu, Yige; Wyczalkowski, Matthew A.; Easwaran, Hariharan; Danilova, Ludmila; Mer, Arvind Singh; Yoo, Seungyeul; Wang, Joshua M.; Liu, Wenke; Haibe-Kains, Benjamin; Thiagarajan,Mathangi; Jewell, Scott D.; Hostetter, Galen; Newton, Chelsea J.; Li, Qing Kay; Roehr, Michael H.; Fenyo, David; Wang, Pei; Nesvizhskii, Alexey; Mani, D. R.; Omenn, Gilbert S.; Boja, Emily S.; Mesri, Mehdi; Robles, Ana; Rodriguez, Henry; Bathe, Oliver F.; Chan, Daniel W.; Hruban, Ralph H.; Ding, Li; Zhang, Bing; Zhang, Hui
  3. Cell. 2021, Sep 16; 184(19): 5031-5052.e26.
  1. 10.   Establishing community reference samples, data and call sets for benchmarking cancer mutation detection using whole-genome sequencing
  2. Fang, Li Tai; Zhu, Bin; Zhao,Yongmei; Chen, Wanqiu; Yang, Zhaowei; Kerrigan, Liz; Langenbach, Kurt; de Mars, Maryellen; Lu, Charles; Idler, Kenneth; Jacob, Howard; Zheng, Yuanting; Ren, Luyao; Yu, Ying; Jaeger, Erich; Schroth, Gary P.; Abaan, Ogan D.; Talsania,Keyur; Lack,Justin; Shen,Tsai-Wei; Chen, Zhong; Stanbouly, Seta; Tran,Bao; Shetty,Jyoti; Kriga,Yuliya; Meerzaman, Daoud; Nguyen, Cu; Petitjean, Virginie; Sultan, Marc; Cam, Margaret; Mehta,Monika; Hung, Tiffany; Peters, Eric; Kalamegham, Rasika; Sahraeian, Sayed Mohammad Ebrahim; Mohiyuddin, Marghoob; Guo, Yunfei; Yao, Lijing; Song, Lei; Lam, Hugo Y. K.; Drabek, Jiri; Vojta, Petr; Maestro, Roberta; Gasparotto, Daniela; Koks, Sulev; Reimann, Ene; Scherer, Andreas; Nordlund, Jessica; Liljedahl, Ulrika; Jensen, Roderick; Pirooznia, Mehdi; Li, Zhipan; Xiao, Chunlin; Sherry, Stephen T.; Kusko, Rebecca; Moos, Malcolm; Donaldson, Eric; Tezak, Zivana; Ning, Baitang; Tong, Weida; Li, Jing; Duerken-Hughes, Penelope; Catalanotti, Claudia; Maheshwari, Shamoni; Shuga, Joe; Liang, Winnie S.; Keats, Jonathan; Adkins, Jonathan; Tassone, Erica; Zismann, Victoria; McDaniel, Timothy; Trent, Jeffrey; Foox, Jonathan; Butler, Daniel; Mason, Christopher E.; Hong, Huixiao; Shi, Leming; Wang, Charles; Xiao, Wenming
  3. Nature biotechnology. 2021, Sep; 39(9): 1151-1160.
  1. 11.   Toward best practice in cancer mutation detection with whole-genome and whole-exome sequencing
  2. Xiao, Wenming; Ren, Luyao; Chen, Zhong; Fang, Li Tai; Zhao,Yongmei; Lack,Justin; Guan, Meijian; Zhu, Bin; Jaeger, Erich; Kerrigan, Liz; Blomquist, Thomas M.; Hung, Tiffany; Sultan, Marc; Idler, Kenneth; Lu, Charles; Scherer, Andreas; Kusko, Rebecca; Moos, Malcolm; Xiao, Chunlin; Sherry, Stephen T.; Abaan, Ogan D.; Chen, Wanqiu; Chen, Xin; Nordlund, Jessica; Liljedahl, Ulrika; Maestro, Roberta; Polano, Maurizio; Drabek, Jiri; Vojta, Petr; Koks, Sulev; Reimann, Ene; Madala, Bindu Swapna; Mercer, Timothy; Miller, Chris; Jacob, Howard; Truong, Tiffany; Moshrefi, Ali; Natarajan, Aparna; Granat, Ana; Schroth, Gary P.; Kalamegham, Rasika; Peters, Eric; Petitjean, Virginie; Walton,Ashley; Shen,Tsai-Wei; Talsania,Keyur; Vera, Cristobal Juan; Langenbach, Kurt; de Mars, Maryellen; Hipp, Jennifer A.; Willey, James C.; Wang, Jing; Shetty,Jyoti; Kriga,Yuliya; Raziuddin,Arati; Tran,Bao; Zheng, Yuanting; Yu, Ying; Cam, Margaret; Jailwala, Parthav; Meerzaman, Daoud; Chen, Qingrong; Yan, Chunhua; Ernest, Ben; Mehra, Urvashi; Jensen, Roderick; Jones, Wendell; Li, Jian-Liang; Papas, Brian N.; Pirooznia, Mehdi; Chen, Yun-Ching; Seifuddin, Fayaz; Li, Zhipan; Liu, Xuelu; Resch, Wolfgang; Wang, Jingya; Wu, Leihong; Yavas, Gokhan; Miles, Corey; Ning, Baitang; Tong, Weida; Mason, Christopher E.; Donaldson, Eric; Lababidi, Samir; Staudt, Louis M.; Tezak, Zivana; Hong, Huixiao; Wang, Charles; Shi, Leming
  3. Nature Biotechnology. 2021, Sep; 39(9): 1141-1150.
  1. 12.   Pathogenic germline IKZF1 variant alters hematopoietic gene expression profiles
  2. Brodie,Seth; Khincha, Payal P.; Giri, Neelam; Bouk,Aaron; Steinberg,Mia; Dai,Jieqiong; Jessop, Lea; Donovan, Frank X.; Chandrasekharappa, Settara C.; de Andrade, Kelvin C.; Maric, Irina; Ellis, Steven R.; Mirabello, Lisa; Alter, Blanche P.; Savage, Sharon A.
  3. COLD SPRING HARBOR MOLECULAR CASE STUDIES. 2021, AUG; 7(4):
  1. 13.   Drugging multiple same-allele driver mutations in cancer
  2. Nussinov,Ruth; Zhang,Mingzhen; Maloney,Ryan; Jang, Hyunbum
  3. Expert Opinion on Drug Discovery. 2021, Aug; 16(8): 823-828.
  1. 14.   Novel HOXD13 variants in syndactyly type 1b and type 1c, and a new spectrum of TP63-related disorders
  2. Patel,Rashmi; Singh, Subodh Kumar; Bhattacharya, Visweswar; Ali, Akhtar
  3. Journal of human genetics. 2021, Jul 28;
  1. 15.   TRIM37 prevents formation of condensate-organized ectopic spindle poles to ensure mitotic fidelity
  2. Meitinger, Franz; Kong,Dong; Ohta, Midori; Desai, Arshad; Oegema, Karen; Loncarek,Jadranka
  3. The Journal of Cell Biology. 2021, Jul 5; 220(7):
  1. 16.   The dystonia gene THAP1 controls DNA double-strand break repair choice
  2. Shinoda, Kenta; Zong, Dali; Callen, Elsa; Wu, Wei; Dumitrache, Lavinia C.; Belinky, Frida; Chari,Raj; Wong, Nancy; Ishikawa, Momoko; Stanlie, Andre; Multhaupt-Buell, Trisha; Sharma, Nutan; Ozelius, Laurie; Ehrlich, Michelle; McKinnon, Peter J.; Nussenzweig, Andre
  3. MOLECULAR CELL. 2021, Jun 17; 81(12): 2611-2624.e10.
  1. 17.   Differential Outcomes in Codon 12/13 and Codon 61 NRAS-Mutated Cancers in the Phase II NCI-MATCH Trial of Binimetinib in Patients with NRAS-Mutated Tumors
  2. Cleary, James M.; Wang, Victoria; Heist, Rebecca S.; Kopetz, E. Scott; Mitchell, Edith P.; Zwiebel, James A.; Kapner, Kevin S.; Chen, Helen X.; Li, Shuli; Gray, Robert J.; McShane, Lisa M.; Rubinstein, Larry V.; Patton, David R.; Meric-Bernstam, Funda; Dillmon, Melissa S.; Williams,Mickey; Hamilton, Stanley R.; Conley, Barbara A.; Aguirre, Andrew J.; O'Dwyer, Peter J.; Harris, Lyndsay N.; Arteaga, Carlos L.; Chen, Alice P.; Flaherty, Keith T.
  3. Clinical cancer research : an official journal of the American Association for Cancer Research. 2021, Jun 1; 27(11): 2996-3004.
  1. 18.   Normal Mode Analysis of KRas4B Reveals Partner Specific Dynamics
  2. Eren, Meryem; Tuncbag, Nurcan; Jang,Hyunbum; Nussinov,Ruth; Gursoy, Attila; Keskin, Ozlem
  3. The journal of physical chemistry. B. 2021, May 27; 125(20): 5210-5221.
  1. 19.   TET2 and DNMT3A mutations and exceptional response to 4'-thio-2'-deoxycytidine in human solid tumor models
  2. Yang, Sherry X; Hollingshead, Melinda; Rubinstein, Larry; Nguyen, Dat; Larenjeira, Angelo B A; Kinders,Robert; Difilippantonio, Michael; Doroshow, James H
  3. Journal of Hematology & Oncology. 2021, May 26; 14(1):
  1. 20.   Lack of transgenerational effects of ionizing radiation exposure from the Chernobyl accident
  2. Yeager,Meredith; Machiela, Mitchell J.; Kothiya, Prachi; Dean,Michael; Bodelon, Clara; Suman, Shalabh; Wang,Mingyi; Mirabello, Lisa; Nelson, Chase W.; Zhou,Weiyin; Palmer, Cameron; Ballew, Bari; Colli, Leandro M.; Freedman, Neal D.; Dagnall,Casey; Hutchinson,Amy; Vij, Vibha; Maruvka, Yosi; Hatch, Maureen; Illienko, Iryna; Belayev, Yuri; Nakamura, Nori; Chumak, Vadim; Bakhanova, Elena; Belyi, David; Kryuchkov, Victor; Golovanov, Ivan; Gudzenko, Natalia; Cahoon, Elizabeth K.; Albert, Paul; Drozdovitch, Vladimir; Little, Mark P.; Mabuchi, Kiyohiko; Stewart, Chip; Getz, Gad; Bazyka, Dimitry; de Gonzalez, Amy Berrington; Chanock, Stephen J.
  3. Science (New York, N.Y.). 2021, May 14; 372(6543): 725-729.
  1. 21.   Immunodeficiency and bone marrow failure with mosaic and germline TLR8 gain of function
  2. Aluri, Jahnavi; Bach, Alicia; Kaviany, Saara; Paracatu, Luana Chiquetto; Kitcharoensakkul, Maleewan; Walkiewicz, Magdalena A.; Putnam, Christopher D.; Shinawi, Marwan; Saucier, Nermina; Rizzi, Elise M.; Harmon, Michael T.; Keppel, Molly P.; Ritter, Michelle; Similuk, Morgan; Kulm,Elaine; Joyce, Michael; de Jesus, Adriana A.; Goldbach-Mansky, Raphaela; Lee, Yi-Shan; Cella, Marina; Kendall, Peggy L.; Dinauer, Mary C.; Bednarski, Jeffrey J.; Bemrich-Stolz, Christina; Canna, Scott W.; Abraham, Shirley M.; Demczko, Matthew M.; Powell, Jonathan; Jones, Stacie M.; Scurlock, Amy M.; De Ravin, Suk See; Bleesing, Jack J.; Connelly, James A.; Rao, V. Koneti; Schuettpelz, Laura G.; Cooper, Megan A.
  3. Blood. 2021, May 6; 137(18): 2450-2462.
  1. 22.   CD225 Proteins: A Family Portrait of Fusion Regulators
  2. Coomer, Charles A.; Rahman,Kazi; Compton,Alex
  3. Trends in Genetics. 2021, May; 37(5): 406-410.
  1. 23.   Mechanistic Differences of Activation of Rac1(P29S) and Rac1(A159V)
  2. Senyuz, Simge; Jang,Hyunbum; Nussinov,Ruth; Keskin, Ozlem; Gursoy, Attila
  3. Journal of Physical Chemistry B. 2021, Apr 22; 125(15): 3790-3802.
  1. 24.   Proteogenomic and metabolomic characterization of human glioblastoma
  2. Wang, Liang-Bo; Karpova, Alla; Gritsenko, Marina A.; Kyle, Jennifer E.; Cao, Song; Li, Yize; Rykunov, Dmitry; Colaprico, Antonio; Rothstein, Joseph H.; Hong, Runyu; Stathias, Vasileios; Cornwell, MacIntosh; Petralia, Francesca; Wu, Yige; Reva, Boris; Krug, Karsten; Pugliese, Pietro; Kawaler, Emily; Olsen, Lindsey K.; Liang, Wen-Wei; Song, Xiaoyu; Dou, Yongchao; Wendl, Michael C.; Caravan, Wagma; Liu, Wenke; Zhou, Daniel Cui; Ji, Jiayi; Tsai, Chia-Feng; Petyuk, Vladislav A.; Moon, Jamie; Ma, Weiping; Chu, Rosalie K.; Weitz, Karl K.; Moore, Ronald J.; Monroe, Matthew E.; Zhao, Rui; Yang, Xiaolu; Yoo, Seungyeul; Krek, Azra; Demopoulos, Alexis; Zhu, Houxiang; Wyczalkowski, Matthew A.; McMichael, Joshua F.; Henderson, Brittany L.; Lindgren, Caleb M.; Boekweg, Hannah; Lu, Shuangjia; Baral, Jessika; Yao, Lijun; Stratton, Kelly G.; Bramer, Lisa M.; Zink, Erika; Couvillion, Sneha P.; Bloodsworth, Kent J.; Satpathy, Shankha; Sieh, Weiva; Boca, Simina M.; Schurer, Stephan; Chen, Feng; Wiznerowicz, Maciej; Ketchum, Karen A.; Boja, Emily S.; Kinsinger, Christopher R.; Robles, Ana; Hiltke, Tara; Thiagarajan,Mathangi; Nesvizhskii, Alexey; Zhang, Bing; Mani, D. R.; Ceccarelli, Michele; Chen, Xi S.; Cottingham, Sandra L.; Li, Qing Kay; Kim, Albert H.; Fenyo, David; Ruggles, Kelly; Rodriguez, Henry; Mesri, Mehdi; Payne, Samuel H.; Resnick, Adam C.; Wang, Pei; Smith, Richard D.; Iavarone, Antonio; Chheda, Milan G.; Barnholtz-Sloan, Jill S.; Rodland, Karin D.; Liu, Tao; Ding, Li
  3. Cancer Cell. 2021, Apr 12; 39(4): 509-528.e20.
  1. 25.   Frequency of Pathogenic Germline Variants in Cancer-Susceptibility Genes in the Childhood Cancer Survivor Study
  2. Kim, Jung; Gianferante, Matthew; Karyadi, Danielle M.; Hartley, Stephen W.; Frone, Megan N.; Luo,Wen; Robison, Leslie L.; Armstrong, Gregory T.; Bhatia, Smita; Dean,Michael; Yeager,Meredith; Zhu,Bin; Song, Lei; Sampson, Joshua N.; Yasui, Yutaka; Leisenring, Wendy M.; Brodie,Seth; de Andrade, Kelvin C.; Fortes, Fernanda P.; Goldstein, Alisa M.; Khincha, Payal P.; Machiela, Mitchell J.; McMaster, Mary L.; Nickerson, Michael L.; Oba, Leatrisse; Pemov, Alexander; Pinheiro, Maisa; Rotunno, Melissa; Santiago, Karina; Wegman-Ostrosky, Talia; Diver, W. Ryan; Teras, Lauren; Freedman, Neal D.; Hicks,Belynda; Wang,Mingyi; Jones,Kristine; Hutchinson,Amy; Dagnall,Casey; Savage, Sharon A.; Tucker, Margaret A.; Chanock, Stephen J.; Morton, Lindsay M.; Stewart, Douglas R.; Mirabello, Lisa
  3. JNCI cancer spectrum. 2021, Apr; 5(2):
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