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  1. 1.   Patterns of metastatic progression and association with clinical outcomes in canine osteosarcoma: A necropsy study of 83 dogs
  2. Silver, K I; Patkar, S; Mazcko, C; Berger,Erika; Beck, J A; LeBlanc, A K
  3. Veterinary and Comparative Oncology. 2023, Aug 17;
  1. 2.   Exploration of Imaging Biomarkers for Metabolically-Targeted Osteosarcoma Therapy in a Murine Xenograft Model
  2. Huang, Shan; Ren, Ling; Beck, Jessica A; Phelps, Tim E; Olkowski, Colleen; Ton, Anita; Roy, Jyoti; White, Margaret E; Adler,Stephen; Wong, Karen; Cherukuri, Aswini; Zhang, Xiang; Basuli, Falguni; Choyke, Peter L; Jagoda, Elaine M; LeBlanc, Amy K
  3. Cancer Biotherapy & Radiopharmaceuticals. 2023, May 29;
  1. 3.   ERK phosphorylation is dependent on cell adhesion in a subset of pediatric sarcoma cell lines
  2. Yoon, Hye-Young; Maron, Ben Y; Girald-Berlingeri, Sofia; Gasilina, Anjelika; Gollin, Josephine C; Jian, Xiaoying; Akpan, Itoro; Yohe,Marielle; Randazzo, Paul A; Chen, Pei-Wen
  3. Biochimica et Biophysica Acta. Molecular Cell Research. 2022, Apr 03; 1869(8):
  1. 4.   Identification of Potential Modulators of Osteosarcoma Metastasis by High Throughput Cellular Screening of Natural Products
  2. Long, Sarah A; Huang, Shan; Kambala, Anusha; Ren, Ling; Wilson,Jennifer; Goetz, Michael; Hao, Xiaojiang; Yang, Xiaosheng; Goncharova,Katya; Jia, Libin; LeBlanc, Amy; Khanna, Chand; Henrich,Curtis; Beutler,John
  3. Chemical biology & drug design. 2020, JUL 28;
  1. 5.   PPAR gamma Agonist Pioglitazone in Combination With Cisplatinum Arrests a Chemotherapy-resistant Osteosarcoma PDOX Model
  2. Higuchi, Takashi; Yamamoto, Jun; Sugisawa, Norihiko; Tashiro, Yoshihiko; Nishino, Hiroto; Yamamoto, Norio; Hayashi, Katsuhiro; Kimura, Hiroaki; Miwa, Shinji; Igarashi, Kentaro; Bouvet, Michael; Singh,Shree Ram; Tsuchiya, Hiroyuki; Hoffman, Robert M
  3. Cancer genomics & proteomics. 2020, Jan-Feb; 17(1): 35-40.
  1. 6.   A Novel Anionic-phosphate-platinum Complex Effectively Targets a Cisplatinum-resistant Osteosarcoma in a Patient-derived Orthotopic Xenograft Mouse Model
  2. Igarashi, Kentaro; Kawaguchi, Kei; Yamamoto, Norio; Hayashi, Katsuhiro; Kimura, Hiroaki; Miwa, Shinji; Higuchi, Takashi; Taniguchi, Yuta; Yonezawa, Hirotaka; Araki, Yoshihiro; Morinaga, Sei; Misra,Sweta; Nelson, Scott D.; Dry, Sarah M.; Li, Yunfeng; Odani, Akira; Singh,Shree Ram; Tsuchiya, Hiroyuki; Hoffman, Robert M.
  3. Cancer genomics & proteomics. 2020, May-Jun; 17(3): 217-223.
  1. 7.   The combination of oral-recombinant methioninase and azacitidine arrests a chemotherapy-resistant osteosarcoma patient-derived orthotopic xenograft mouse model
  2. Higuchi, Takashi; Sugisawa, Norihiko; Yamamoto, Jun; Oshiro, Hiromichi; Han, Qinghong; Yamamoto, Norio; Hayashi, Katsuhiro; Kimura, Hiroaki; Miwa, Shinji; Igarashi, Kentaro; Tan, Yuying; Kuchipudi, Shreya; Bouvet, Michael; Singh,Shree Ram; Tsuchiya, Hiroyuki; Hoffman, Robert M
  3. Cancer chemotherapy and pharmacology. 2019, Nov 08;
  1. 8.   Pioglitazone, an agonist of PPAR?, reverses doxorubicin-resistance in an osteosarcoma patient-derived orthotopic xenograft model by downregulating P-glycoprotein expression
  2. Higuchi, Takashi; Sugisawa, Norihiko; Miyake, Kentaro; Oshiro, Hiromichi; Yamamoto, Norio; Hayashi, Katsuhiro; Kimura, Hiroaki; Miwa, Shinji; Igarashi, Kentaro; Kline,Zoey; Bouvet, Michael; Singh,Shree Ram; Tsuchiya, Hiroyuki; Hoffman, Robert M
  3. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019, Oct; 118: 109356.
  1. 9.   Oral Recombinant Methioninase, Combined With Oral Caffeine and Injected Cisplatinum, Overcome Cisplatinum-Resistance and Regresses Patient-derived Orthotopic Xenograft Model of Osteosarcoma
  2. Higuchi, Takashi; Oshiro, Hiromichi; Miyake, Kentaro; Sugisawa, Norihiko; Han, Qinghong; Tan, Yuying; Park, Junho; Zhang, Zhiying; Razmjooei, Sahar; Yamamoto, Norio; Hayashi, Katsuhiro; Kimura, Hiroaki; Miwa, Shinji; Igarashi, Kentaro; Bouvet, Michael; Chawla, Sant P; Singh,Shree Ram; Tsuchiya, Hiroyuki; Hoffman, Robert M
  3. Anticancer research. 2019, Sep; 39(9): 4653-4657.
  1. 10.   Eribulin Suppressed Cisplatinum- and Doxorubicin-resistant Recurrent Lung Metastatic Osteosarcoma in a Patient-derived Orthotopic Xenograft Mouse Model
  2. Kiyuna, Tasuku; Tome, Yasunori; Miyake, Kentaro; Murakami, Takashi; Oshiro, Hiromichi; Igarashi, Kentaro; Kawaguchi, Kei; Hsu, John; Singh, Manish; Li, Yunfeng; Nelson, Scott; Bouvet, Michael; Singh,Shree Ram; Kanaya, Fuminori; Hoffman, Robert M
  3. Anticancer research. 2019, Sep; 39(9): 4775-4779.
  1. 11.   Combination Treatment With Sorafenib and Everolimus Regresses a Doxorubicin-resistant Osteosarcoma in a PDOX Mouse Model
  2. Higuchi, Takashi; Sugisawa, Norihiko; Miyake, Kentaro; Oshiro, Hiromichi; Yamamoto, Norio; Hayashi, Katsuhiro; Kimura, Hiroaki; Miwa, Shinji; Igarashi, Kentaro; Kline,Zoey; Belt,Paige; Chawla, Sant P; Bouvet, Michael; Singh,Shree Ram; Tsuchiya, Hiroyuki; Hoffman, Robert M
  3. Anticancer research. 2019, Sep; 39(9): 4781-4786.
  1. 12.   Sorafenib and Palbociclib Combination Regresses a Cisplatinum-resistant Osteosarcoma in a PDOX Mouse Model
  2. Higuchi, Takashi; Sugisawa, Norihiko; Miyake, Kentaro; Oshiro, Hiromichi; Yamamoto, Norio; Hayashi, Katsuhiro; Kimura, Hiroaki; Miwa, Shinji; Igarashi, Kentaro; Chawla, Sant P; Bouvet, Michael; Singh,Shree Ram; Tsuchiya, Hiroyuki; Hoffman, Robert M
  3. Anticancer research. 2019, Aug; 39(8): 4079-4084.
  1. 13.   Trabectedin and irinotecan combination regresses a cisplatinum-resistant osteosarcoma in a patient-derived orthotopic xenograft nude-mouse model
  2. Higuchi, Takashi; Miyake, Kentaro; Oshiro, Hiromichi; Sugisawa, Norihiko; Yamamoto, Norio; Hayashi, Katsuhiro; Kimura, Hiroaki; Miwa, Shinji; Igarashi, Kentaro; Chawla, Sant P.; Bouvet, Michael; Singh,Shree Ram; Tsuchiya, Hiroyuki; Hoffman, Robert M.
  3. Biochemical and biophysical research communications. 2019, MAY 28; 513(2): 326-331.
  1. 14.   CAR T Cells Targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors
  2. Majzner, Robbie G.; Theruvath, Johanna L.; Nellan, Anandani; Heitzeneder, Sabine; Cui, Yongzhi; Mount, Christopher W.; Rietberg, Skyler P.; Linde, Miles H.; Xu, Peng; Rota, Christopher; Sotillo, Elena; Labanieh, Louai; Lee, Daniel W.; Orentas, Rimas J.; Dimitrov, Dimiter S.; Zhu, Zhongyu; St Croix,Brad; Delaidelli, Alberto; Sekunova, Alla; Bonvini, Ezio; Mitra, Siddhartha S.; Quezado, Martha M.; Majeti, Ravindra; Monje, Michelle; Sorensen, Poul H. B.; Maris, John M.; Mackall, Crystal L.
  3. CLINICAL CANCER RESEARCH. 2019, APR 15; 25(8): 2560-2574.
  1. 15.   Genome-wide association study identifies the GLDC/IL33 locus associated with survival of osteosarcoma patients
  2. Koster, Roelof; Panagiotou, Orestis A; Wheeler, William A; Karlins, Eric; Gastier-Foster, Julie M; Caminada de Toledo, Silvia Regina; Petrilli, Antonio S; Flanagan, Adrienne M; Tirabosco, Roberto; Andrulis, Irene L; Wunder, Jay S; Gokgoz, Nalan; Patiño-Garcia, Ana; Lecanda, Fernando; Serra, Massimo; Hattinger, Claudia; Picci, Piero; Scotlandi, Katia; Thomas, David M; Ballinger, Mandy L; Gorlick, Richard; Barkauskas, Donald A; Spector, Logan G; Tucker, Margaret; Hicks, Belynda; Yeager, Meredith; Hoover, Robert N; Wacholder, Sholom; Chanock, Stephen J; Savage, Sharon A; Mirabello, Lisa
  3. International journal of cancer. 2018, Apr 15; 142(8): 1594-1601.
  1. 16.   Small molecule inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells
  2. Bulut, G.; Hong, S. H.; Chen, K.; Beauchamp, E. M.; Rahim, S.; Kosturko, G. W.; Glasgow, E.; Dakshanamurthy, S.; Lee, H. S.; Daar, I.; Toretsky, J. A.; Khanna, C.; Uren, A.
  3. Oncogene. 2012, Jan; 31(3): 269-281.
  1. 17.   Hypoxia, stem cells and bone tumor
  2. Zeng, W.; Wan, R.; Zheng, Y. H.; Singh, S. R.; Wei, Y. Y.
  3. Cancer Letters. 2011, Dec; 313(2): 129-136.
  1. 18.   Protein kinase C regulates ezrin-radixin-moesin phosphorylation in canine osteosarcoma cells
  2. Hong, S. H.; Osborne, T.; Ren, L.; Briggs, J.; Mazcko, C.; Burkett, S. S.; Khanna, C.
  3. Veterinary and Comparative Oncology. 2011, Sep; 9(3): 207-218.
  1. 19.   Metastasis-associated gene expression profile of liver and subcutaneous lesions derived from mouse pheochromocytoma cells
  2. Ohta, S.; Lai, E. W.; Morris, J. C.; Pang, A.; Watanabe, M.; Yazawa, H.; Zhang, R.; Green, J. E.; Chan, W. Y.; Sirajuddin, P.; Taniguchi, S.; Powers, J. F.; Tischler, A. S.; Pacak, K.
  3. Molecular Carcinogenesis. 2008 47(4): 245-251.
  1. 20.   The synthetic peptide WKYMVm attenuates the function of the chemokine receptors CCR5 and CXCR4 through activation of formyl peptide receptor-like 1
  2. Li, B. Q.; Wetzel, M. A.; Mikovits, J. A.; Henderson, E. E.; Rogers, T. J.; Gong, W.; Le, Y.; Ruscetti, F. W.; Wang, J. M.
  3. Blood. 2001 97(10): 2941-2947.
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