All seminars will be held in Building 549 Main Auditorium from 12:00 - 1:00pm unless otherwise noted.

All Students must complete the Ethics and Scientific Research On-Line Training at http://ncifrederick.cancer.gov/Programs/Training/EthicsCourse.aspx

2013 Speakers

Date Speaker Title Details
June 18 Dr. Paul Tooley A Trio of Globally Destructive Plant Pathogens in the Genus Phytophthora
June 25 Dr. David Wink (NCI) Inflammatory Mechanism of Nitric oxide synthase 2 in promotion of poor outcome in ER negative breast cancer
July 2 Dr. Stephen Cendrowski (NBACC) Career Paths in Microbiology
July 9 Dr. Shyam Sharan (NCI) Too many mutations, too little time: making sense of missense mutations in breast cancer susceptibility genes
  • Kuznetsov, S.G., Liu, P. and Sharan, S.K. (2008) Mouse ES-cell-based functional assay to evaluate mutations in BRCA2. Nature Medicine 8:875-881 http://www.nature.com/nm/journal/v14/n8/pdf/nm.1719.pdf
  • Chang, S., Biswas, K., Martin, B.K., Stauffer, S. and Sharan, S.K.. (2009) Expression of human BRCA1 variants in mouse ES cells allows functional analysis of BRCA1 mutationsJournal of Clinical Investigation 119:3160-3171. http://www.jci.org/articles/view/39836
  • Biswas, K., Das, R., Alter, B.P., Kuznetsov, S.G., Stauffer, S., North, S.L., Brody, L. C., Meyer, S., Byrd R.A. and Sharan, S.K. (2011) A comprehensive functional characterization of BRCA2 variants associated with Fanconi anemia using mouse ES cell-based assay. Blood 118:2430-42. http://bloodjournal.hematologylibrary.org/content/118/9/2430.full.pdf+html
  • Chang, S., Wang, R., Agaki, K., Kim, K., Martin, B.K., Cavallone, L., Haines, D., Basik, M., Mai, P., Poggi, E., Issacs, C., Looi, L., Mun, K., Greene, M., Byers, S., Teo, S., Deng, C.-X., and Sharan, S.K. (2011) Tumor Suppressor BRCA1 epigenetically controls oncogenic miRNA-155. Nature Medicine 17:1275-1283. http://www.nature.com/nm/journal/v17/n10/pdf/nm.2459.pdf
  • Biswas K, Das R, Eggington JM, Qiao H, North SL, Stauffer S, Burkett SS, Martin BK, Southon E, Sizemore SC, Pruss D, Bowles KR, Roa BB, Hunter N, Tessarollo L, Wenstrup RJ, Byrd RA, and Sharan SK. (2012) Functional evaluation of BRCA2 variants mapping to the PALB2-binding and C-terminal DNA-binding domains using a mouse ES cell-based assay. Hum Mol Genet. 2012 21:3993-4006.http://hmg.oxfordjournals.org/content/21/18/3993.full
July 16 Dr. Jay Schneekloth Wrestling with SUMO: Chemical Approaches to a Biological Problem
July 23 Dr. Kei Amemiya From the rat flea to bean sprouts: biofilms by old and new emerging pathogens
  • Amemiya K, Meyers JL, Rogers TE, Fast RL, Bassett AD, Worsham PL, Powell BS, Norris SL, Krieg AM, Adamovicz J. 2009. CpG oligodeoxynucleotides augment the murine immune response to the Yersinia pestis F1-V vaccine in bubonic and pneumonic models of plague. Vaccine 27:2220-2229. http://www.sciencedirect.com/science/article/pii/S0264410X09002345
  • Xiao X, Zhu Z, Dankmeyer JL, Wormald MM, Fast RL, Worsham PL, Cote CK, Amemiya K, Dimitrov DS. 2010. Human anti-plague monoclonal antibodies protect mice from Yersinia pestis in a bubonic plague model. PLOS One 5, e13047http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954148
July 30 Dr. Barry O'Keefe What They Missed in Herbology 101: Proteins from Natural Product Extracts
  • Newman DJ, Cragg GM. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J Nat Prod. 2012 Mar 23;75(3):311-35. http://pubs.acs.org/doi/pdf/10.1021/np200906s
  • O'Keefe, B.R., Biologically active proteins from natural product extracts. J. Nat. Prod. 64, 1373-1381, 2001. http://pubs.acs.org/doi/pdf/10.1021/np0103362
  • Mori, T., O'Keefe, B.R.*, Sowder, R.C. 2nd, Bringans, S., Gardella, R., Berg, S., Cochran, P., Turpin, J.A., Buckheit, R.W. Jr, McMahon, J.B., & Boyd, M,R. Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp. J. Biol. Chem. 280: 9345-9353, 2005. http://www.jbc.org/content/280/10/9345.long
  • O'Keefe, B.R., Vojdani, F., Buffa, V., Shattock, R.J., Montefiori, D.C., Bakke, J., Mirsalis, J., d'Andrea, A.L., Hume, S.D., Bratcher, B., Saucedo, C.J., McMahon, J.B., Pogue, G.P., Palmer, K.E. Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component. Proc. Natl. Acad. Sci. (USA) 106: 6099-104, 2009. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662964
  • Service RF. American Chemical Society fall meeting, 16-20 August, Washington, D.C. Sugary Achilles' heel raises hope for broad-acting antiviral drugs. Science. 2009 Sep 4;325(5945):1200. http://www.sciencemag.org/content/325/5945/1200.1.long
August 6 Dr. Lauren Keith (NIAID) Medical Imaging as a Tool in Infectious Disease Research

This seminar series is sponsored by the National Interagency Confederation for Biological Research (NICBR). The NICBR includes the following agencies National Cancer Institute at Frederick (NCI-F), United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Centers for Disease Control (CDC), US Department of Agriculture Foreign Disease Weed Science Research Unit (USDA FDWSRU), US Department of Homeland Security National Biodefense Analysis and Countermeasures Center (DHS NBACC), National Institute of Allergy and Infectious Diseases Integrated Research Facility (NIAID IRF), and the Navy Medical Biodefense Research Lab (NMBDRL). The series is open to all NICBR students and employees. Students from outside the Frederick National Lab and Ft. Detrick communities are also welcome.