ACUC Bethesda Regulations, Policies, and Guidelines

Technical

Guideline/Policy Revised/Approved
Blood Collection Guidelines for Macaques 4/27/11
Expectations for Personnel Performing Surgery 4/27/11
Guidelines for Endpoint Criteria and Determination of Moribund Condition 4/24/09
IV Injection Recommendations for Mice 10/20/10
Ketamine combinations for rodent anesthesia 10/20/10
Maximum Injection Volumes and Needle Size Recommendations 4/27/11
Mechanisms for Responding to Allegations of Animal Welfare Concerns or Improper Treatment of Animals 4/27/11
Methods of Euthanasia 5/31/2011
Mouse Breeding and Weaning 10/20/10
Procedures Involving Pain or Distress 4/27/11
Postoperative Analgesic and Care Recommendations for Mice 4/27/11
Use of Tribromoethanol (Avertin) in Rodents 10/20/10

IACUC

Guideline/Policy Revised/Approved
Animal Study Proposal Guidance for Animal Numbers Justification 4/27/11
Chemical Hazard Use 4/27/11
Notification Plan for Animal Study Proposal Renewals and Annual Reviews 10/20/10
Required Testing of Cell Lines Prior to Introduction into Rodents 4/27/11
Transportation of Animals between the NCI-Frederick and NIH-Bethesda 10/20/10
Tumor Cell Lines and Biological Materials Screening 04/26/06

NIH ARAC Guidelines

Guideline Regarding Significant Changes to ASPs
IC Collaborations Involving Animal Activities Performed Inside NIH Laboratories or Special Purpose Areas
NIH Animal Transportation Guidelines
1a. Guidelines for NIH Rodent Transportation
1b. Guidelines for NIH Non-Rodent Transportation
NIH Animal Transfer Agreement
Housing Multiple Species of Large Laboratory Animals
Guidelines for Diet Control in Behavioral Studies
Guidelines for the Research Use of Adjuvants
Guidelines for Survival Rodent Surgery
Oocyte Harvesting in Xenopus Laevis
Guidelines for the Prevention and Control of Tuberculosis in Nonhuman Primates
Recommendations on Toe Clipping Animals
Ascites Production in Mice
Pain and Distress in Rodents and Rabbits: Responsibilities, Recognition, and Alleviation
Endpoints in Animal Study Proposals
Guidelines for the Euthanasia of Mouse and Rat Fetuses and Neonates
Minimum Requirements for Protective Clothing in Animal Facilities
Guidelines for Survival Bleeding of Mice and Rats
Guidelines for Euthanasia of Rodents Using Carbon Dioxide
Guidelines for the Genotyping of Rodents
Guideline for Review and Approval of Animal Study Proposals
ACUC Oversight of Animal Activities in Mandated and Non-mandated Areas
1a. Shared/central facilities
1b. Satellites/labs

NIH Policy Manuals

Manual 3040-2 Animal Care and Use in the Intramural Program
Manual 3040-3 Intramural Contracts Involving Animals
Manual 3043-1 Introduction of Rodents and Rodent Products
Manual 3044-1 Nonhuman Primate Quarantine
Manual 3044-2 Protection of NIH Personnel Who Work with Nonhuman Primates
Manual 3047 Trans-NIH Animal Facility Security Program
Manual 1345 Handling and Safeguarding of Controlled Substance for Nonhuman Use
Manual 1130 Delegations of Authority

Federal Regulations and Standards

Animal Welfare Act Congress established this Act to ensure that all animals (excluding mice, rats, and birds) are provided humane care and treatment.

Guide for the Care and Use of Laboratory Animals The Guide is used "to assist institutions in caring for and using animals in ways judged to be scientifically, technically, and humanely appropriate. It also serves to assist investigators in fulfilling their obligation to plan and conduct animal experiments in accord with the highest scientific, humane, and ethical principles."

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research Expanding on the Guide for the Care and Use of Laboratory Animals, this publication provides current best practices for animal care and use and discusses how applicable regulations and guidelines can be applied to neuroscience and behavioral research. It encourages the use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards that ensure animal well-being and high-quality research.

PHS Policy on the Humane Care and Use of Laboratory Animals This policy is intended to ensure that PHS grantees and contractors care for and use animals humanely.

U.S. Government Principles for the Utilization and Care of Vertebrate Animals Used in Testing, Research, and Training These principles were developed specifically for U.S. Government agencies to follow when conducting testing, research, or training procedures involving vertebrate animals.

AVMA Guidelines for the Euthanasia of Animals: 2013 Edition This document provides guidance on euthanasia methods and agents to ensure that animals are relieved from unnecessary pain and suffering.

USDA Animal Care Policy Manual This is a resource guide that provides additional clarification on the intent of the Animal Welfare Act.