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What’s New at PEL


Recent Publications

The PEL collaborates closely with NCI investigators as well as engages in technology development.  The publications below highlight these activities.

Protein Expression in Mammalian CellsProtein Expression in Mammalian Cells. Methods and Protocols. Humana Press, 2011, James Hartley, editor.







Hudson RS, Yi M, Esposito D, Watkins SK, Hurwitz AA, Yfantis HG, Lee DH, Borin JF, Naslund MJ, Alexander RB, Dorsey TH, Stephens RM, Croce CM, and Ambs S: MicroRNA-1 is a candidate tumor suppressor and prognostic marker in human prostate cancer. Nucl. Acids. Res. 40(8): 3689-3703, 2012.

Vyas VV, Esposito D, Sumpter TL, Broadt TL, Hartley J, Knapp GC, Cheng W, Jiang MS, Roach JM, Yang X, Giardina SL, Mitra G, Yovandich JL, Creekmore SP, Waldmann TA, Zhu J: Clinical manufacturing of recombinant human interleukin 15. I. Production cell line development and protein expression in E. coli with stop codon optimization. Biotechnol. Prog. 28(2): 497-507, 2012.

Nellis DF, Michiel DF, Jiang MS, Esposito, D., Davis R, Jiang H, Korrell A, Knapp GC, Lucernoni LE, Nelson RE, Pritt EM, Procter LV, Rogers M, Sumpter TL, Vyas VV, Waybright TJ, Yang X, Zheng AM, Yovandich JL, Gilly JA, Mitra G, and Zhu J: Characterization of recombination human IL-15 deamidation and its practical elimination through substitution of asparagine 77. Pharm Res. 29(3): 722-38, 2012.

Buckle AM, Bate MA, Androulakis S, Cinquanta M, Basquin J, Bonneau F, Chatterjee DK, Cittaro D, Gräslund S, Gruszka A, Page R, Suppmann S, Wheeler JX, Agostini D, Taussig M, Taylor CF, Bottomley SP, Villaverde A, de Marco A: Recombinant protein quality evaluation: proposal for a minimal information standard.  Stand Genomic Sci. 2011.

Kearney MF, Lee K, Bagni RK, Wiegand A, Spindler J, Maldarelli F, Pinto PA, Linehan WM, Vocke CD, Delviks-Frankenberry KA, Devere White RW, Del Prete GQ, Mellors JW, Lifson JD, Kewalramani VN, Pathak VK, Coffin JM, Le Grice SF: Nucleic Acid, Antibody, and Virus Culture Methods to Detect Xenotropic MLV-Related Virus in Human Blood Samples. Adv Virol. 2011.

Delviks-Frankenberry KA, Chaipan C, Bagni R, Wyvill K, Yarchoan R, Pathak VK: Lack of Detection of Xenotropic Murine Leukemia Virus-Related Virus in HIV-1 Lymphoma Patients. Adv Virol. 2011.

Kaczmarczyk SJ, Sitaraman K, Young HA, Hughes SH, Chatterjee DK: Protein delivery using engineered virus-like particles. Proc Natl Acad Sci U S A. Oct 11;108(41) 2011.

Sitaraman K, Chatterjee DK: Protein-protein interactions: an application of Tus-Ter mediated protein microarray system. Methods Mol Biol. 723:185-200 2011.

Kurotani R, Okumura S, Matsubara T, Yokoyama U, Buckley JR, Tomita T, Kezuka K, Nagano T, Esposito D, Taylor TE, Gillette WK, Ishikawa Y, Abe H, Ward JM, Kimura S: Secretoglobin 3A2 Suppresses Bleomycin-induced Pulmonary Fibrosis by Transforming Growth Factor {beta} Signaling Down-regulation. J Biol Chem. 3;286(22). 2011.

Hayashi R, Tanoue K, Durell SR, Chatterjee DK, Miller Jenkins LM, Appella DH, Appella E: Optimization of a Cyclic Peptide Inhibitor of Ser/Thr Phosphatase PPM1D (Wip1). Biochemistry, 2011.

Ganatra MB, Vainauskas S, Hong JM, Taylor TE, Denson JP, Esposito D, Read JD, Schmeisser H, Zoon KC, Hartley JL, Taron CH: A set of aspartyl protease-deficient strains for improved expression of heterologous proteins in Kluyveromyces lactis. FEMS Yeast Res. 2011.

Gillette WK, Esposito D, Taylor TE, Hopkins RF, Bagni RK, Hartley JL: Purify First: Rapid Expression and Purification of Proteins from XMRV. Protein Expr Purif. 2011.

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