Agenda

Click here to download the most recent version of the Conference Program book, which includes a complete agenda and the full text of submitted abstracts.

Monday, May 13, 2024

08:30 am - 09:15 am EST
Session 1: Welcome and Opening Keynote Lecture

Session chairs: Sean Agbor-Enoh, M.D., Ph.D., Esta Sterneck, Ph.D., and Adam Sowalsky, Ph.D.

 

Welcoming remarks

James Gulley, M.D., Ph.D.

Clinical Director, National Cancer Institute, NIH

Richard Childs, M.D.

Scientific Director, National Heart, Lung and Blood Institute, NIH

          

Opening keynote lecture: Improving cancer liquid biopsies through framentomics and population studies

Dennis Lo, Ph.D.

2022 Awardee of the Lasker-DeBakey Clinical Medical Research Award
Professor of Chemical Biology, The Chinese University of Hong Kong

Introduction by Sean Agbor-Enoh, M.D., Ph.D.

09:15 am - 10:30 am EST
Session 2: Education Session – Foundations in Liquid Biopsies

Session chairs: Bruna Pellini, M.D. and Sarven Sabunciyan, Ph.D.

 

Foundations in placental liquid biopsies

Angie Jelin, M.D., Associate Professor of Gynecology and Obstetrics, Johns Hopkins

 

Principles and applications of RNA liquid biopsy               

Iwijn De Vlaminck, Ph.D., Associate Professor of Biomedical Engineering, Cornell University

               

Plasma-derived extracellular vesicle and particle proteins as biomarkers for cancer diagnostics and prognostics

David Lyden, M.D., Ph.D., Professor of Pediatrics, Weill Cornell Medical College

 

Tapping into the genome: Foundations of CSF circulating tumor DNA liquid biopsy in CNS tumors

Alexandra Miller, M.D., Ph.D., Associate Professor of Neurology, NYU Langone

               

Foundations in ctDNA testing after curative-intent treatment in NSCLC

Bruna Pellini, M.D., Assistant Member of Thoracic Oncology, Moffitt Cancer Center

 

10:30 am - 11:00 am EST

Coffee/tea break with light refreshments

Supported by Foundation Medicine, Inc.

11:00 am - 01:00 pm EST
Session 3: Liquid Biopsies of Cells and Extracellular Vesicles in Circulation

Session chairs: Ignatia Barbara Van den Veyver, M.D., and Esta Sterneck, Ph.D.

 

Extracellular vesicles and CTCs in lung cancer, clinical application

Christian Rolfo, M.D., Professor of Hematology and Oncology, Icahn School of Medicine at Mount Sinai

 

Intact fetal cell-based and cell-free DNA-based approaches for non-invasive prenatal screening and testing

Ignatia Barbara Van den Veyver, M.D., Professor of Obstetrics and Gynecology and Molecular and Human Genetics, Baylor College of Medicine

               

The utility of Liquid Biopsy in Immuno-Oncology: an emphasis on circulating tumor cells

Catherine Alix-Panabières, Ph.D., Professor of Medicine, University Medical Centre of Montpellier

 

An indocyanine green-based liquid biopsy test for circulating tumor cells for pediatric liver cancer
Sarah Woodfield, Ph.D., Assistant Professor of Surgery, Baylor College of Medicine

 

Circulating tumor extracellular vesicles to monitor metastatic prostate cancer genomics and transcriptomic evolution

Irene Casanova Salas, Ph.D., La Caixa Junior Leader Fellow, Vall d'Hebron Institute of Oncology

01:00 pm - 03:00 pm EST
Lunch and Poster Session

Poster session

1:00–3:00 pm

 

Boxed lunch

Supported by Foundation Medicine. Inc.

 

Lunch career roundtable discussions (advance sign-up required)

1:15–2:00pm

Angie Jelin, M.D.: Physician scientist in prenatal genetics

Bruna Pellini, M.D.: Thoracic medical oncologist and clinical/translational investigator at a large academic cancer center (clinical trials development and ctDNA applications in lung cancer)

Alexander Wyatt, Ph.D.: Genomic scientist in clinical trial correlative research

 

03:00 pm - 05:00 pm EST
Session 4: Development of Liquid Biopsy Technologies

Session chairs: Alexandra Miller, M.D., Ph.D. and Aaron Newman, Ph.D.

 

TEMPO: Integrating liquid biopsy proteomics with gene expression data 

Vinit B. Mahajan M.D., Ph.D., Professor of Ophthalmology, Stanford University

 

Leveraging AI in Nanotechnology for Precision Liquid Biopsies and Diagnosis

Tony Y. Hu, Ph.D., F-NAI, F-AIMBE, Distinguished Professor of Biochemistry and Molecular Biology, Biomedical Engineering, and Microbiology, Tulane University

 

Solid and liquid determinants of cancer immunotherapy response

Aaron Newman, Ph.D., Assistant Professor of Biomedical Data Science, Stanford University

 

Genome-wide cfDNA fragmentation patterns in cerebrospinal fluid informs medulloblastoma subtypes

Venkata Yellapantula, Ph.D., Assistant Professor of Clinical Pathology, Keck School of Medicine of USC

Tuesday, May 14, 2024

08:00 am - 10:30 am EST
Session 5: Clinical Implementation of Cell Free DNA Technologies

Session chairs: Aadel Chaudhuri M.D., Ph.D. and Trevor Pugh, Ph.D., FACMG

 

International R&D for ctDNA guided therapies for solid tumors: a clinical investigator's perspective

Bob Li, M.D., Associate Professor of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medicine

 

Multi-analyte and multi-modal cell-free DNA analysis to detect cancer early

Aadel Chaudhuri, M.D., Ph.D., Assistant Professor of Radiation Oncology, Mayo Clinic

 

Hereditary cancer surveillance using multi-modal cell-free DNA sequencing

Trevor Pugh, Ph.D., FACMG, Senior Investigator, Ontario Institute for Cancer Research

 

Applying genomics to address health disparities in organ transplants

Hannah Valantine, M.D., Professor of Medicine, Stanford University

 

The NIH IDENTIFY study: Do unusual prenatal cfDNA sequencing results act as a liquid biopsy to detect maternal malignancies?

Diana Bianchi, M.D., Director, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH

 

 

10:30 am - 11:00 am EST

Coffee/tea break with light refreshments

Supported by Foundation Medicine, Inc.

11:00 am - 12:30 pm EST
Session 6: Liquid Biopsies: Beyond Genomics

Session chairs: Julia Burner, Ph.D. and Simon Heeke, Ph.D.

               

Epigenomic features in ctDNA from metastatic prostate cancer

Alexander Wyatt, Ph.D., Associate Professor in Urologic Sciences, University of British Columbia

 

Cystatin SN as an innovative salivary biomarker for periodontitis: a controlled pilot study

Francesco Franco, Ph.D. candidate in Experimental Medicine and Therapy, University of Turin

 

Dissecting the circulating proteome in NF1-associated peripheral nerve sheath tumors
Taylor Sundby, M.D., Assistant Research Physician, National Cancer Institute

 

Everything everywhere all at once: evolving ocular liquid biopsies
Liya Xu, Ph.D., Assistant Professor, Keck School of Medicine of USC

 

Enrichment of tumor-associated fragmentomic features detected in cell-free DNA with sonobiopsy in glioma patients

Pradeep Chuahan, Ph.D., Staff Scientist, Washington University School of Medicine in St. Louis

 

12:30 pm - 02:00 pm EST
Lunch and Poster Session

Poster session

12:30–2:00 pm 

 

Boxed lunch

Supported by AstraZeneca

 

Lunch topical issues roundtable discussions (advance sign-up required)

12:45-1:30pm

 

Bob Li, M.D. (Memorial Sloan Kettering): International multi-stakeholder collaboration on liquid biopsy
David Fabrizio (Foundation Medicine) and Diana Vega, Ph.D. (AstraZeneca): At the edge of innovation: leveraging insights of molecular residual disease to propel precision medicine

Esta Sterneck, Ph.D. (NCI) and Catherine Alix-Panabières, Ph.D. (University of Montpellier): Circulating tumor cells interest lunch group (no sign-up required)

 

02:00 pm - 03:00 pm EST
Session 7: Late Breaking Topics in Liquid Biopsy Research

Session chairs: David Takeda, M.D., Ph.D. and Kevin Gerrish, Ph.D.

 

Circulating, cell-free methylated DNA reveals cellular sources of graft injury after liver transplant

Megan McNamara, M.D./Ph.D. candidate, Georgetown Univeristy School of Medicine

 

COVID-19 proteins in extracellular vesicles are linked to immune, coagulation, and cardiovascular complications and poor outcomes in severe disease patients

Diego de Miguel Perez, Ph.D., Postdoctoral Fellow, Icahn School of Medicine at Mount Sinai

 

Cell-free DNA methylation signatures: bridging the gap in ALS biomarker discovery

Yulin Jin, Ph.D., Postdoctoral Fellow, Emory University School of Medicine

 

Combined donor- and recipient- cell-free DNA signatures provide accurate detection of cardiac allograft rejection

Temesgen Andargie, Ph.D., Postdoctoral Fellow, National Heart, Lung, and Blood Institute, NIH

 

Detecting small cell transformation in patients with EGFR mutant lung adenocarcinoma through epigenomic cfDNA profiling

Jacob Berchuck, M.D., Assistant Professor of Medicine, Harvard Medical School

03:00 pm - 04:00 pm EST
Session 8: Panel Discussion: The Future of Liquid Biopsies

Session moderators: Dennis Lo, Ph.D. and Sean Agbor-Enoh, M.D., Ph.D.

 

Participants: Alexander Wyatt, Ph.D., Diana Bianchi, M.D., Ignatia Barbara Van den Veyver, M.D. and Philip Castle, Ph.D., M.P.H.

 

Audience Q&A at the end of the session