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  1. 1.   The effects of RNase H inhibitors and nevirapine on the susceptibility of HIV-1 to AZT and 3TC
  2. Davis, C. A.; Parniak, M. A.; Hughes, S. H.
  3. Virology. 2011, Oct; 419(2): 64-71.
  1. 2.   Mechanisms of HIV-1 drug resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors
  2. Nikolenko, G. N.; Kotelkin, A. T.; Oreshkova, S. F.; Ilyichev, A. A.
  3. Molecular Biology. 2011, Feb; 45(1): 93-109.
  1. 3.   Synthesis and biological evaluation of novel dihydro-aryl/alkylsulfanyl-cyclohexylmethyl-oxopyrimidines (S-DACOs) as high active anti-HIV agents
  2. He, Y. P.; Long, J.; Zhang, S. S.; Li, C.; Lai, C. C.; Zhang, C. S.; Li, D. X.; Zhang, D. H.; Wang, H.; Cai, Q. Q.; Zheng, Y. T.
  3. Bioorganic & Medicinal Chemistry Letters. 2011, Jan; 21(2): 694-697.
  1. 4.   Development of therapeutics for chronic HCV infection
  2. Huang, Z.; Murray, M. G.; Secrist, J. A.
  3. Antiviral Research. 2006, Sep; 71(2-3): 351-362.
  1. 5.   New HIV-1 reverse transcriptase inhibitors based on a tricyclic benzothiophene scaffold: Synthesis, resolution, and inhibitory activity
  2. Krajewski, K.; Zhang, Y. J.; Parrish, D.; Deschamps, J.; Roller, P. P.; Pathak, V. K.
  3. Bioorganic & Medicinal Chemistry Letters. 2006, Jun; 16(11): 3034-3038.
  1. 6.   HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site
  2. Himmel, D. M.; Sarafianos, S. G.; Dharmasena, S.; Hossain, M. M.; McCoy-Simandle, K.; Ilina, T.; Clark, A. D.; Knight, J. L.; Julias, J. G.; Clark, P. K.; Krogh-Jespersen, K.; Levy, R. M.; Hughes, S. H.; Parniak, M. A.; Arnold, E.
  3. Acs Chemical Biology. 2006 1(11): 702-712.
  1. 7.   Crystal structures for HIV-1 reverse transcriptase in complexes with three pyridinone derivatives: A new class of non-nucleoside inhibitors effective against a broad range of drug-resistant strains
  2. Himmel, D. M.; Das, K.; Clark, A. D.; Hughes, S. H.; Benjahad, A.; Oumouch, S.; Guillemont, J.; Coupa, S.; Poncelet, A.; Csoka, I.; Meyer, C.; Andries, K.; Nguyen, C. H.; Grierson, D. S.; Arnold, E.
  3. Journal of Medicinal Chemistry. 2005, DEC 1; 48(24): 7582-7591.
  1. 8.   In search of a novel anti-HIV drug: Multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6dimethylphenyl] amino]-2-pyrimidinyl]amino]-benzonitrile (R278474, rilpivirine)
  2. Janssen, P. A. J.; Lewi, P. J.; Arnold, E.; Daeyaert, F.; de Jonge, M.; Heeres, J.; Koymans, L.; Vinkers, M.; Guillemont, J.; Pasquier, E.; Kukla, M.; Ludovici, D.; Andries, K.; de Bethune, M. P.; Pauwels, R.; Das, K.; Clark, A. D.; Frenkel, Y. V.; Hughes, S. H.; Medaer, B.; De Knaep, F.; Bohets, H.; De Clerck, F.; Lampo, A.; Williams, P.; Stoffels, P.
  3. Journal of Medicinal Chemistry. 2005, MAR 24; 48(6): 1901-1909.
  1. 9.   Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones
  2. Budihas, S. R.; Gorshkova, I.; Gaidamakov, S.; Wamiru, A.; Bona, M. K.; Parniak, M. A.; Crouch, R. J.; McMahon, J. B.; Beutler, J. A.; Le Grice, S. F. J.
  3. Nucleic Acids Research. 2005 33(4): 1249-1256.
  1. 10.   In vitro characterization of a simian immunodeficiency virus-human immunodeficiency virus (HIV) chimera expressing HIV type 1 reverse transcriptase to study antiviral resistance in pigtail macaques
  2. Ambrose, Z.; Boltz, V.; Palmer, S.; Coffin, J. M.; Hughes, S. H.; KewalRamani, V. N.
  3. Journal of Virology. 2004, DEC; 78(24): 13553-13561.
  1. 11.   Taking aim at a moving target: designing drugs to inhibit drug-resistant HIV-1 reverse transcriptases
  2. Sarafianos, S. G.; Das, K.; Hughes, S. H.; Arnold, E.
  3. Current Opinion in Structural Biology. 2004, DEC; 14(6): 716-730.
  1. 12.   Nonnucleoside inhibitor binding affects the interactions of the fingers subdomain of human immunodeficiency virus type 1 reverse transcriptase with DNA
  2. Peletskaya, E. N.; Kogon, A. A.; Tuske, S.; Arnold, E.; Hughes, S. H.
  3. Journal of Virology. 2004 78(7): 3387-3397.
  1. 13.   Human immunodeficiency virus type 2 reverse transcriptase activity in model systems that mimic steps in reverse transcription
  2. Post, K.; Guo, J. H.; Howard, K. J.; Powell, M. D.; Miller, J. T.; Hizi, A.; Le Grice, S. F. J.; Levin, J. G.
  3. Journal of Virology. 2003 77(13): 7623-7634.
  1. 14.   The Lys103Asn mutation of HIV-1 RT: A novel mechanism of drug resistance
  2. Hsiou, Y.; Ding, J. P.; Das, K.; Clark, A. D.; Boyer, P. L.; Lewi, P.; Janssen, P. A. J.; Kleim, J. P.; Rosner, M.; Hughes, S. H.; Arnold, E.
  3. Journal of Molecular Biology. 2001 309(2): 437-445.
  1. 15.   Molecular matchmaking: NNRTIs can enhance the dimerization of HIV type 1 reverse transcriptase
  2. Hughes, S. H.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2001 98(13): 6991-6992.
  1. 16.   Monte Carlo calculations on HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor 8-Cl TIBO: contribution of the L100I and Y181C variants to protein stability and biological activity
  2. Smith, M. B. K.; Lamb, M. L.; Tirado-Rives, J.; Jorgensen, W. L.; Michejda, C. J.; Ruby, S. K.; Smith, R. H.
  3. Protein Engineering. 2000 13(6): 413-421.
  1. 17.   High-level resistance to 3 '-azido-3 '-deoxythimidine due to a deletion in the reverse transcriptase gene of human immunodeficiency virus type 1
  2. Imamichi, T.; Sinha, T.; Imamichi, H.; Zhang, Y. M.; Metcalf, J. A.; Falloon, J.; Lane, H. C.
  3. Journal of Virology. 2000 74(2): 1023-1028.
  1. 18.   Touching the heart of HIV-1 drug resistance: the fingers close down on the dNTP at the polymerase active site
  2. Sarafianos, S. G.; Das, K.; Ding, J. P.; Boyer, P. L.; Hughes, S. H.; Arnold, E.
  3. Chemistry & Biology. 1999 6(5): R137-R146.
  1. 19.   Discovery of novel HIV-1 reverse transcriptase inhibitors using a combination of 3D database searching and 3D QSAR
  2. Zaharevitz, D. W.; Gussio, R.; Wiegand, A.; Jalluri, R.; Pattabiraman, N.; Kellogg, G. E.; Pallansch, L. A.; Yang, S. S.; Buckheit, R. W.
  3. Medicinal Chemistry Research. 1999 9(7-8): 551-564.
  1. 20.   New Alkenyldiarylmethanes With Enhanced Potencies As Anti-Hiv Agents Which Act As Non-Nucleoside Reverse Transcriptase Inhibitors
  2. Cushman, M.; Casimirogarcia, A.; Hejchman, E.; Ruell, J. A.; Huang, M. J.; Schaeffer, C. A.; Williamson, K.; Rice, W. G.; Buckheit, R. W.
  3. Journal of Medicinal Chemistry. 1998 41(12): 2076-2089.
  1. 21.   Structures of Tyr188leu Mutant and Wild-Type Hiv-1 Reverse Transcriptase Complexed With the Non-Nucleoside Inhibitor Hby 097 - Inhibitor Flexibility Is a Useful Design Feature For Reducing Drug Resistance
  2. Hsiou, Y.; Das, K. Y.; Ding, J. P.; Clark, A. D.; Kleim, J. P.; Rosner, M.; Winkler, I.; Riess, G.; Hughes, S. H.; Arnold, E.
  3. Journal of Molecular Biology. 1998 284(2): 313-323.
  1. 22.   Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 angstrom resolution
  2. Ding, J. P.; Das, K.; Hsiou, Y.; Sarafianos, S. G.; Clark, A. D.; Jacobo-Molina, A.; Tantillo, C.; Hughes, S. H.; Arnold, E.
  3. Journal of Molecular Biology. 1998 284(4): 1095-1111.
  1. 23.   Hybrid Ty1/Hiv-1 Elements Used to Detect Inhibitors and Monitor the Activity of Hiv-1 Reverse Transcriptase
  2. Nissley, D. V.; Boyer, P. L.; Garfinkel, D. J.; Hughes, S. H.; Strathern, J. N.
  3. Proceedings of the National Academy of Sciences of the United States of America. 1998 95(23): 13905-13910.
  1. 24.   Prediction of binding affinities for TIBO inhibitors of HIV-1 reverse transcriptase using Monte Carlo simulations in a linear response method
  2. Smith, R. H.; Jorgensen, W. L.; Tirado-Rives, J.; Lamb, M. L.; Janssen, P. A. J.; Michejda, C. J.; Smith, M. B. K.
  3. Journal of Medicinal Chemistry. 1998 41(26): 5272-5286.
  1. 25.   Structure and Mechanism of Action of Nonnucleoside Inhibitors of Hiv-1 Reverse Transcriptase - Strategies to Combat Drug Resistance
  2. Smith, R. H.; Michejda, C. J.; Hughes, S. H.; Arnold, E.; Janssen, P. A. J.; Smith, M. B. K.
  3. Theochem-Journal of Molecular Structure. 1998 423(1-2): 67-77.
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