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  1. 1.   RS6077 induces mitotic arrest and selectively activates cell death in human cancer cell lines and in a lymphoma tumor in vivo
  2. Sebastiani, Jessica; Puxeddu, Michela; Nalli, Marianna; Bai,Ruoli; Altieri, Ludovica; Rovella, Paola; Gaudio, Eugenio; Trisciuoglio, Daniela; Spriano, Filippo; Lavia, Patrizia; Fionda, Cinzia; Masci, Domiziana; Urbani, Andrea; Bigogno, Chiara; Dondio, Giulio; Hamel,Ernest; Bertoni, Francesco; Silvestri, Romano; La Regina, Giuseppe
  3. European Journal of Medicinal Chemistry. 2022, Dec 05; 246: 114997.
  1. 2.   Targeting chemoresistance in Xp11.2 translocation renal cell carcinoma using a novel polyamide-chlorambucil conjugate
  2. Funasaki, Shintaro; Mehanna, Sally; Ma, Wenjuan; Nishizawa, Hidekazu; Kamikubo, Yasuhiko; Sugiyama, Hiroshi; Ikeda, Shuji; Motoshima, Takanobu; Hasumi, Hisashi; Linehan, W Marston; Schmidt,Laura; Ricketts, Chris; Suda, Toshio; Oike, Yuichi; Kamba, Tomomi; Baba, Masaya
  3. Cancer Science. 2022, Apr 09;
  1. 3.   Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia
  2. Puxeddu, Michela; Shen, Hongliang; Bai,Ruoli; Coluccia, Antonio; Bufano, Marianna; Nalli, Marianna; Sebastiani, Jessica; Brancaccio, Diego; Da Pozzo, Eleonora; Tremolanti, Chiara; Martini, Claudia; Orlando, Viviana; Biagioni, Stefano; Sinicropi, Maria Stefania; Ceramella, Jessica; Iacopetta, Domenico; Coluccia, Addolorata Maria Luce; Hamel,Ernest; Liu, Te; Silvestri, Romano; La Regina, Giuseppe
  3. European journal of medicinal chemistry. 2021, Oct 5; 221
  1. 4.   Agelasine Diterpenoids and Cbl-b Inhibitory Ageliferins from the Coralline Demosponge Astrosclera willeyana
  2. Jiang, Wei; Wang,Dongdong; Wilson,Brice; Kang, Unwoo; Bokesch, Heidi R; Smith,Emily; Wamiru,Antony; Goncharova,Katya; Voeller, Donna; Lipkowitz, Stanley; O'Keefe,Barry; Gustafson,Kirk
  3. Marine drugs. 2021, Jun 24; 19(7):
  1. 5.   A facile synthesis of diaryl pyrroles led to the discovery of potent colchicine site antimitotic agents
  2. Romagnoli, Romeo; Oliva, Paola; Salvador, Maria Kimatrai; Manfredini, Stefano; Padroni, Chiara; Brancale, Andrea; Ferla, Salvatore; Hamel,Ernest; Ronca, Roberto; Maccarinelli, Federica; Rruga, Fatlum; Mariotto, Elena; Viola, Giampietro; Bortolozzi, Roberta
  3. European Journal of Medicinal Chemistry. 2021, Mar 15; 214
  1. 6.   Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies
  2. Puxeddu, Michela; Shen, Hongliang; Bai,Ruoli; Coluccia, Antonio; Nalli, Marianna; Mazzoccoli, Carmela; Da Pozzo, Eleonora; Cavallini, Chiara; Martini, Claudia; Orlando, Viviana; Biagioni, Stefano; Mazzoni, Cristina; Coluccia, Addolorata Maria Luce; Hamel,Ernest; Liu, Te; Silvestri, Romano; La Regina, Giuseppe
  3. European journal of medicinal chemistry. 2020, Jan 1; 185: 111828.
  1. 7.   3-Aroyl-1,4-diarylpyrroles Inhibit Chronic Myeloid Leukemia Cell Growth through an Interaction with Tubulin
  2. La Regina, Giuseppe; Bai, Ruoli; Coluccia, Antonio; Famiglini, Valeria; Passacantilli, Sara; Naccarato, Valentina; Ortar, Giorgio; Mazzoccoli, Carmela; Ruggieri, Vitalba; Agriesti, Francesca; Piccoli, Claudia; Tataranni, Tiziana; Nalli, Marianna; Brancale, Andrea; Vultaggio, Stefania; Mercurio, Ciro; Varasi, Mario; Saponaro, Concetta; Sergio, Sara; Maffia, Michele; Coluccia, Addolorata Maria Luce; Hamel, Ernest; Silvestri, Romano
  3. ACS Medicinal Chemistry Letters. 2017, Apr 26; 8(5): 521-526.
  1. 8.   4,5-Diaryl-1H-pyrrole-2-carboxylates as combretastatin A-4/lamellarin T hybrids: Synthesis and evaluation as anti-mitotic and cytotoxic agents
  2. Banwell, M. G.; Hamel, E.; Hockless, D. C. R.; Verdier-Pinard, P.; Willis, A. C.; Wong, D. J.
  3. Bioorganic & Medicinal Chemistry. 2006, Jul; 14(13): 4627-4638.
  1. 9.   Total synthesis of (+/-)-rhazinal, an alkaloidal spindle toxin from Kopsia teoi
  2. Banwell, M. G.; Edwards, A. J.; Jolliffe, K. A.; Smith, J. A.; Hamel, E.; Verdier-Pinard, P.
  3. Organic & Biomolecular Chemistry. 2003 1(2): 296-305.
  1. 10.   Regulation of nitric oxide synthase II expression by pyrroline-5-carboxylate under hypoxic conditions
  2. Donald, S. P.; Mei, J. M.; Downing, S. J.; Phang, J. M.
  3. Annual Meeting of the American Association for Cancer Research. 1997, 38 A3733.
  1. 11.   Design, Synthesis and in vitro Anti-Cancer evaluation of Novel Derivatives of 2-(2-Methyl-1,5-diaryl-1H-pyrrol-3-yl)-2-oxo-N-(pyridin-3-yl)acetamide
  2. Moghadam, Ebrahim Saeedian; Saravani, Farhad; Hamel,Ernest; Shahsavari, Zahra; Alipour, Mohsen; Hosseinkhani, Saman; Ostad, Seyednasser; Amini, Mohsen
  3. Medicinal chemistry (Shariqah (United Arab Emirates)). 2020 16(3): 340-349.
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