Mouse models of human cancer have had a profound impact on our current understanding of mechanisms of tumorigenesis and the pathways regulated by cancer-related genes. These models hold the promise of serving as critical tools in the discovery and testing of novel therapeutics to be used in the treatment and prevention of cancer.
The Transgenic Mouse Model Laboratory (TMML) provides assistance to the scientific community with the generation of genetically engineered mice (GEM), offering a complete array of technologies aimed at the successful generation of transgenic and gene-targeted mice, their expansion and cryopreservation.
Generation of transgenic mice by pronuclear microinjection:
Generation of Knock out and knock in by gene targeting:
For additional reference, please see a list of Publications relevant to research in the Transgenic Mouse Model Laboratory.