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  1. 1.   Discovery of potent and selective PROTACs for the protein kinase LZK for the treatment of head and neck cancer
  2. Katerji,Meghri; Bergman, Knickole L; Lindberg, Eric; Rubin,Maxine; Funk, Amy L; Woodroofe, Carolyn C; Nyswaner, Katherine; Karpinska, Kamila; Serwa, Remigiusz; Marusiak, Anna; Swenson, Rolf E; Brognard,John
  3. The Journal of Biological Chemistry. 2025, Mar 27; 108452.
  1. 2.   PKR activation-induced mitochondrial dysfunction in HIV-transgenic mice with nephropathy
  2. Yoshida, Teruhiko; Latt, Khun Zaw; Rosenberg, Avi Z; Santo, Briana A; Myakala, Komuraiah; Ishimoto,Yu; Zhao, Yongmei; Shrivastav, Shashi; Jones, Bryce A; Yang, Xiaoping; Wang, Xiaoxin X; Tutino, Vincent M; Sarder, Pinaki; Levi, Moshe; Okamoto, Koji; Winkler, Cheryl A; Kopp, Jeffrey B
  3. eLife. 2024, Aug 29; 12
  1. 3.   Yuanhuacine Is a Potent and Selective Inhibitor of the Basal-Like 2 Subtype of Triple Negative Breast Cancer with Immunogenic Potential
  2. Fermaintt, Charles S.; Peramuna, Thilini; Cai, Shengxin; Takahashi-Ruiz, Leila; Essif, Jacob Nathaniel; Grant, Corena V.; O'Keefe,Barry; Mooberry, Susan L.; Cichewicz, Robert H.; Risinger, April L.
  3. Cancers. 2021, JUN; 13(11):
  1. 4.   The protein kinase MAP3K19 phosphorylates MAP2Ks and thereby activates ERK and JNK kinases and increases viability of KRAS-mutant lung cancer cells
  2. Hoang, Van T.; Nyswaner,Katherine; Torres-Ayuso,Pedro; Brognard,John
  3. JOURNAL OF BIOLOGICAL CHEMISTRY. 2020, JUN 19; 295(25): 8470-8479.
  1. 5.   PIK3Cd expression by fibroblasts promotes triple-negative breast cancer progression
  2. Gagliano, Teresa; Shah, Kalpit; Gargani, Sofia; Lao, Liyan; Alsaleem, Mansour; Chen, Jianing; Ntafis, Vasileios; Huang, Penghan; Ditsiou, Angeliki; Vella, Viviana; Yadav, Kritika; Bienkowska, Kamila; Bresciani, Giulia; Kang, Kai; Li, Leping; Carter, Philip; Benstead-Hume, Graeme; O'Hanlon,Tim; Dean,Michael; Pearl, Frances Mg; Lee, Soo Chin; Rakha, Emad A; Green, Andrew R; Kontoyiannis, Dimitris L; Song, Erwei; Stebbing, Justin; Giamas, Georgios
  3. The Journal of clinical investigation. 2020, JUN 1; 130(6): 3188-3204.
  1. 6.   Two PKA RIa holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP
  2. Lu, Tsan-Wen; Wu, Jian; Aoto, Phillip C; Weng, Jui-Hung; Ahuja, Lalima G; Sun, Nicholas; Cheng, Cecilia Y; Zhang,Ping; Taylor, Susan S
  3. Proceedings of the National Academy of Sciences of the United States of America. 2019, Aug 13; 116(33): 16347-16356.
  1. 7.   Diacylglycerol Kinase Malfunction in Human Disease and the Search for Specific Inhibitors
  2. Merida, Isabel; Arranz-Nicolás, Javier; Torres-Ayuso,Pedro; Ávila-Flores, Antonia
  3. Handbook of experimental pharmacology. 2019, Jun 22;
  1. 8.   Quantitative biophysical analysis defines key components modulating recruitment of the GTPase KRAS to the plasma membrane
  2. Bindu, Lakshman; Messing, Simon; Schmid, Eva M.; Clogston, Jeffrey; Gillette, Bill; Esposito, Dom; Kessing, Bailey; Fletcher, Daniel A.; Nissley, Dwight; McCormick, Frank; Stephen, Andy; Jean-Francois, Frantz
  3. JOURNAL OF BIOLOGICAL CHEMISTRY. 2019, Feb 8; 294(6): 2193-2207.
  1. 9.   Protein kinase Ca gain-of-function variant in Alzheimer's disease displays enhanced catalysis by a mechanism that evades down-regulation
  2. Callender, Julia A; Yang, Yimin; Lordén, Gema; Stephenson, Natalie L; Jones, Alexander C; Brognard, John; Newton, Alexandra C
  3. Proceedings of the National Academy of Sciences of the United States of America. 2018, Jun 12; 115(24): E5497-E5505.
  1. 10.   NADPH oxidase 1 supports proliferation of colon cancer cells by modulating reactive oxygen species-dependent signal transduction
  2. Juhasz, Agnes; Markel, Susan; Gaur, Shikha; Liu, Han; Lu, Jiamo; Jiang, Guojian; Wu, Xiwei; Antony, Smitha; Wu, Yongzhong; Melillo, Giovanni; Meitzler, Jennifer L; Haines, Diana; Butcher, Donna; Roy, Krishnendu; Doroshow, James H
  3. Journal of Biological Chemistry. 2017, May 12; 292(19): 7866-7887.
  1. 11.   Structural Basis for the Failure of the C1 Domain of Ras Guanine Nucleotide Releasing Protein 2 (RasGRP2) to Bind Phorbol Ester with High Affinity.
  2. Czikora, Agnes; Lundberg, Daniel J; Abramovitz, Adelle; Lewin, Nancy E; Kedei, Noemi; Peach, Megan L; Zhou, Xiaoling; Merritt, Raymond C; Craft, Elizabeth A; Braun, Derek C; Blumberg, Peter M
  3. The Journal of biological chemistry. 2016, May 20; 291(21): 11133-47.
  1. 12.   The importance of Raf dimerization in cell signaling
  2. Freeman, A. K.; Ritt, D. A.; Morrison, D. K.
  3. Small GTPases. 2013, Jul-Sep; 4(3): 180-5.
  1. 13.   Regulation of microtubule-based microtubule nucleation by mammalian polo-like kinase 1
  2. Johmura, Y.; Soung, N. K.; Park, J. E.; Yu, L. R.; Zhou, M.; Bang, J. K.; Kim, B. Y.; Veenstra, T. D.; Erikson, R. L.; Lee, K. S.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2011, Jul; 108(28): 11446-11451.
  1. 14.   Recent Development of Cyclic Amide (Pyridone/Lactam) Moiety Containing Heterocycles as Protein Kinase Inhibitors
  2. Wei, L. Y.; Malhotra, S. V.
  3. Current Medicinal Chemistry. 2010, Jan; 17(3): 234-253.
  1. 15.   Overproduction, purification and structure determination of human dual-specificity phosphatase 14
  2. Lountos, G. T.; Tropea, J. E.; Cherry, S.; Waugh, D. S.
  3. Acta crystallographica. Section D, Biological crystallography. 2009, Oct; 65(Pt 10): 1013-20.
  1. 16.   Signaling dynamics of the KSR1 scaffold complex
  2. McKay, M. M.; Ritt, D. A.; Morrison, D. K.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2009, Jul 7; 106(27): 11022-7.
  1. 17.   Influence of the dual ABCB1 and ABCG2 inhibitor tariquidar on the disposition of oral imatinib in mice
  2. Gardner, E. R.; Smith, N. F.; Figg, W. D.; Sparreboom, A.
  3. Journal of experimental & clinical cancer research : CR. 2009 28: 99.
  1. 18.   Interleukin 10 and TNF alpha synergistically enhance the expression of the G protein-coupled formylpeptide receptor 2 in microglia
  2. Iribarren, P.; Chen, K.; Gong, W.; Cho, E. H.; Lockett, S.; Uranchimeg, B.; Wang, J. M.
  3. Neurobiology of Disease. 2007, Jul; 27(1): 90-98.
  1. 19.   Serine-phosphorylated STAT1 is a prosurvival factor in Wilms' tumor pathogenesis
  2. Timofeeva, O. A.; Plisov, S.; Evseev, A. A.; Peng, S.; Jose-Kampfner, M.; Lovvorn, H. N.; Dome, J. S.; Perantoni, A. O.
  3. Oncogene. 2006, Dec; 25(58): 7555-7564.
  1. 20.   Accelerated tumor formation in a fatless mouse with type 2 diabetes and inflammation
  2. Nunez, N. P.; Oh, W. J.; Rozenberg, J.; Perella, C.; Anver, M.; Barrett, J. C.; Perkins, S. N.; Berrigan, D.; Moitra, J.; Varticovski, L.; Hursting, S. D.; Vinson, C.
  3. Cancer Research. 2006, MAY 15; 66(10): 5469-5476.
  1. 21.   Conditional up-regulation of IL-2 production by p38 MAPK inactivation is mediated by increased Erk1/2 activity
  2. Kogkopoulou, O.; Tzakos, E.; Mavrothalassitis, G.; Baldari, C. T.; Paliogianni, F.; Young, H. A.; Thyphronitis, G.
  3. Journal of Leukocyte Biology. 2006, May; 79(5): 1052-1060.
  1. 22.   Enhanced soluble protein expression using two new fusion tags
  2. Chatterjee, D. K.; Esposito, D.
  3. Protein Expression and Purification. 2006, MAR; 46(1): 122-129.
  1. 23.   Novel human monoclonal antibodies to insulin-like growth factor (IGH)-II that potently inhibit the IGF receptor type I signal transduction function
  2. Feng, Y.; Zhu, Z. Y.; Xiao, X. D.; Choudhry, V.; Barrett, J. C.; Dimitrov, D. S.
  3. Molecular Cancer Therapeutics. 2006, JAN; 5(1): 114-120.
  1. 24.   The RIO kinases: An atypical protein kinase family required for ribosome biogenesis and cell cycle progression
  2. Laronde-Leblanc, N.; Wlodawer, A.
  3. Biochimica Et Biophysica Acta-Proteins and Proteomics. 2005, DEC 30; 1754(1-2, Sp. Iss.): 14-24.
  1. 25.   Actin is the primary cellular receptor of bistramide A
  2. Statsuk, A. V.; Bai, R. L.; Baryza, J. L.; Verma, V. A.; Hamel, E.; Wender, P. A.; Kozmin, S. A.
  3. Nature Chemical Biology. 2005, DEC; 1(7): 383-388.
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