Imaging and Nanotechnology
The Imaging and Nanotechnology Group is headed by Scott McNeil and consists of three laboratories: Electron Microscopy Laboratory, Optical Microscopy And Analysis Laboratory, and Nanotechnology Characterization Laboratory.
Electron Microscopy Laboratory provides expertise in:
- Transmission Electron Microscopy including ultrastructure analysis, virus particle identification, and negative staining.
- Scanning Electron Microscopy including EDS microanalysis, low voltage imaging, and microenviroment control for customized imaging.
- Cryo Electron Microscopy for aiding in the analysis of 3D morphology.
- Consultation in designing custom protocols, sample processing and embedding, and operational training is available.
Optical Microscopy And Analysis Laboratory provides the following services:
- Light Microscopy including fluorescent, inverted, and stereo LM.
- Confocal Microscopy including bright-field, phase, FRAP, FRET, and time-lapse imaging of live cells.
- Image Analysis including deconvolution, quantification of structural and molecular properties, and measurement of the spatial organization of cells within tissue.
- Training is available for the confocal microscopes.
Nanotechnology Characterization Laboratory provides expertise in:
- Physical and chemical characterization of nanomaterials including size, size distribution, surface charge, zeta potential, purity, stability, and elemental analysis.
- In vitro characterization of nanomaterials including blood contact properties, sterility, general toxicity, molecular mechanisms causing toxicity, and immunotoxicity.
- In vivo characterization of nanomaterials for identifying parameters related to absorption, distribution, metabolism, excretion, and toxicity profiles.