Trehalose distribution in brain tissue by MALDI imaging
This study is in collaboration with the Nanotechnology Characterization Laboratory. Trehalose treatment of animal models of neurodegenerative disease prevents the abnormal accumulation of protein aggregates in neurons. As protein aggregate accumulation is a hallmark of many neurodegenerative diseases, including Alzheimer’s, Parkinson’s and Huntington’s disease, and appears to play a role in disease etiology, these findings have important implications with regard to therapy. To treat CNS disease, brain distribution of trehalose needs to be evaluated. MALDI imaging is an ideal analytical tool that can examine regional brain uptake of trehalose. We selected the appropriated MS/MS transition and the energy absorbing matrix that guarantees the efficient ionization of the sugar.
Preliminary results will be presented at the 60th Conference on Mass Spectrometry and Allied Topics in Vancouver, Canada (May 19th-20th).