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Target Biology Lab

Dr. Matthew Holderfield


Matthew Holderfield

Senior Scientist

Project Team Leader: RAS Target Biology



University of California, Irvine Department of Molecular Biology and  Biochemistry – PhD, mentor: Christopher Hughes

Novartis Institutes for Biomedical Research – Post–doc, mentors: Darrin Stuart, Tobi Nagel

University of California, San Francisco Helen Diller Family Comprehensive Cancer Center – Post–doc, mentor: Frank McCormick



Matthew Holderfield earned his PhD at UC Irvine studying NOTCH signaling in microvasculature with Christopher Hughes. He completed his postdoctoral training at the Novartis Institutes for Biomedical Research and with Frank McCormick at the UCSF Comprehensive Cancer Center where he studied RAF kinase inhibitors and mechanisms of BRAF oncogene activation. Matt recently joined the Frederick National Laboratory for Cancer Research as a Senior Scientist where his research efforts are focused on developing novel therapeutic approaches to treat KRAS mutated cancers. Current areas of interest include:

1) Characterizing the KRAS signaling complex and understanding regulation of complex formation

2) KRAS-effector protein-protein interactions

3) KRAS oncogenic allele specific signal transduction

4) MAP kinase pathway dependence in cancer

Page last updated June 25, 2014 @ 5:58 pm